JGN1A_DANRE
ID JGN1A_DANRE Reviewed; 183 AA.
AC Q5XJX0; B0S5W1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein jagunal homolog 1-A {ECO:0000305};
GN Name=jagn1a; ORFNames=si:ch211-283e2.4, zgc:101070;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION.
RX PubMed=17389229; DOI=10.1083/jcb.200701048;
RA Lee S., Cooley L.;
RT "Jagunal is required for reorganizing the endoplasmic reticulum during
RT Drosophila oogenesis.";
RL J. Cell Biol. 176:941-952(2007).
CC -!- FUNCTION: Endoplasmic reticulum transmembrane protein involved in
CC vesicle-mediated transport, which is required for neutrophil function.
CC {ECO:0000250|UniProtKB:Q5XKN4, ECO:0000250|UniProtKB:Q8N5M9}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8N5M9}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the jagunal family. {ECO:0000305}.
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DR EMBL; BX322575; CAQ14994.1; -; Genomic_DNA.
DR EMBL; BC083169; AAH83169.1; -; mRNA.
DR RefSeq; NP_001005774.1; NM_001005774.2.
DR AlphaFoldDB; Q5XJX0; -.
DR SMR; Q5XJX0; -.
DR STRING; 7955.ENSDARP00000060173; -.
DR PaxDb; Q5XJX0; -.
DR Ensembl; ENSDART00000060174; ENSDARP00000060173; ENSDARG00000041071.
DR Ensembl; ENSDART00000181031; ENSDARP00000155233; ENSDARG00000109427.
DR GeneID; 449830; -.
DR KEGG; dre:449830; -.
DR CTD; 449830; -.
DR ZFIN; ZDB-GENE-041010-80; jagn1a.
DR eggNOG; KOG4054; Eukaryota.
DR GeneTree; ENSGT00390000005596; -.
DR HOGENOM; CLU_121621_0_0_1; -.
DR InParanoid; Q5XJX0; -.
DR OMA; VWRGYPY; -.
DR OrthoDB; 1452436at2759; -.
DR PhylomeDB; Q5XJX0; -.
DR TreeFam; TF313137; -.
DR PRO; PR:Q5XJX0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000041071; Expressed in brain and 10 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; ISS:UniProtKB.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR GO; GO:0038158; P:granulocyte colony-stimulating factor signaling pathway; ISS:UniProtKB.
DR GO; GO:0030223; P:neutrophil differentiation; ISS:UniProtKB.
DR GO; GO:0002446; P:neutrophil mediated immunity; ISS:UniProtKB.
DR GO; GO:1990266; P:neutrophil migration; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR InterPro; IPR009787; Jagunal.
DR PANTHER; PTHR20955; PTHR20955; 1.
DR Pfam; PF07086; Jagunal; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Immunity; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..183
FT /note="Protein jagunal homolog 1-A"
FT /id="PRO_0000313612"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..66
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..137
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..183
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 183 AA; 20578 MW; 29D256407ED44DBB CRC64;
MASRAGPRAA GTDGGDFKHR EKVASHYQMS ASSKSEIKKL TVVHFLIWIL VAAQVAVSHL
NLVSHDLVAM PYQWEYPYLL SLVPSFIGAL AMPKNNISYL VISMISAGLF SVAPLIFGAM
EMFPLAQQLY RHGKAYRFIF GFSAVSVMYL LMVIAIQVHA WQIYYSKKLL DAWFNSTLEK
KKK
