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JIP_CAEEL
ID   JIP_CAEEL               Reviewed;        1190 AA.
AC   P34609; A7LPE3; A7LPE4; C0P271; C7FZT6; Q95V72; S6EZN6; S6EZP3; S6F548;
AC   S6F556; S6FD02; S6FN04; S6FN08; S6FWP4; S6FWP6; U4MKU8;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2019, sequence version 4.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=JNK-interacting protein;
DE            Short=JIP;
DE   AltName: Full=JNK MAP kinase scaffold protein;
DE   AltName: Full=Uncoordinated protein 16;
GN   Name=unc-16 {ECO:0000312|WormBase:ZK1098.10e};
GN   Synonyms=egl-39 {ECO:0000312|WormBase:ZK1098.10e};
GN   ORFNames=ZK1098.10 {ECO:0000312|WormBase:ZK1098.10e};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH JNK-1;
RP   JKK-1 AND SEK-1, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=10393177; DOI=10.1093/emboj/18.13.3604;
RA   Kawasaki M., Hisamoto N., Iino Y., Yamamoto M., Ninomiya-Tsuji J.,
RA   Matsumoto K.;
RT   "A Caenorhabditis elegans JNK signal transduction pathway regulates
RT   coordinated movement via type-D GABAergic motor neurons.";
RL   EMBO J. 18:3604-3615(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH
RP   JNK-1; JKK-1 AND SEK-1.
RX   PubMed=11738026; DOI=10.1016/s0896-6273(01)00532-3;
RA   Byrd D.T., Kawasaki M., Walcoff M., Hisamoto N., Matsumoto K., Jin Y.;
RT   "UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in
RT   C. elegans.";
RL   Neuron 32:787-800(2001).
RN   [5]
RP   FUNCTION, AND MUTAGENESIS OF LEU-75 AND 765-TRP--LYS-1157.
RX   PubMed=30880001; DOI=10.1016/j.devcel.2019.02.013;
RA   Hill S.E., Kauffman K.J., Krout M., Richmond J.E., Melia T.J.,
RA   Colon-Ramos D.A.;
RT   "Maturation and Clearance of Autophagosomes in Neurons Depends on a
RT   Specific Cysteine Protease Isoform, ATG-4.2.";
RL   Dev. Cell 49:251-266(2019).
CC   -!- FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins
CC       selectively mediates JNK signaling by aggregating specific components
CC       of the MAPK cascade to form a functional JNK signaling module. May
CC       function as a regulator of synaptic vesicle transport, through
CC       interactions with the JNK-signaling components and motor proteins.
CC       Binds specific components of the JNK signaling pathway namely jnk-1,
CC       jkk-1 and sek-1. Associates with components of the motor protein,
CC       kinesin-1. Pre-assembled unc-16 scaffolding complexes are then
CC       transported as a cargo of kinesin, to the required subcellular
CC       location. Regulates the retrograde transport of autophagosomes from the
CC       neurites to the cell body of AIY interneurons (PubMed:30880001).
CC       {ECO:0000269|PubMed:10393177, ECO:0000269|PubMed:11738026,
CC       ECO:0000269|PubMed:30880001}.
CC   -!- INTERACTION:
CC       P34609; P46822: klc-2; NbExp=4; IntAct=EBI-315684, EBI-315578;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000269|PubMed:10393177, ECO:0000269|PubMed:11738026}.
