ID   JIP5_COCIM              Reviewed;         416 AA.
AC   Q1DNW5; J3K5A0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=WD repeat-containing protein JIP5;
GN   Name=JIP5; ORFNames=CIMG_07998;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; GG704913; EAS29252.3; -; Genomic_DNA.
DR   RefSeq; XP_001240835.1; XM_001240834.2.
DR   AlphaFoldDB; Q1DNW5; -.
DR   SMR; Q1DNW5; -.
DR   STRING; 246410.Q1DNW5; -.
DR   EnsemblFungi; EAS29252; EAS29252; CIMG_07998.
DR   GeneID; 4559472; -.
DR   KEGG; cim:CIMG_07998; -.
DR   VEuPathDB; FungiDB:CIMG_07998; -.
DR   InParanoid; Q1DNW5; -.
DR   OMA; QTHHPHD; -.
DR   OrthoDB; 1173229at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..416
FT                   /note="WD repeat-containing protein JIP5"
FT                   /id="PRO_0000333555"
FT   REPEAT          9..48
FT                   /note="WD 1"
FT   REPEAT          62..101
FT                   /note="WD 2"
FT   REPEAT          112..151
FT                   /note="WD 3"
FT   REPEAT          214..255
FT                   /note="WD 4"
FT   REPEAT          264..308
FT                   /note="WD 5"
FT   REPEAT          309..348
FT                   /note="WD 6"
FT   REGION          149..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          343..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..358
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   416 AA;  44563 MW;  5E753EE610FF51CD CRC64;
     MFDTVCSLPL SSDLFSQAIH PTEPLVSIGL SSGHVQTFHL PAPSENGKAG YGHIDTVWRT
     RRHKGSCRCV GFGIDGETLY SAGTDGWVKA ARTETGRVEW KFAVPRIGDK SGFQVDSPCL
     IHALSPQTLL LATDSGALHL FDLRDRSTEV SARPQQTHHP HDDYVSSLTP LPPSETSTSG
     YSKQWITTGG TTIAVTDLRR GILVRSEDQG EELISSSYVT GLKAGGTSKG EKLVVGGASG
     VLTLWEKGAW DDQDERIIVD RSLDGGESLE VIANVPDELG KGKVVAVGQS DGRVQFVQLG
     PNKVISELSH DDLEGVVGLG FDVQGRMISG GGTVVKVWHE AISDEEGNDD ESDEEDIENG
     EGLGKKRKGG NGSSDEEEDS DDDMAGKDKG KRKKRKRGKG KDRSGGVHVM AFKGLD