JING_DROME
ID JING_DROME Reviewed; 1486 AA.
AC Q7KHG2; A1Z6L6; Q95RE5; Q967Y2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Zinc finger protein jing;
DE AltName: Full=Zinc finger protein rhumba;
GN Name=jing; Synonyms=rhumba; ORFNames=CG9397, CG9403;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11152631; DOI=10.1242/dev.128.3.321;
RA Liu Y., Montell D.J.;
RT "Jing: a downstream target of slbo required for developmental control of
RT border cell migration.";
RL Development 128:321-330(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sonnenfeld M.J., Sedaghat Y., Miranda W.F., Crews S.T.;
RT "The Drosophila rhumba gene encodes a C2H2 zinc finger protein essential
RT for patterning of embryonic CNS axons and tracheal tubules.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=12015288; DOI=10.1242/dev.129.11.2591;
RA Sedaghat Y., Miranda W.F., Sonnenfeld M.J.;
RT "The jing Zn-finger transcription factor is a mediator of cellular
RT differentiation in the Drosophila CNS midline and trachea.";
RL Development 129:2591-2606(2002).
RN [8]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=12111212; DOI=10.1007/s00427-002-0240-5;
RA Sedaghat Y., Sonnenfeld M.J.;
RT "The jing gene is required for embryonic brain development in Drosophila.";
RL Dev. Genes Evol. 212:277-287(2002).
RN [9]
RP ERRATUM OF PUBMED:12111212.
RA Sedaghat Y., Sonnenfeld M.J.;
RL Dev. Genes Evol. 213:106-106(2002).
RN [10]
RP FUNCTION.
RX PubMed=15511644; DOI=10.1016/j.mod.2004.07.006;
RA Sonnenfeld M.J., Barazesh N., Sedaghat Y., Fan C.;
RT "The jing and ras1 pathways are functionally related during CNS midline and
RT tracheal development.";
RL Mech. Dev. 121:1531-1547(2004).
RN [11]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16510782; DOI=10.1534/genetics.106.056341;
RA Culi J., Aroca P., Modolell J., Mann R.S.;
RT "jing is required for wing development and to establish the proximo-distal
RT axis of the leg in Drosophila melanogaster.";
RL Genetics 173:255-266(2006).
RN [12]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16648585; DOI=10.1534/genetics.106.057893;
RA Sun X., Morozova T., Sonnenfeld M.J.;
RT "Glial and neuronal functions of the Drosophila homolog of the human
RT SWI/SNF gene ATR-X (DATR-X) and the jing zinc-finger gene specify the
RT lateral positioning of longitudinal glia and axons.";
RL Genetics 173:1397-1415(2006).
RN [13]
RP FUNCTION.
RX PubMed=18036784; DOI=10.1016/j.mod.2007.10.003;
RA McClure K.D., Schubiger G.;
RT "A screen for genes that function in leg disc regeneration in Drosophila
RT melanogaster.";
RL Mech. Dev. 125:67-80(2008).
CC -!- FUNCTION: May functionally interact with Polycomb group (PcG) and
CC trithorax group (trxG) proteins to repress transcription (Probable).
CC Required for Egfr pathway function and MAPK activity in CNS midline and
CC tracheal placodes and for CNS axon development and tracheal tubule
CC development. Required to establish the primary axon scaffold in the
CC brain and for lateral positioning of longitudinal glia, longitudinal
CC axons and neurons. Required for glial survival. Required to establish
CC the proximo-distal axis of the developing leg and for wing vein and
CC alula development. Required for regenerative growth in leg imaginal
CC disks. Required for the initiation of anterior migration of border
CC cells of the ovary. {ECO:0000269|PubMed:11152631,
CC ECO:0000269|PubMed:12015288, ECO:0000269|PubMed:12111212,
CC ECO:0000269|PubMed:15511644, ECO:0000269|PubMed:16510782,
CC ECO:0000269|PubMed:16648585, ECO:0000269|PubMed:18036784, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11152631,
CC ECO:0000269|PubMed:12015288}.