CC       Note=Diffusely localized throughout cell body but intensely localized
CC       in regions adjacent to nucleus and at presumptive tips of neural
CC       processes.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=16;
CC       Name=e {ECO:0000312|WormBase:ZK1098.10e};
CC         IsoId=P34609-1; Sequence=Displayed;
CC       Name=a {ECO:0000312|WormBase:ZK1098.10a};
CC         IsoId=P34609-3; Sequence=VSP_060417, VSP_060421;
CC       Name=b {ECO:0000312|WormBase:ZK1098.10b};
CC         IsoId=P34609-5; Sequence=VSP_060422;
CC       Name=c {ECO:0000312|WormBase:ZK1098.10c};
CC         IsoId=P34609-6; Sequence=VSP_060414;
CC       Name=d {ECO:0000312|WormBase:ZK1098.10d};
CC         IsoId=P34609-7; Sequence=VSP_060422, VSP_060428;
CC       Name=f {ECO:0000312|WormBase:ZK1098.10f};
CC         IsoId=P34609-8; Sequence=VSP_060416, VSP_060422;
CC       Name=g {ECO:0000312|WormBase:ZK1098.10g};
CC         IsoId=P34609-9; Sequence=VSP_060415;
CC       Name=h {ECO:0000312|WormBase:ZK1098.10h};
CC         IsoId=P34609-10; Sequence=VSP_060419, VSP_060426, VSP_060427;
CC       Name=i {ECO:0000312|WormBase:ZK1098.10i};
CC         IsoId=P34609-11; Sequence=VSP_060425;
CC       Name=j {ECO:0000312|WormBase:ZK1098.10j};
CC         IsoId=P34609-12; Sequence=VSP_060417, VSP_060420, VSP_060424,
CC                                   VSP_060426, VSP_060427;
CC       Name=k {ECO:0000312|WormBase:ZK1098.10k};
CC         IsoId=P34609-13; Sequence=VSP_060416, VSP_060420, VSP_060424,
CC                                   VSP_060426, VSP_060427;
CC       Name=l {ECO:0000312|WormBase:ZK1098.10l};
CC         IsoId=P34609-14; Sequence=VSP_060423, VSP_060426, VSP_060427;
CC       Name=m {ECO:0000312|WormBase:ZK1098.10m};
CC         IsoId=P34609-15; Sequence=VSP_060418, VSP_060420, VSP_060424,
CC                                   VSP_060426, VSP_060427;
CC       Name=n {ECO:0000312|WormBase:ZK1098.10n};
CC         IsoId=P34609-16; Sequence=VSP_060421, VSP_060426, VSP_060427;
CC       Name=o {ECO:0000312|WormBase:ZK1098.10o};
CC         IsoId=P34609-17; Sequence=VSP_060415, VSP_060424;
CC       Name=p {ECO:0000312|WormBase:ZK1098.10p};
CC         IsoId=P34609-18; Sequence=VSP_060414, VSP_060428;
CC   -!- TISSUE SPECIFICITY: Expressed in neurons of the ventral cord,
CC       retrovesicular and preanal ganglia and nerve ring, intestinal cells,
CC       seam and hypodermal cells, body wall, head muscle and pharynx.
CC       {ECO:0000269|PubMed:10393177, ECO:0000269|PubMed:11738026}.
CC   -!- SIMILARITY: Belongs to the JIP scaffold family. {ECO:0000305}.
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DR   EMBL; AF424978; AAL23934.1; -; mRNA.
DR   EMBL; BX284603; CAA80140.1; -; Genomic_DNA.
DR   EMBL; BX284603; CAD45611.1; -; Genomic_DNA.
DR   EMBL; BX284603; CAO82057.1; -; Genomic_DNA.
DR   EMBL; BX284603; CAO82058.1; -; Genomic_DNA.
DR   EMBL; BX284603; CAX51690.1; -; Genomic_DNA.
DR   EMBL; BX284603; CBA11621.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24108.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24109.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24110.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24111.2; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24112.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24113.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24114.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24115.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24116.1; -; Genomic_DNA.
DR   EMBL; BX284603; CDG24117.1; -; Genomic_DNA.
DR   PIR; S40932; S40932.
DR   RefSeq; NP_001022981.1; NM_001027810.3. [P34609-5]
DR   RefSeq; NP_001122747.1; NM_001129275.2. [P34609-6]
DR   RefSeq; NP_001122748.1; NM_001129276.1. [P34609-7]
DR   RefSeq; NP_001255008.1; NM_001268079.1. [P34609-1]
DR   RefSeq; NP_001255009.1; NM_001268080.1. [P34609-8]
DR   RefSeq; NP_001293608.1; NM_001306679.1. [P34609-9]
DR   RefSeq; NP_001293609.1; NM_001306680.1. [P34609-10]
DR   RefSeq; NP_001293610.1; NM_001306681.1.
