ID   JELL3_APIME             Reviewed;           9 AA.
AC   P84759;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Jellein-3;
DE   AltName: Full=Jelleine-III;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT LEU-9.
RX   PubMed=15203237; DOI=10.1016/j.peptides.2004.03.016;
RA   Fontana R., Mendes M.A., de Souza B.M., Konno K., Cesar L.M., Malaspina O.,
RA   Palma M.S.;
RT   "Jelleines: a family of antimicrobial peptides from the royal jelly of
RT   honeybees (Apis mellifera).";
RL   Peptides 25:919-928(2004).
CC   -!- FUNCTION: Has antibacterial activity against the Gram-positive bacteria
CC       S.aureus ATCC 6535 and S.saprophyticus, and the Gram-negative bacteria
CC       E.coli CCT1371, E.cloacae ATCC 23355, K.pneumoniae ATCC 13883 and
CC       P.aeruginosa ATCC 27853, and antifungal activity against C.albicans.
CC       Lacks cytolytic activity and do not induce rat peritoneal mast cell
CC       degranulation. {ECO:0000269|PubMed:15203237}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15203237}.
CC   -!- TISSUE SPECIFICITY: Found in the hypopharyngeal glands of the worker
CC       honeybee. {ECO:0000269|PubMed:15203237}.
CC   -!- MASS SPECTROMETRY: Mass=1082.32; Mass_error=0.19; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15203237};
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DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..9
FT                   /note="Jellein-3"
FT                   /id="PRO_0000223883"
FT   MOD_RES         9
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:15203237"
SQ   SEQUENCE   9 AA;  1083 MW;  3230E045B05339D7 CRC64;
     EPFKISIHL