JHY_MOUSE
ID JHY_MOUSE Reviewed; 770 AA.
AC E9Q793; E0CX29; Q9CUE4;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Jhy protein {ECO:0000303|PubMed:23906841};
DE AltName: Full=Juvenile hydrocephalus protein {ECO:0000303|PubMed:23906841};
GN Name=Jhy {ECO:0000303|PubMed:23906841, ECO:0000312|MGI:MGI:1918239};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-770.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=23906841; DOI=10.1016/j.ydbio.2013.07.003;
RA Appelbe O.K., Bollman B., Attarwala A., Triebes L.A., Muniz-Talavera H.,
RA Curry D.J., Schmidt J.V.;
RT "Disruption of the mouse Jhy gene causes abnormal ciliary microtubule
RT patterning and juvenile hydrocephalus.";
RL Dev. Biol. 382:172-185(2013).
CC -!- FUNCTION: Required for the normal development of cilia in brain
CC ependymal cells lining the ventricular surfaces.
CC {ECO:0000269|PubMed:23906841}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, specifically in
CC hypothalamus, pineal gland, and ependymal cells of the aqueduct of
CC Sylvius, as well as in the choroid plexus of the third ventricle.
CC Expressed in the ependymal cells lining the lateral ventricles (at
CC protein level). {ECO:0000269|PubMed:23906841}.
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DR EMBL; AC159820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK016487; BAB30266.1; -; mRNA.
DR CCDS; CCDS40592.1; -.
DR RefSeq; NP_001074590.1; NM_001081121.1.
DR RefSeq; XP_006510662.1; XM_006510599.3.
DR RefSeq; XP_006510663.1; XM_006510600.3.
DR AlphaFoldDB; E9Q793; -.
DR STRING; 10090.ENSMUSP00000034521; -.
DR iPTMnet; E9Q793; -.
DR PhosphoSitePlus; E9Q793; -.
DR MaxQB; E9Q793; -.
DR PaxDb; E9Q793; -.
DR PRIDE; E9Q793; -.
DR ProteomicsDB; 269027; -.
DR Antibodypedia; 49546; 16 antibodies from 6 providers.
DR Ensembl; ENSMUST00000034521; ENSMUSP00000034521; ENSMUSG00000032023.
DR GeneID; 70989; -.
DR KEGG; mmu:70989; -.
DR UCSC; uc009pac.1; mouse.
DR CTD; 79864; -.
DR MGI; MGI:1918239; Jhy.
DR VEuPathDB; HostDB:ENSMUSG00000032023; -.
DR eggNOG; ENOG502S6KC; Eukaryota.
DR GeneTree; ENSGT00390000002823; -.
DR HOGENOM; CLU_407472_0_0_1; -.
DR InParanoid; E9Q793; -.
DR OMA; IHQKEYA; -.
DR OrthoDB; 1114555at2759; -.
DR TreeFam; TF335473; -.
DR BioGRID-ORCS; 70989; 6 hits in 75 CRISPR screens.
DR ChiTaRS; Jhy; mouse.
DR PRO; PR:E9Q793; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; E9Q793; protein.
DR Bgee; ENSMUSG00000032023; Expressed in spermatid and 26 other tissues.
DR ExpressionAtlas; E9Q793; baseline and differential.
DR Genevisible; E9Q793; MM.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0035082; P:axoneme assembly; IMP:MGI.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0030154; P:cell differentiation; IMP:MGI.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IMP:MGI.
DR GO; GO:0051649; P:establishment of localization in cell; IMP:MGI.
DR GO; GO:0044458; P:motile cilium assembly; IMP:MGI.
DR GO; GO:0090175; P:regulation of establishment of planar polarity; IMP:MGI.
DR InterPro; IPR027968; JHY.
DR PANTHER; PTHR14726; PTHR14726; 1.
DR Pfam; PF15261; JHY; 1.
PE 1: Evidence at protein level;
KW Cilium biogenesis/degradation; Reference proteome.
FT CHAIN 1..770
FT /note="Jhy protein"
FT /id="PRO_0000442261"
FT REGION 1..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..638
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 87417 MW; 2477A2667C344485 CRC64;
MNKYKPVPKL SSQSPVHHTN LRIPPSGRPF KKEDFLNLIS KDSLESDSES LPQEAKSWSD
IKDQIQDKDM EPDSLEEDSP SETEEAVNRK AAHNTNREDL SAHDAGVNHS QHQVEDKYSD
LRYDPNWKNK REEGQPLAGE ALPGSADSSS ENLPLAPLYP SREPSMGLSA GKGKEKKSPQ
SEASLLGSEF LSPKYERSTR QNGFFSELSD SDQEEKSSGL SQYLKSSSSH NDVFLPGSRG
PRRRKSKQYF VEKNKLTLGL PMPKTDSYLQ LHNKKRGETR LEQISYPVRD TDKMTVQNDK
EVENTFMDPE DKWHQRAKQL KNYQEHLSQY EDTKSGNVPR GQSSDAANGQ QPSRRTAKAR
VRKQRKHQKG LKSLGTKELV VSQNNQNNPF QQPQNQRQTA DASAKHELAA QTNASNPNLQ
DARTLTHNPK VTSDSFVSPK QALDRALYKN SISGLNANKR RGHRREEERI LYQPQPIYVF
SDTHLQDFNE LPHRHESPSQ RAPQSDHHMN THRSTKTKKP AKQPQAETKY KNIEMLWKFH
SSSDMEPASA SPDSRLAQIM EQHQQALMQL AEVQPSEGSL ASIILPPILS RVESESQLNS
ERSHRHQVKM ARSNSEGYLL QLERGKRHRK RSSTKSSKLK GYQKRDVKLG GLGPDFASVR
DKMQMLMQQK EYAQQVKDYN MKALSILSKP QTSKTESKSA ISRKKALDYA KTIPKPKPPN
LPDQTAKKTK NSRHSEKEGG LPEISLLEIL QSRHEREKQA VAAFKVLHIV
