ID   JETD_BACCQ              Reviewed;         409 AA.
AC   B9IS86;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Wadjet protein JetD {ECO:0000303|PubMed:29371424};
GN   Name=jetD {ECO:0000303|PubMed:29371424};
GN   OrderedLocusNames=BCQ_1018 {ECO:0000312|EMBL:ACM11448.1};
OS   Bacillus cereus (strain Q1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=361100;
RN   [1] {ECO:0000312|EMBL:ACM11448.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Q1;
RX   PubMed=19060151; DOI=10.1128/jb.01629-08;
RA   Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X.,
RA   Xue Y., Zhu Y., Jin Q.;
RT   "Complete genome sequence of the extremophilic Bacillus cereus strain Q1
RT   with industrial applications.";
RL   J. Bacteriol. 191:1120-1121(2009).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLU-274.
RC   STRAIN=Q1;
RX   PubMed=29371424; DOI=10.1126/science.aar4120;
RA   Doron S., Melamed S., Ofir G., Leavitt A., Lopatina A., Keren M.,
RA   Amitai G., Sorek R.;
RT   "Systematic discovery of antiphage defense systems in the microbial
RT   pangenome.";
RL   Science 359:0-0(2018).
CC   -!- FUNCTION: Component of antiplasmid transformation system Wadjet type I,
CC       composed of JetA, JetB, JetC and JetD. Expression of Wadjet type I in
CC       B.subtilis (strain BEST7003) reduces the transformation efficiency of
CC       plasmid pHCMC05. {ECO:0000269|PubMed:29371424}.
CC   -!- DISRUPTION PHENOTYPE: When this gene is missing the Wadjet system does
CC       not confer plasmid-transformation resistance in B.subtilis.
CC       {ECO:0000269|PubMed:29371424}.
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DR   EMBL; CP000227; ACM11448.1; -; Genomic_DNA.
DR   RefSeq; WP_000384974.1; NC_011969.1.
DR   EnsemblBacteria; ACM11448; ACM11448; BCQ_1018.
DR   KEGG; bcq:BCQ_1018; -.
DR   HOGENOM; CLU_054915_2_0_9; -.
DR   OMA; YHWGDID; -.
DR   Proteomes; UP000000441; Chromosome.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR024534; DUF2220.
DR   InterPro; IPR036078; Spo11/TopoVI_A_sf.
DR   Pfam; PF09983; DUF2220; 1.
DR   SUPFAM; SSF56726; SSF56726; 1.
PE   1: Evidence at protein level;
FT   CHAIN           1..409
FT                   /note="Wadjet protein JetD"
FT                   /id="PRO_0000456348"
FT   MUTAGEN         274
FT                   /note="E->A: No longer protects against plasmid
FT                   transformation."
FT                   /evidence="ECO:0000269|PubMed:29371424"
SQ   SEQUENCE   409 AA;  48720 MW;  8B553F32D3610A98 CRC64;
     MDYKSKILSV LLNKYENSKT AHTGERSAQR PQFSFRQKHE LSKAYNDEMD YTNRLEINTA
     LKDLIRKKII EVKWEKWEEN RIAEKVYLQY DFIPQAYREA GIEPKIEKMN RILKVLEPLA
     VHSWEWVRQW YKEVQQSFQN NKTARINLND VKGYELLVKA LSRLEGLEDS IPKRTFSQLV
     FGDTKLFETT IQNRLLIIYK RYGDIEYESD KEYLESIGIL ENIQPVYIKG NVDIRVRGEK
     IALGSFPGGF GLMDETIKEL EIQYVHDESI MLIENMTTYY EQIKKNNNIL FIYTGGFPKK
     NVQQLLKKLN IYLENHPVPV YHYGDLDYGG IQIFEYIKRS FFSGLEPYMM DVATYRQFVK
     YGMEFGEGYE EKLLKMLENE QYSLWHELIK EMLKEKKRVE QEVIVRNVI