ID   JERKY_MOUSE             Reviewed;         557 AA.
AC   Q60976;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=Jerky protein {ECO:0000303|PubMed:7550318};
GN   Name=Jrk {ECO:0000312|MGI:MGI:106214};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL / 6J-TGN[LACTAG]40-5TOT; TISSUE=Brain;
RX   PubMed=7550318; DOI=10.1038/ng0995-71;
RA   Toth M., Grimsby J., Buzsaki G., Donovan G.P.;
RT   "Epileptic seizures caused by inactivation of a novel gene, jerky, related
RT   to centromere binding protein-B in transgenic mice.";
RL   Nat. Genet. 11:71-75(1995).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RA   Toth M.P.;
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC       ECO:0000255|PROSITE-ProRule:PRU00583}.
CC   -!- TISSUE SPECIFICITY: Brain; highest in the temporal and brainstem
CC       regions.
CC   -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC       family. {ECO:0000305}.
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DR   EMBL; U35730; AAC39941.2; -; mRNA.
DR   CCDS; CCDS27524.1; -.
DR   RefSeq; NP_032441.4; NM_008415.6.
DR   AlphaFoldDB; Q60976; -.
DR   SMR; Q60976; -.
DR   STRING; 10090.ENSMUSP00000051842; -.
DR   iPTMnet; Q60976; -.
DR   PhosphoSitePlus; Q60976; -.
DR   PaxDb; Q60976; -.
DR   PRIDE; Q60976; -.
DR   ProteomicsDB; 269362; -.
DR   Antibodypedia; 27777; 24 antibodies from 11 providers.
DR   DNASU; 16469; -.
DR   Ensembl; ENSMUST00000050234; ENSMUSP00000051842; ENSMUSG00000046380.
DR   GeneID; 16469; -.
DR   KEGG; mmu:16469; -.
DR   UCSC; uc007wfp.2; mouse.
DR   CTD; 8629; -.
DR   MGI; MGI:106214; Jrk.
DR   VEuPathDB; HostDB:ENSMUSG00000046380; -.
DR   eggNOG; KOG3105; Eukaryota.
DR   GeneTree; ENSGT00940000162277; -.
DR   HOGENOM; CLU_018294_1_1_1; -.
DR   InParanoid; Q60976; -.
DR   OMA; RDFMRHF; -.
DR   OrthoDB; 1343623at2759; -.
DR   PhylomeDB; Q60976; -.
DR   TreeFam; TF101131; -.
DR   BioGRID-ORCS; 16469; 8 hits in 72 CRISPR screens.
DR   ChiTaRS; Jrk; mouse.
DR   PRO; PR:Q60976; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q60976; protein.
DR   Bgee; ENSMUSG00000046380; Expressed in ureteric bud trunk and 174 other tissues.
DR   ExpressionAtlas; Q60976; baseline and differential.
DR   Genevisible; Q60976; MM.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IDA:MGI.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:MGI.
DR   InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR   InterPro; IPR007889; HTH_Psq.
DR   Pfam; PF04218; CENP-B_N; 1.
DR   Pfam; PF03184; DDE_1; 1.
DR   Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR   SMART; SM00674; CENPB; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51253; HTH_CENPB; 1.
DR   PROSITE; PS50960; HTH_PSQ; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..557
FT                   /note="Jerky protein"
FT                   /id="PRO_0000126129"
FT   DOMAIN          11..62
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DOMAIN          77..149
FT                   /note="HTH CENPB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT   DOMAIN          213..382
FT                   /note="DDE-1"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        38..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DNA_BIND        110..142
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
SQ   SEQUENCE   557 AA;  62478 MW;  2AFEA1752C2FEA6B CRC64;
     MASKQAAAKG KGEKRKRVVL TLKEKIDICT RLERGESRKA LMQEYNVGMS TLYDIKAHKA
     QLLRFFASSD SRQALEQRRT LHTPKLEHLD RVLYEWFLVK RAEGIPVSGP MLIEKAKDFY
     KQMRLTEPCV FSGGWLWRFK ARHGIKKLDA SSEKQAADHQ AAEQFCGFFR SLAAEHGLSP
     EQVYSADETG LVWRCLPNSA PDDGTVPHFK QGKDRLTVLM CANATGSHRI KPLAIGKGGG
     PRAFRGIQHL PIAYKAQGNA WVDKEIFSDW FHHIFVPSVR EHFRTIGLPE DSKAILLLDH
     SRAHSQESEL VSENVFTIFL PSSVTSLLQP TEQGIRRAFM RLFINPPVAF QGFPTRHNIN
     DAIVNVARAW NAVPSQVFQR AWRKLWPTVT FTEGSSSEEE AECCAIKPHK TFAHILGLVK
     EGPTCSGSRL QDSRVEERVV AGRDIDEAPA IVAPSQATRC TKKSEKDTGE TEEAAWEQAA
     TSFEALVRFA ERQPCFSVQE MGQLQALHTV FRRQQQLRQP RVALRAVIKL EALQEHPGVC
     VATTHPTLPC SSTAGDN