CC -!- TISSUE SPECIFICITY: Expressed in the imaginal disks of the leg and
CC wing. {ECO:0000269|PubMed:16510782}.
CC -!- DEVELOPMENTAL STAGE: Expressed from precellular blastoderm stages.
CC Expressed in the CNS midline, neuroectoderm, supraoesophogal ganglion
CC and trachea from embryonic stage 9. Expressed in the tracheal placodes
CC from stage 10. Expressed in a subset of posterior glia in the brain and
CC a subset of anterior neurons at stage 11. Expressed in CNS midline
CC cells and segmental ectodermal stripes during stages 12 and 13 and in
CC dorsally positioned midline glia and ventrally positioned midline
CC neurons from stage 14. Expressed in posterior and anterior glia and
CC neurons at stage 15. {ECO:0000269|PubMed:12015288,
CC ECO:0000269|PubMed:12111212, ECO:0000269|PubMed:16648585}.
CC -!- INDUCTION: Induced in ventrally positioned cells in pair-rule
CC ectodermal stripes by expression of sim.
CC -!- SIMILARITY: Belongs to the AEBP2/jing C2H2-type zinc-finger family.
CC {ECO:0000305}.
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DR EMBL; AF356082; AAK49526.1; -; mRNA.
DR EMBL; AF285778; AAG45962.1; -; mRNA.
DR EMBL; AE013599; AAS64777.2; -; Genomic_DNA.
DR EMBL; AY061438; AAL28986.1; -; mRNA.
DR EMBL; BT025201; ABF17892.1; -; mRNA.
DR RefSeq; NP_001097199.1; NM_001103729.2.
DR RefSeq; NP_995749.2; NM_206027.3.
DR AlphaFoldDB; Q7KHG2; -.
DR SMR; Q7KHG2; -.
DR BioGRID; 61456; 32.
DR IntAct; Q7KHG2; 11.
DR STRING; 7227.FBpp0112914; -.
DR PaxDb; Q7KHG2; -.
DR EnsemblMetazoa; FBtr0114364; FBpp0112913; FBgn0086655.
DR EnsemblMetazoa; FBtr0301636; FBpp0290850; FBgn0086655.
DR GeneID; 35555; -.
DR KEGG; dme:Dmel_CG9397; -.
DR UCSC; CG9397-RD; d. melanogaster.
DR CTD; 35555; -.
DR FlyBase; FBgn0086655; jing.
DR VEuPathDB; VectorBase:FBgn0086655; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_246373_0_0_1; -.
DR InParanoid; Q7KHG2; -.
DR Reactome; R-DME-212300; PRC2 methylates histones and DNA.
DR SignaLink; Q7KHG2; -.
DR BioGRID-ORCS; 35555; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35555; -.
DR PRO; PR:Q7KHG2; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0086655; Expressed in ventral midline and 62 other tissues.
DR ExpressionAtlas; Q7KHG2; baseline and differential.
DR Genevisible; Q7KHG2; DM.
DR GO; GO:0035098; C:ESC/E(Z) complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:FlyBase.
DR GO; GO:0007411; P:axon guidance; IMP:FlyBase.
DR GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase.
DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0008347; P:glial cell migration; IMP:FlyBase.
DR GO; GO:0007474; P:imaginal disc-derived wing vein specification; IMP:FlyBase.
DR GO; GO:0007479; P:leg disc proximal/distal pattern formation; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0007424; P:open tracheal system development; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007382; P:specification of segmental identity, maxillary segment; IGI:FlyBase.
DR GO; GO:0042246; P:tissue regeneration; IMP:UniProtKB.
