JERKL_MOUSE
ID JERKL_MOUSE Reviewed; 523 AA.
AC B2RRL2; Q3V2Y6;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Jerky protein homolog-like;
GN Name=Jrkl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 264-523.
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC ECO:0000255|PROSITE-ProRule:PRU00583}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE43369.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE43369.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CH466522; EDL24967.1; -; Genomic_DNA.
DR EMBL; BC138472; AAI38473.1; -; mRNA.
DR EMBL; BC138475; AAI38476.1; -; mRNA.
DR EMBL; AK079877; BAE43369.1; ALT_SEQ; mRNA.
DR CCDS; CCDS57650.1; -.
DR RefSeq; NP_001028353.1; NM_001033181.1.
DR AlphaFoldDB; B2RRL2; -.
DR SMR; B2RRL2; -.
DR STRING; 10090.ENSMUSP00000128798; -.
DR iPTMnet; B2RRL2; -.
DR PhosphoSitePlus; B2RRL2; -.
DR EPD; B2RRL2; -.
DR jPOST; B2RRL2; -.
DR PaxDb; B2RRL2; -.
DR PeptideAtlas; B2RRL2; -.
DR PRIDE; B2RRL2; -.
DR ProteomicsDB; 301697; -.
DR Antibodypedia; 31694; 114 antibodies from 19 providers.
DR Ensembl; ENSMUST00000110582; ENSMUSP00000128798; ENSMUSG00000079083.
DR GeneID; 77532; -.
DR KEGG; mmu:77532; -.
DR UCSC; uc012hdj.1; mouse.
DR CTD; 8690; -.
DR MGI; MGI:1924782; Jrkl.
DR VEuPathDB; HostDB:ENSMUSG00000079083; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000161513; -.
DR HOGENOM; CLU_018294_1_1_1; -.
DR InParanoid; B2RRL2; -.
DR OMA; ERVTVMC; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; B2RRL2; -.
DR TreeFam; TF101131; -.
DR BioGRID-ORCS; 77532; 2 hits in 72 CRISPR screens.
DR PRO; PR:B2RRL2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; B2RRL2; protein.
DR Bgee; ENSMUSG00000079083; Expressed in granulocyte and 59 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..523
FT /note="Jerky protein homolog-like"
FT /id="PRO_0000379975"
FT DOMAIN 1..52
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 67..139
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 168..385
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 28..48
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 100..132
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT CONFLICT 506
FT /note="R -> T (in Ref. 3; BAE43369)"
FT /evidence="ECO:0000305"
FT CONFLICT 515
FT /note="K -> R (in Ref. 3; BAE43369)"
FT /evidence="ECO:0000305"
FT CONFLICT 520
FT /note="N -> T (in Ref. 3; BAE43369)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 523 AA; 59710 MW; CAF113771D5162B0 CRC64;
MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE KIITYASSSD
STSLLAKRKS MKPSMYEELD KAMLEWFNQQ RAKGNPISGP ICAKRAEFFF YALGMDGDFN
PSAGWLTRFK QRHSIREINI RNERLNGDET AVEDFCNNFR DFIEQENLQP EQIYNADETG
LFWKCLPSRT TVIKGKCTVP GHNLGEERIT VMCCTNATGL HKLKLCVVGK ARKPRSFKST
DTLNLPVSYF SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE
NVLRSDDGQI FAKYLPPNVA SLIQPLGQGV IAAMKRNYRA GLLHNNLEEG NDLKSFWKKL
TLLDALYEIA MAWNLVKPVT ISRAWKQILP AIEEKEGLDF DEDISGATVA TILQHTKGLE
NVTPENLEKW LEIDSTEPGY EVLTDSEIIR RAQGQTDESS ENDEERIELI PEKHINHTTA
LQWTENLLDY LEQQGDMILP DRLVIRKLRA TIRNKQKMTN PGQ
