JING_AEDAE
ID JING_AEDAE Reviewed; 1605 AA.
AC Q17PR1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Zinc finger protein jing homolog;
GN ORFNames=AAEL000263;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: May functionally interact with Polycomb group (PcG) and
CC trithorax group (trxG) proteins to repress transcription.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AEBP2/jing C2H2-type zinc-finger family.
CC {ECO:0000305}.
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DR EMBL; CH477190; EAT48690.1; -; Genomic_DNA.
DR RefSeq; XP_001654760.1; XM_001654710.1.
DR AlphaFoldDB; Q17PR1; -.
DR SMR; Q17PR1; -.
DR STRING; 7159.AAEL000263-PA; -.
DR PRIDE; Q17PR1; -.
DR GeneID; 5573733; -.
DR KEGG; aag:5573733; -.
DR VEuPathDB; VectorBase:AAEL000263; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_260362_0_0_1; -.
DR InParanoid; Q17PR1; -.
DR OMA; NYTHVET; -.
DR OrthoDB; 404623at2759; -.
DR PhylomeDB; Q17PR1; -.
DR Proteomes; UP000008820; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
PE 3: Inferred from homology;
KW Chromatin regulator; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1605
FT /note="Zinc finger protein jing homolog"
FT /id="PRO_0000341594"
FT ZN_FING 1260..1285
FT /note="C2H2-type 1"
FT ZN_FING 1293..1320
FT /note="C2H2-type 2; degenerate"
FT ZN_FING 1326..1350
FT /note="C2H2-type 3"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..947
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1054
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1087
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1133..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1556..1605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1605 AA; 171290 MW; 41B22C1DAB7EEA55 CRC64;
MQHQSLSVRN SSGISGNRDE NFPSVRSSKV TVKTASISAK MAPHTQGSNL TIKQQYQPHQ
WPWNTSNNTN ATNSNNVQSN NNSSTATSNS STNSNNSPAV NTPTTQNQSQ PTTQQSNTAL
VAAAAAGTLS VTAVNKLKRL QPTTHSEAST NTRSNSTNTI ASGAKRIRTT NVEKVNKSVG
TNTTGLSGPP GLVAVGSSLT TSAANATTTK KLTQMAIVAA SNTSHHHQQI STAGTTTTTI
TKNAKNFTAS GNADLCNANK ITAGRATTLK TTTASSTTTA TAEAEAEITT TTELMTTTST
VLQQKSIIKT GPVKTSNAAS LEKYLNLLQQ QQATSITPAT TLKKVERKTA RIAPTVSLTR
KVSHSPQGGL GVGQPKKPVT IAPRTSDPKL SINYNQQMVA TTATSAISTG NQLIKQQDQQ
LVKSPQSTVL LTTIRIPQQQ QQHQQSTQTQ QQTSQNQSQP QQNQTQAQLQ AQQQFKQVVQ
QQLQLSSPPR TPTKLGSAVF QFHPQTTTVM PNLVQIPNLV PTQPVSSAAA KLNAPVVASS
TTSSPTTANL VMNNATHGLT ATRLNNGTTQ LYMNGAVIKL HQIQQQQQQA IGTAGQQAPT
PQQSLPMDSA TVSMGLNGLL TKSATLSTAA STISTNQPAH QAKAFTLHAQ KPTQLYQQAN
TSTATAYTPQ PFFMAPSGQI LLNTAALPTM LTSASLQQAL VQAAQANIPA LHPLQPSQPQ
STQLPNITAI IQQQQQQQQQ QQMLPNFHQL LANIPQAVLQ NLQSTTKLGQ TPQFVPIPSN
LFLNPQNPVY TSSPSSSSFT SPITISTSTL PSGSTTISQP LSPPPLVATV PTYTTTAKPI
MNTLNNQKII IASATSTTSS KPPPPIKPIS STEPPKLVPV QLNKPSISIT PVISNPPKLV
PPSAPVPKLV LSASVATKAT STTPIKDKPK PNLPMSEPPA LAPASCTPPL LTAPAPLPVA
SVPSPVLSPR AIDNKSPPAL NPLSLDCGSS NDSGIVANSS DTEDKSLTID LCSPGSPDST
PQKKDEESRQ ESTPSPVPSP SPLSEPPVIP AESEPEPEPE PELEPEPEME PEPETEPEPE
VEPEPEDEPH LEEPKIDESS EAVELPELED PQPSPPLPCE LPPPPTIETD LLDTLSLPPS
QKSPKSLLLE QIKLKLPDQP DDQPQESMSS DQDYSNQSPL DESSPTGSAE PSESQRSTTP
VDMSPPSIET DFLNTPQMTE SAKSPILSQP KTIRFPAQNG VHHNFGRKGF RRLSDGRLFG
VCYWSNCDAQ FDTSSKLLDH LQIQHVNTQT GPFACLWDGC KVHNKESCSR RWLERHVLSH
GGSKPHKCIV AGCGMRFGSQ LALEKHVNHH FNNTDNASAG KRSSDPPLPK VLRKTGKKLR
YRRQPWSARR FDFFDIGVME GLQHRLIMAG SVASARRGTV TFRGQAAGRR VTGFGAEVFV
KWYPREIISD DWIPEAEVTS TREISIYELN PDQRFELEAQ LKTNRKANAE LLFCLHELNL
KLQAEASSTS CSRSSFSSSS SSSSSSGCSS ASSSLISTPI PFNSRTEPKK LRKPPKQSYQ
PSSSGTTSSL SSVLSSSASS LLSNENSSSS SSSSSSSSSS SSSTS
