JIP5_YEAST
ID JIP5_YEAST Reviewed; 492 AA.
AC Q06214; D6W4H0;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=WD repeat-containing protein JIP5;
DE AltName: Full=Jumonji domain-interacting protein 5;
GN Name=JIP5; OrderedLocusNames=YPR169W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=14690591; DOI=10.1016/s1097-2765(03)00476-3;
RA Hazbun T.R., Malmstroem L., Anderson S., Graczyk B.J., Fox B., Riffle M.,
RA Sundin B.A., Aranda J.D., McDonald W.H., Chiu C.-H., Snydsman B.E.,
RA Bradley P., Muller E.G.D., Fields S., Baker D., Yates J.R. III, Davis T.N.;
RT "Assigning function to yeast proteins by integration of technologies.";
RL Mol. Cell 12:1353-1365(2003).
RN [4]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=15905473; DOI=10.1093/nar/gki583;
RA Zhang Z., Dietrich F.S.;
RT "Mapping of transcription start sites in Saccharomyces cerevisiae using 5'
RT SAGE.";
RL Nucleic Acids Res. 33:2838-2851(2005).
RN [8]
RP INTERACTION WITH BUD27 AND GIS1.
RX PubMed=17043893; DOI=10.1007/s00438-006-0171-3;
RA Tronnersjoe S., Hanefalk C., Balciunas D., Hu G.-Z., Nordberg N., Muren E.,
RA Ronne H.;
RT "The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact
RT with 19 proteins involved in transcription, sumoylation and DNA repair.";
RL Mol. Genet. Genomics 277:57-70(2007).
CC -!- SUBUNIT: Interacts with BUD27 and GIS1. {ECO:0000269|PubMed:17043893}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 7750 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB68156.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U25840; AAB68156.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006949; DAA11586.1; -; Genomic_DNA.
DR PIR; S59828; S59828.
DR RefSeq; NP_015495.2; NM_001184266.1.
DR AlphaFoldDB; Q06214; -.
DR SMR; Q06214; -.
DR BioGRID; 36342; 83.
DR DIP; DIP-3805N; -.
DR IntAct; Q06214; 3.
DR MINT; Q06214; -.
DR STRING; 4932.YPR169W; -.
DR MaxQB; Q06214; -.
DR PaxDb; Q06214; -.
DR PRIDE; Q06214; -.
DR EnsemblFungi; YPR169W_mRNA; YPR169W; YPR169W.
DR GeneID; 856298; -.
DR KEGG; sce:YPR169W; -.
DR SGD; S000006373; JIP5.
DR VEuPathDB; FungiDB:YPR169W; -.
DR eggNOG; KOG2444; Eukaryota.
DR GeneTree; ENSGT00940000153727; -.
DR HOGENOM; CLU_035623_0_0_1; -.
DR InParanoid; Q06214; -.
DR OMA; QTHHPHD; -.
DR BioCyc; YEAST:G3O-34297-MON; -.
DR PRO; PR:Q06214; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q06214; protein.
DR GO; GO:0005730; C:nucleolus; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IMP:SGD.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..492
FT /note="WD repeat-containing protein JIP5"
FT /id="PRO_0000257817"
FT REPEAT 127..166
FT /note="WD 1"
FT REPEAT 178..217
FT /note="WD 2"
FT REPEAT 236..274
FT /note="WD 3"
FT REPEAT 276..317
FT /note="WD 4"
FT REPEAT 365..405
FT /note="WD 5"
FT REGION 404..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..429
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 55264 MW; 52C8B2B01211B103 CRC64;
MAKSKKKTDV VDSTNLPILE LLSLKAPIFQ SLLHPELPII ITGFGTGHIV CHRYDPAKLQ
SHLDRRRRID TATTGKDAKK GVCPWIRLDI DLETGDLKFV DIEEQQQQKQ TGKDEDLGVK
TLWKTKRHKG SVRAMCFDSK GDNIFSVGSD NVLKKANTMT GKVVKKVNLS SLFNSEEKKN
DKFTKLCASQ THPFILIGDE SGNIHVINSE NLALSNSIRS IHFGDSINDI FHFDKRSAYK
FISLGQTTLA YFDVRDKDAK PNVAGNEDGK ILISDDQEDE VLCGCFVDPE VADTLLCGMG
EGIVTVWKPN KNDLEDQMSR IKISKDESID CIVPTLQDDN CVWCGCSNGN IYKVNAKLGK
VVEIRNHSEL DEVSFVDLDF EYRVVSGGLE NIKIWELSSD DVEENASVES DSDEPLSHSD
EDLSDDTSSD DETTLVGLSK EELLDELDKD LKEDHQEEKE SNSKSVKKRK IMKENNKKKD
LYEHGIKKFD DL