DR   RefSeq; NP_001293611.1; NM_001306682.1. [P34609-12]
DR   RefSeq; NP_001293612.1; NM_001306683.1. [P34609-13]
DR   RefSeq; NP_001293613.1; NM_001306684.1. [P34609-14]
DR   RefSeq; NP_001293614.1; NM_001306685.1. [P34609-15]
DR   RefSeq; NP_001293615.1; NM_001306686.1. [P34609-16]
DR   RefSeq; NP_001293616.1; NM_001306687.1. [P34609-17]
DR   RefSeq; NP_001293617.1; NM_001306688.1. [P34609-18]
DR   RefSeq; NP_741263.3; NM_171221.4. [P34609-3]
DR   AlphaFoldDB; P34609; -.
DR   BioGRID; 41544; 14.
DR   DIP; DIP-25590N; -.
DR   IntAct; P34609; 6.
DR   STRING; 6239.ZK1098.10e; -.
DR   iPTMnet; P34609; -.
DR   EPD; P34609; -.
DR   PaxDb; P34609; -.
DR   PeptideAtlas; P34609; -.
DR   EnsemblMetazoa; ZK1098.10a.1; ZK1098.10a.1; WBGene00006755. [P34609-3]
DR   EnsemblMetazoa; ZK1098.10a.2; ZK1098.10a.2; WBGene00006755. [P34609-3]
DR   EnsemblMetazoa; ZK1098.10b.1; ZK1098.10b.1; WBGene00006755. [P34609-5]
DR   EnsemblMetazoa; ZK1098.10c.1; ZK1098.10c.1; WBGene00006755. [P34609-6]
DR   EnsemblMetazoa; ZK1098.10d.1; ZK1098.10d.1; WBGene00006755. [P34609-7]
DR   EnsemblMetazoa; ZK1098.10e.1; ZK1098.10e.1; WBGene00006755. [P34609-1]
DR   EnsemblMetazoa; ZK1098.10f.1; ZK1098.10f.1; WBGene00006755. [P34609-8]
DR   EnsemblMetazoa; ZK1098.10g.1; ZK1098.10g.1; WBGene00006755. [P34609-9]
DR   EnsemblMetazoa; ZK1098.10h.1; ZK1098.10h.1; WBGene00006755. [P34609-10]
DR   EnsemblMetazoa; ZK1098.10i.1; ZK1098.10i.1; WBGene00006755. [P34609-11]
DR   EnsemblMetazoa; ZK1098.10j.1; ZK1098.10j.1; WBGene00006755. [P34609-12]
DR   EnsemblMetazoa; ZK1098.10k.1; ZK1098.10k.1; WBGene00006755. [P34609-13]
DR   EnsemblMetazoa; ZK1098.10l.1; ZK1098.10l.1; WBGene00006755. [P34609-14]
DR   EnsemblMetazoa; ZK1098.10m.1; ZK1098.10m.1; WBGene00006755. [P34609-15]
DR   EnsemblMetazoa; ZK1098.10n.1; ZK1098.10n.1; WBGene00006755. [P34609-16]
DR   EnsemblMetazoa; ZK1098.10o.1; ZK1098.10o.1; WBGene00006755. [P34609-17]
DR   EnsemblMetazoa; ZK1098.10p.1; ZK1098.10p.1; WBGene00006755. [P34609-18]
DR   GeneID; 176349; -.
DR   KEGG; cel:CELE_ZK1098.10; -.
DR   UCSC; ZK1098.10b.1; c. elegans.
DR   CTD; 176349; -.