DR GO; GO:0007418; P:ventral midline development; IMP:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Chromatin regulator; Developmental protein; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1486
FT /note="Zinc finger protein jing"
FT /id="PRO_0000341595"
FT ZN_FING 1148..1172
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1181..1208
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1214..1238
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1242..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1397..1486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1430
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1434..1454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 357
FT /note="T -> K (in Ref. 1; AAK49526)"
FT /evidence="ECO:0000305"
FT CONFLICT 801
FT /note="S -> L (in Ref. 5; AAL28986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1486 AA; 155258 MW; 8FB5F1BF0F8495D5 CRC64;
MPPHILGSAS GSSSTAAASP PTSSASQTPP SPAIHHSHLS QHNATSAMSK PTTPQRHGNP
SLLPTLQWPW NTSLGSTSTA VPAASANKNK RTAAGSGAAL GLSGEGSCLT GGGAASAKKA
RSDLPGSFDA SKRLKVAAME ESQTKITGFF KSQMKPSPGG GKLSPQPGQQ SNPANTLTMS
TPATTASLNK YFNILSQLKE QKAQQQQQQQ QASKTLPTPA PVAPVPSAPP VAPVVVTPSP
SLPVPALKKI ERSNKQPAKI AQVAPNLRKT PSSGSSGSSS SSSSSSSNGS NTGKSPTKKH
VAIAPRTPEM KQQQQQGKAA MVYRPPVTST ALKQKQISPP APVAAHTPAP APALNPTPAP
ANPTLYQLPV QLPNLVQLPP QLAAAANIMQ LNNVAKAAVA AAATNNAAAQ AAQAAQAAAA
QYFLNGTVFK LQQVTTATTT TATTATAAAA PAGNPFGLLN LATAGNPFGL PNANGQFPIE
AIPGAGSYLH HQLLLARQNN MSLNETMASN SCGNMNFVNP LNNQQVGLKD NKLYIVNSAE
YLGYLMSLQI ALNNQQHQQQ QIISATQPPP LAATNNNSTN TATQPPPLAA TNNTNSNTAN
NSTASNSINH NASNNLSNIN NTAIQPQRAI VKPPLHSSTQ PPPLVTISSM PACSPAAASS
PAAKRSLPAA KPYQKRLTAK GRVGTAPIIA TPTTPPPLVP TSATKELGQL RKSTGTTGTP
TGTPTPTPPL VSIAPSKLTP TLSVSKQGPT MKLANSAPDL FDLVKNSKLV AKVSQPLTPL
PFSSPSSSSN GSHGSHGMRS SPALSTSNSC TLSAFSKIKV ETTELASQTG SLTSSSIPTI
SLKPQSFAGQ LPKREPESET DTLKHDLLPD CTNSNSNSNS CSSSTYSHSV SSAADLSLEA
STPAPSPSPS ASPSGLGSPS PAASNLSASS RRAASQTDML SELVTSSCIS SGGDDCSQAT
DSPPMPALPL AKSEDATTPI STVSGGSSSG SSNYDEEDDK SVASLETHQT HKRLRDLPTP
ESGIGGSLSN SESSNSIADA ISSKSASVGP PTTAASSASS SASDSNSLAS NAPSPASPED
CSAAPSPACS ASTTGSIPPS TVVDIAMVEA TSKSLPKSAI SPILSQPKTI RFPAGAGASG
KGGKRHDGVC YWDKCNKKHE SNSKLLDHMQ THHVNTQTGP FACLWVGCKV YNKESCSRRW
LERHVLSHGG SKQFKCIVEG CGLRFGSQLA LQKHVNNHFN ATDNARESTS KRTSDPPVPK
QLRKNGKKLR YRRQPFSARM FDFFDTGIME GLQHRLRQIS TLTNGAQAIE FQGQCMMRRR
NSQGGYECFV RWSPREIISD EWLPECLNRT RQHTKVLHIK QMRPAEKTRV DSLLSTAFRL
RYDSHLFADD YNVNEQQVGE ASGSDCDEDG DGDQEEEDLE DQDEDEEEDG SSSSRSASCE
TVSSYQQVLS IAKLQMQQRR KHPRKPPKVT PPAREKLVPT DALVPI
