ID   JIP5_CRYNB              Reviewed;         374 AA.
AC   P0CS41; Q55ZY2; Q5KP90;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=WD repeat-containing protein JIP5;
GN   Name=JIP5; OrderedLocusNames=CNBA3580;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; AAEY01000002; EAL23242.1; -; Genomic_DNA.
DR   RefSeq; XP_777889.1; XM_772796.1.
DR   AlphaFoldDB; P0CS41; -.
DR   SMR; P0CS41; -.
DR   EnsemblFungi; EAL23242; EAL23242; CNBA3580.
DR   GeneID; 4933616; -.
DR   KEGG; cnb:CNBA3580; -.
DR   HOGENOM; CLU_035848_2_1_1; -.
DR   Proteomes; UP000001435; Chromosome 1.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR017422; WDR55.
DR   Pfam; PF00400; WD40; 2.
DR   PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Repeat; WD repeat.
FT   CHAIN           1..374
FT                   /note="WD repeat-containing protein JIP5"
FT                   /id="PRO_0000410333"
FT   REPEAT          21..61
FT                   /note="WD 1"
FT   REPEAT          68..107
FT                   /note="WD 2"
FT   REPEAT          120..158
FT                   /note="WD 3"
FT   REPEAT          161..200
FT                   /note="WD 4"
FT   REPEAT          205..244
FT                   /note="WD 5"
FT   REPEAT          249..287
FT                   /note="WD 6"
FT   REPEAT          290..330
FT                   /note="WD 7"
FT   REGION          325..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..341
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..360
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   374 AA;  41505 MW;  1D1F83B5738E2EB1 CRC64;
     MPDIKLKNQA SLCASTRLFL AYTSIKPFDV AFHPKEPVVF SSLLTGQVCA WSYDDATGET
     SSSWSVRPSK RTARALSIEE NGDEIWMGGK SGSLLCALTP PKVIQLSTRD GSMTRERDSA
     HECPINRVYC VNRNLVATGD DDGVIKLWDP RQADSIRTYS QHFDYISDFT YFDDKRQLVA
     TSGDGHLSVI DIRSNKSTPL TVSEDQEDEL LSIVPIKGGQ KAIVGSGLGI LSVWNRQMGW
     ADSVDRIPGH PASIDAIVAL TPDIIATGSE DGMIRVIQVL PHKFLGVVAT HEEFPVERIR
     LDRNNKWLGS VSHDECLKLT DVEDLFEDSD EDDEMEEDEP DSDEEKSKKK KKDNGMKDMS
     RGQAENDGSF FADL