DR   WormBase; ZK1098.10a; CE00363; WBGene00006755; unc-16. [P34609-3]
DR   WormBase; ZK1098.10b; CE31846; WBGene00006755; unc-16. [P34609-5]
DR   WormBase; ZK1098.10c; CE41490; WBGene00006755; unc-16. [P34609-6]
DR   WormBase; ZK1098.10d; CE41491; WBGene00006755; unc-16. [P34609-7]
DR   WormBase; ZK1098.10e; CE43483; WBGene00006755; unc-16. [P34609-1]
DR   WormBase; ZK1098.10f; CE44092; WBGene00006755; unc-16. [P34609-8]
DR   WormBase; ZK1098.10g; CE48500; WBGene00006755; unc-16. [P34609-9]
DR   WormBase; ZK1098.10h; CE48468; WBGene00006755; unc-16. [P34609-10]
DR   WormBase; ZK1098.10i; CE48413; WBGene00006755; unc-16. [P34609-11]
DR   WormBase; ZK1098.10j; CE48699; WBGene00006755; unc-16. [P34609-12]
DR   WormBase; ZK1098.10k; CE48497; WBGene00006755; unc-16. [P34609-13]
DR   WormBase; ZK1098.10l; CE48433; WBGene00006755; unc-16. [P34609-14]
DR   WormBase; ZK1098.10m; CE48429; WBGene00006755; unc-16. [P34609-15]
DR   WormBase; ZK1098.10n; CE48454; WBGene00006755; unc-16. [P34609-16]
DR   WormBase; ZK1098.10o; CE48464; WBGene00006755; unc-16. [P34609-17]
DR   WormBase; ZK1098.10p; CE48473; WBGene00006755; unc-16. [P34609-18]
DR   eggNOG; KOG2077; Eukaryota.
DR   GeneTree; ENSGT00940000153496; -.
DR   HOGENOM; CLU_003841_0_0_1; -.
DR   InParanoid; P34609; -.
DR   OMA; YVTKMLG; -.
DR   OrthoDB; 324912at2759; -.
DR   Reactome; R-CEL-525793; Myogenesis.
DR   SignaLink; P34609; -.
DR   PRO; PR:P34609; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006755; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0030424; C:axon; IDA:WormBase.
DR   GO; GO:0043194; C:axon initial segment; IDA:WormBase.
DR   GO; GO:0043679; C:axon terminus; IDA:WormBase.
DR   GO; GO:0044297; C:cell body; IDA:WormBase.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008432; F:JUN kinase binding; IBA:GO_Central.
DR   GO; GO:0019900; F:kinase binding; IDA:WormBase.
DR   GO; GO:0019894; F:kinesin binding; IMP:UniProtKB.
DR   GO; GO:0005078; F:MAP-kinase scaffold activity; IDA:UniProtKB.
DR   GO; GO:0030159; F:signaling receptor complex adaptor activity; IDA:WormBase.
DR   GO; GO:0030421; P:defecation; IMP:WormBase.
DR   GO; GO:0040011; P:locomotion; IMP:WormBase.
DR   GO; GO:0018991; P:oviposition; IMP:WormBase.
DR   GO; GO:0046328; P:regulation of JNK cascade; IDA:UniProtKB.
DR   GO; GO:0030431; P:sleep; IMP:UniProtKB.
DR   GO; GO:0048489; P:synaptic vesicle transport; IMP:WormBase.
DR   GO; GO:0016192; P:vesicle-mediated transport; IMP:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR039911; JIP3/JIP4.
DR   InterPro; IPR032486; JIP_LZII.
DR   InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR034743; RH1.
DR   InterPro; IPR034744; RH2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR13886; PTHR13886; 1.
DR   Pfam; PF16471; JIP_LZII; 1.
DR   Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS51776; RH1; 1.
