JERKL_HUMAN
ID JERKL_HUMAN Reviewed; 524 AA.
AC Q9Y4A0; A8K3G4; B2RAJ3; Q32MC2;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Jerky protein homolog-like;
DE AltName: Full=Human homolog of mouse jerky gene protein;
DE Short=HHMJG;
GN Name=JRKL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 17-524.
RX PubMed=9240447; DOI=10.1006/bbrc.1997.6935;
RA Zeng Z., Kyaw H., Gakenheimer K.R., Augustus M., Fan P., Zhang X., Su K.,
RA Carter K.C., Li Y.;
RT "Cloning, mapping, and tissue distribution of a human homologue of the
RT mouse jerky gene product.";
RL Biochem. Biophys. Res. Commun. 236:389-395(1997).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC ECO:0000255|PROSITE-ProRule:PRU00583}.
CC -!- TISSUE SPECIFICITY: Abundantly expressed in the majority of tissues
CC examined, including brain and skeletal muscle.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB65833.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK290579; BAF83268.1; -; mRNA.
DR EMBL; AK314216; BAG36890.1; -; mRNA.
DR EMBL; AP003781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW66986.1; -; Genomic_DNA.
DR EMBL; BC109202; AAI09203.1; -; mRNA.
DR EMBL; AF004715; AAB65833.1; ALT_INIT; mRNA.
DR CCDS; CCDS8308.1; -.
DR PIR; JC5594; JC5594.
DR RefSeq; NP_001248762.1; NM_001261833.1.
DR RefSeq; NP_003763.2; NM_003772.3.
DR AlphaFoldDB; Q9Y4A0; -.
DR SMR; Q9Y4A0; -.
DR BioGRID; 114237; 7.
DR IntAct; Q9Y4A0; 7.
DR STRING; 9606.ENSP00000333350; -.
DR iPTMnet; Q9Y4A0; -.
DR PhosphoSitePlus; Q9Y4A0; -.
DR BioMuta; JRKL; -.
DR DMDM; 254763306; -.
DR EPD; Q9Y4A0; -.
DR jPOST; Q9Y4A0; -.
DR MassIVE; Q9Y4A0; -.
DR MaxQB; Q9Y4A0; -.
DR PaxDb; Q9Y4A0; -.
DR PeptideAtlas; Q9Y4A0; -.
DR PRIDE; Q9Y4A0; -.
DR ProteomicsDB; 86140; -.
DR Antibodypedia; 31694; 114 antibodies from 19 providers.
DR DNASU; 8690; -.
DR Ensembl; ENST00000332349.5; ENSP00000333350.4; ENSG00000183340.7.
DR GeneID; 8690; -.
DR KEGG; hsa:8690; -.
DR MANE-Select; ENST00000332349.5; ENSP00000333350.4; NM_001261833.2; NP_001248762.1.
DR UCSC; uc009ywu.5; human.
DR CTD; 8690; -.
DR GeneCards; JRKL; -.
DR HGNC; HGNC:6200; JRKL.
DR HPA; ENSG00000183340; Low tissue specificity.
DR MIM; 603211; gene.
DR neXtProt; NX_Q9Y4A0; -.
DR OpenTargets; ENSG00000183340; -.
DR PharmGKB; PA30002; -.
DR VEuPathDB; HostDB:ENSG00000183340; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000161513; -.
DR HOGENOM; CLU_018294_1_1_1; -.
DR InParanoid; Q9Y4A0; -.
DR OMA; ERVTVMC; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; Q9Y4A0; -.
DR TreeFam; TF101131; -.
DR PathwayCommons; Q9Y4A0; -.
DR SignaLink; Q9Y4A0; -.
DR BioGRID-ORCS; 8690; 12 hits in 1086 CRISPR screens.
DR GenomeRNAi; 8690; -.
DR Pharos; Q9Y4A0; Tdark.
DR PRO; PR:Q9Y4A0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9Y4A0; protein.
DR Bgee; ENSG00000183340; Expressed in buccal mucosa cell and 197 other tissues.
DR Genevisible; Q9Y4A0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; TAS:ProtInc.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..524
FT /note="Jerky protein homolog-like"
FT /id="PRO_0000126130"
FT DOMAIN 1..52
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 67..139
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 168..385
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 28..48
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 100..132
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT CONFLICT 59
FT /note="S -> F (in Ref. 1; BAF83268)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="F -> S (in Ref. 1; BAG36890)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="T -> I (in Ref. 1; BAG36890)"
FT /evidence="ECO:0000305"
FT CONFLICT 433
FT /note="E -> K (in Ref. 1; BAG36890)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 524 AA; 59912 MW; 81FEC7468DCBBF47 CRC64;
MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE KIITYASSSD
STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP ICAKRAEFFF YALGMDGDFN
PSAGWLTRFK QRHSIREINI RNERLNGDET AVEDFCNNFR DFIERENLQP EQIYNADETG
LFWKCLPSRI SVIKGKCTVP GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST
DTLNLPVSYF SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE
NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG NDLKSFWKKL
TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF DVEDISVATV AAILQHTKGL
ENVTTENLEK WLEVDSTEPG YEVLTDSEII RRAQGQADES SENEEEEIEL IPEKHINHAA
ALQWTENLLD YLEQQGDMIL PDRLVIRKLR ATIRNKQKMT KSSQ
