ID   JHBP_MANSE              Reviewed;         229 AA.
AC   P15500;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Juvenile hormone-binding protein;
DE   Flags: Precursor; Fragment;
GN   Name=JHBP;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2246263; DOI=10.1016/s0021-9258(17)45443-3;
RA   Lerro K.A., Prestwich G.D.;
RT   "Cloning and sequencing of a cDNA for the hemolymph juvenile hormone
RT   binding protein of larval Manduca sexta.";
RL   J. Biol. Chem. 265:19800-19806(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 4-38.
RX   PubMed=3342877; DOI=10.1016/0014-5793(88)80582-9;
RA   Kulcsar P., Prestwich G.D.;
RT   "Detection and microsequencing of juvenile hormone-binding proteins of an
RT   insect by the use of an iodinated juvenile hormone analog.";
RL   FEBS Lett. 228:49-52(1988).
CC   -!- FUNCTION: Prevents juvenile hormone from being hydrolyzed by general
CC       esterases by combining with it specifically.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; M59436; AAA29317.1; -; mRNA.
DR   PIR; A40668; A40668.
DR   AlphaFoldDB; P15500; -.
DR   SMR; P15500; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.15.10.30; -; 1.
DR   InterPro; IPR010562; Haemolymph_juvenile_hormone-bd.
DR   InterPro; IPR038606; To_sf.
DR   Pfam; PF06585; JHBP; 1.
DR   SMART; SM00700; JHBP; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          <1..3
FT                   /evidence="ECO:0000269|PubMed:3342877"
FT   CHAIN           4..229
FT                   /note="Juvenile hormone-binding protein"
FT                   /id="PRO_0000021533"
FT   VARIANT         22
FT                   /note="R -> T"
FT   VARIANT         29
FT                   /note="E -> D"
FT   VARIANT         37..38
FT                   /note="EY -> NI"
FT   NON_TER         1
SQ   SEQUENCE   229 AA;  25411 MW;  883B0CF2C45CB4D4 CRC64;
     VLSDQGALFE PCSTQDIACL SRATQQFLEK ACRGVPEYDI RPIDPLIISS LDVAAYDDIG
     LIFHFKNLNI TGLKNQKISD FRMDTTRKSV LLKTQADLNV VADVVIELSK QSKSFAGVMN
     IQASIIGGAK YSYDLQDDSK GVKHFEVGQE TISCESIGEP AVNLNPELAD ALLKDPDTTH
     YRKDYEAHRV SIRQRSLCKI VELCYVDVVH NIRAVAKILP STAFFTDVN