ID   JHEA_TRINI              Reviewed;         109 AA.
AC   P30809;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Juvenile hormone esterase, isoform A;
DE            Short=JH esterase;
DE            Short=JHE-A;
DE            EC=3.1.1.59;
DE   Flags: Fragments;
OS   Trichoplusia ni (Cabbage looper).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Plusiinae; Trichoplusia.
OX   NCBI_TaxID=7111;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7679289; DOI=10.1016/0167-4838(93)90219-h;
RA   Jones G., Manczak M., Wozniak M., Ko'Rrati R.;
RT   "Characterization of two major isoforms of juvenile hormone esterase from
RT   Trichoplusia ni (Lepidoptera).";
RL   Biochim. Biophys. Acta 1161:235-243(1993).
CC   -!- FUNCTION: JH esterase plays a crucial role in the decrease of JH
CC       activity in lepidopteran insects, by hydrolyzing the methyl ester of
CC       JH. It is also involved in the transport of JH.
CC       {ECO:0000250|UniProtKB:P19985}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + juvenile hormone I = H(+) + juvenile hormone I
CC         carboxylate + methanol; Xref=Rhea:RHEA:46916, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:83641,
CC         ChEBI:CHEBI:87109; EC=3.1.1.59;
CC         Evidence={ECO:0000250|UniProtKB:P19985};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + juvenile hormone III = H(+) + juvenile hormone III
CC         carboxylate + methanol; Xref=Rhea:RHEA:46912, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:27493,
CC         ChEBI:CHEBI:83274; EC=3.1.1.59;
CC         Evidence={ECO:0000250|UniProtKB:P19985};
CC   -!- TISSUE SPECIFICITY: Fat body, the site of their biosynthesis, and the
CC       hemolymph where it is secreted.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000305}.
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DR   PIR; S29655; S29655.
DR   AlphaFoldDB; P30809; -.
DR   BindingDB; P30809; -.
DR   ChEMBL; CHEMBL2366569; -.
DR   Proteomes; UP000322000; Genome assembly.
DR   GO; GO:0004453; F:juvenile-hormone esterase activity; IEA:UniProtKB-EC.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Reference proteome; Serine esterase.
FT   CHAIN           1..>109
FT                   /note="Juvenile hormone esterase, isoform A"
FT                   /id="PRO_0000070292"
FT   NON_CONS        30..31
FT                   /evidence="ECO:0000305"
FT   NON_CONS        43..44
FT                   /evidence="ECO:0000305"
FT   NON_CONS        48..49
FT                   /evidence="ECO:0000305"
FT   NON_CONS        57..58
FT                   /evidence="ECO:0000305"
FT   NON_CONS        80..81
FT                   /evidence="ECO:0000305"
FT   NON_CONS        93..94
FT                   /evidence="ECO:0000305"
FT   NON_TER         109
SQ   SEQUENCE   109 AA;  11814 MW;  1CD4B020163BC9B8 CRC64;
     LPSLSADAEA PSPLSLKADA PLAHIDSGLL GVPYAKQPIG ELRVTTLRLI ELPPEKLVVG
     APVYLYQFSY ESPSSAIKQE VVGHIEDLTY VFKGSQYQDI ESPTAYQSK