ID   JIP5_AJECN              Reviewed;         413 AA.
AC   A6RDW5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=WD repeat-containing protein JIP5;
GN   Name=JIP5; ORFNames=HCAG_07823;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; CH476663; EDN11370.1; -; Genomic_DNA.
DR   RefSeq; XP_001537514.1; XM_001537464.1.
DR   AlphaFoldDB; A6RDW5; -.
DR   SMR; A6RDW5; -.
DR   STRING; 339724.A6RDW5; -.
DR   EnsemblFungi; EDN11370; EDN11370; HCAG_07823.
DR   GeneID; 5443881; -.
DR   KEGG; aje:HCAG_07823; -.
DR   VEuPathDB; FungiDB:HCAG_07823; -.
DR   HOGENOM; CLU_052691_0_0_1; -.
DR   OMA; QTHHPHD; -.
DR   OrthoDB; 1173229at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..413
FT                   /note="WD repeat-containing protein JIP5"
FT                   /id="PRO_0000333544"
FT   REPEAT          9..48
FT                   /note="WD 1"
FT   REPEAT          66..105
FT                   /note="WD 2"
FT   REPEAT          114..155
FT                   /note="WD 3"
FT   REPEAT          218..259
FT                   /note="WD 4"
FT   REPEAT          268..311
FT                   /note="WD 5"
FT   REPEAT          315..352
FT                   /note="WD 6"
FT   REGION          150..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          348..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..383
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..398
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  44091 MW;  59EC08DBCF237488 CRC64;
     MFDNVCSLPL SSDLFAQAIH PTEPLVAVGL SSGHVQTFRI PPSSDSGPGA TKNGLGHIDT
     AWRTRRHKAS CRCLGFGIDG QTLYSAGADG WVKAAKAETG VVNLKIAVPR LGEGTHDRID
     PPTVIHAISP ETIILSTDSG ALHLFDLRVP PSPVSQRPQQ THHPHDDYVS SLTPLPPSET
     STSGFSKQWV TTGGTTIAVT DLRRGVLVRS EDQDEELISS VYVTGLKAGG TSRGEKLVVG
     GASGVLTLWE KGAWDDQDER IIVDRQPDGG ESLEILSLLP DSIGAGKVVA VGQSDGAVQF
     VQLGVNKVIS KVVHDELEGI AGLGFDVGGR MISGGGSIVK VWHEAVEREG HGENEEDEQH
     SRKRFVMGSD DDGNDDSSVD GQKQNKKKRK KRKKGKSKDK SDGQHVMAFK GLD