ID   JIP5_KLULA              Reviewed;         525 AA.
AC   Q6CVN2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=WD repeat-containing protein JIP5;
GN   Name=JIP5; OrderedLocusNames=KLLA0B10736g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02400.1; -; Genomic_DNA.
DR   RefSeq; XP_452007.1; XM_452007.1.
DR   AlphaFoldDB; Q6CVN2; -.
DR   SMR; Q6CVN2; -.
DR   STRING; 28985.XP_452007.1; -.
DR   EnsemblFungi; CAH02400; CAH02400; KLLA0_B10736g.
DR   GeneID; 2897437; -.
DR   KEGG; kla:KLLA0_B10736g; -.
DR   eggNOG; KOG2444; Eukaryota.
DR   HOGENOM; CLU_035623_0_0_1; -.
DR   InParanoid; Q6CVN2; -.
DR   OMA; TRIKVNK; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..525
FT                   /note="WD repeat-containing protein JIP5"
FT                   /id="PRO_0000333560"
FT   REPEAT          28..69
FT                   /note="WD 1"
FT   REPEAT          121..160
FT                   /note="WD 2"
FT   REPEAT          211..251
FT                   /note="WD 3"
FT   REPEAT          270..310
FT                   /note="WD 4"
FT   REPEAT          358..398
FT                   /note="WD 5"
FT   REGION          396..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..488
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..503
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        504..525
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   525 AA;  58892 MW;  A62D6902115C8E82 CRC64;
     MGKNTKAKKR AASLEVLASK SSPILEFVFD EPLIHVACHP EQPIVVCAIA TGHVFCCKYD
     AKALKRILNK NEAKLAALEN KDDQKRKRFW KLIKLKAEMD TYELEEGEET AAVELLWKTR
     RHKGSVRGMS FNNDGSKLYT IGIDNVLKKA NSLTGKVMKK VTLPLSSEKN HYTKLVTSKT
     HPFLLLGDEL GNIHVLNNDT LQLQNTIKSI HNGDAINDIF QFVGKSVYKF ISLGQTTLAY
     WDSRESNESD ASIPADDLDA KRKVYVSDDQ EDEMICGSFV NPEDGDILVC GMGEGVLTVW
     KPKKNDLVDQ VTRIPICKNE SVDCVISSFQ DDNCVYCGCS NGNVYKVNVK LGKVIEIRKH
     SSIDEVSFID LDYEYRVLSA GMDKVKLWDI VDEDDDEEGK INESYSNSES DNDNGFDSDA
     DSNSDSESVS SSDVDSASDD EENSKSESEA NESDVEETLV GLSKDELLAE LEKDLQSSDE
     DSKHYTKRTK STQPKKLKKQ KKELNNKQLR NLQKHEHGIR KFEGL