ID   JIP5_ASHGO              Reviewed;         508 AA.
AC   Q758M2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 3.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=WD repeat-containing protein JIP5;
GN   Name=JIP5; OrderedLocusNames=AEL261C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 473-492 AND 500.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52424.2; -; Genomic_DNA.
DR   RefSeq; NP_984600.2; NM_209953.2.
DR   AlphaFoldDB; Q758M2; -.
DR   SMR; Q758M2; -.
DR   STRING; 33169.AAS52424; -.
DR   EnsemblFungi; AAS52424; AAS52424; AGOS_AEL261C.
DR   GeneID; 4620781; -.
DR   KEGG; ago:AGOS_AEL261C; -.
DR   eggNOG; KOG2444; Eukaryota.
DR   HOGENOM; CLU_035623_0_0_1; -.
DR   InParanoid; Q758M2; -.
DR   OMA; QTHHPHD; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR017422; WDR55.
DR   PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..508
FT                   /note="WD repeat-containing protein JIP5"
FT                   /id="PRO_0000333545"
FT   REPEAT          46..94
FT                   /note="WD 1"
FT   REPEAT          105..144
FT                   /note="WD 2"
FT   REPEAT          150..189
FT                   /note="WD 3"
FT   REPEAT          194..234
FT                   /note="WD 4"
FT   REPEAT          252..293
FT                   /note="WD 5"
FT   REPEAT          344..381
FT                   /note="WD 6"
FT   REGION          372..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..420
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..478
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   508 AA;  56070 MW;  5D99E4CB78BA8AEF CRC64;
     MGKKKNSKAY SEELTDTTRP LLEFRYGNPL FAIACHPEQS VIVSGLATGH MFCHKYNAAE
     LKEAQLKRLR KHDAGSKDDR KKLWEVVEVP GVETSGVSLL WTTKRHKGSV RCICFDADGT
     HIYSVGTDNV LKKADTLTGK VVKKCVLDPG QNVKYTKLVK SATHPLVLLG DENGNVTVLN
     SESLEQTNLI KSIHNGDAIN DIFHFAKKSV YRYISLGQTT LAHWDSRESN EGDFAIAADD
     KQAKRKVILS DDQEDEILCG TFVDPEDGEV LVCGMGEGVL TVWRPKKNGL ADQLTRIKVK
     KNESIDCIVP TLEDDGCVWC GCSDGNIYKV HVNRGTIIEV RKHSKLDEVT FLDLDSEYRL
     LSGGLDKAKL WDSEKSEQLT PGSDADDRVS NSSPSAGKSS ESDSNDSEND ATSSGGSSDE
     DSSSDESEHS DASDVEEELV GLTREQIIAE LDKDLVEESE DVEDVRSQRK RKHGADLPTN
     ANGKKQKGKN IKPERSMKTH GIRRFEGL