DR   PROSITE; PS51777; RH2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..1190
FT                   /note="JNK-interacting protein"
FT                   /id="PRO_0000220637"
FT   DOMAIN          24..112
FT                   /note="RH1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01112"
FT   DOMAIN          456..542
FT                   /note="RH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01113"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          775..829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          78..165
FT                   /evidence="ECO:0000255"
FT   COILED          383..491
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        810..824
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..644
FT                   /note="Missing (in isoform c and isoform p)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060414"
FT   VAR_SEQ         1..350
FT                   /note="Missing (in isoform g and isoform o)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060415"
FT   VAR_SEQ         1..259
FT                   /note="MACNLSPVNEMADSITSSTPSEIVYGGPGSPDEHRTMSDKVQTMASAIYREL
FT                   ETMIKVHGEDGVKTLMPLVVNVLEALDLAYLERDEQTAELEMLKEDNEQLQTQYEREKA
FT                   LRKQTEQKYIEIEDTLIGQNKELDKKIESLESIMRMLELKAKNATDHASRLEEREVEQK
FT                   LEFDRLHERYNTLLRTHVDHMERTKYLMGSEKFELMQNMPLPNMQLRNKMGMAASVDAS
FT                   SIRGVSDLISAHMTQSTTMDVNLANHITNE -> MNSNPQLTFI (in isoform f
FT                   and isoform k)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060416"
FT   VAR_SEQ         1..36
FT                   /note="Missing (in isoform a and isoform j)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060417"
FT   VAR_SEQ         219
FT                   /note="K -> NWFPISHRLHKSGDQSNLSL (in isoform m)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060418"
FT   VAR_SEQ         330..363
FT                   /note="TDDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSL -> TVNDTFI (in
FT                   isoform h)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060419"
FT   VAR_SEQ         330
FT                   /note="T -> TGNLVDPAEFASA (in isoform j, isoform k and
FT                   isoform m)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060420"
FT   VAR_SEQ         331..363
FT                   /note="DDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSL -> GNLVDPAEFASAVND
FT                   TFI (in isoform a and isoform n)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060421"
FT   VAR_SEQ         331..363
FT                   /note="Missing (in isoform b, isoform d and isoform f)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060422"
FT   VAR_SEQ         331..363
FT                   /note="DDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSL -> GNLVDPAEFASA
FT                   (in isoform l)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060423"
FT   VAR_SEQ         363
FT                   /note="L -> LVNDTFI (in isoform j, isoform k, isoform m and
FT                   isoform o)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060424"
FT   VAR_SEQ         554..1190
FT                   /note="SERRAAERREQYKLVREHVKKEDGRIEAYGWSLPNVEAEVSSVPIPVCCRPL
FT                   LDNEPSLKIWCATGVVLRGGRDERGQWIVGDPIYFAPASMKKTKTSNHRPELEDEIKRA
FT                   RNLDARESELDEWQSSSLVWVVSSNQGKSLIAVLDANNPNNIIETFPACDSHLLCIQAV
FT                   SGVMEGEPEMNEEQSKKYLSGGGKIKDLPEGLDGTDLGACEWVELRKMEDSEDGVPTYC
FT                   SNDMKPSPKRTRDFSISEVAPVDSSAPVKEDPLPPPANRPGGRAALPPHIRDAMSKYDG
FT                   VSGQMSGALPTVWMGGQNQYIYIHSAVTAWKQCLRRIKMPDAVLSIVHYKSRIFAALAN
FT                   GTIAIFHRNKHGEWSDEGYHSLRVGSATSSVRSLCLVSTNIWATYKNCVVVLDAESLQI
FT                   VKVFAAHPRKDSQVRNMQWVGAGVWLSIRLDSTLRLYHAHTYEHLQDVDIEPYVTKMLG
FT                   TSKLDFSYMRTTALLVSNRRLWIGTGTGVIISVPFSGQLEKKIETKDSKRPAGPGGLVR
FT                   VYGATSENATNDEKTNDDFIPYCNLAHAQLSFHGHKDSVKFFLGVPGASKNGEDESAEV
FT                   TLRRMLIMSGGDGYIDFRIGEENEPELTGQSIRPRDMSHLIIWEVDAELPILSK -> H
FT                   LSR (in isoform i)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060425"
FT   VAR_SEQ         554..557
FT                   /note="SERR -> HLSR (in isoform h, isoform j, isoform k,
FT                   isoform l, isoform m and isoform n)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060426"
FT   VAR_SEQ         558..1190
FT                   /note="Missing (in isoform h, isoform j, isoform k, isoform
FT                   l, isoform m and isoform n)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060427"
FT   VAR_SEQ         810
FT                   /note="V -> VKAKTKLSRVSENVVPDETPKLIPLEKLK (in isoform d and
FT                   isoform p)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060428"
FT   MUTAGEN         75
FT                   /note="L->P: In ju146; increases the number of lgg-1-
FT                   containing protein aggregates in the neurites of AIY
FT                   interneurons. This is further increased in either an atg-
FT                   4.2 ola316 or atg-4.2 gk628327 mutant background. Reduces
FT                   the retrograde trafficking of autophagosomes in AIY
FT                   neurites, but increases anterograde autophagosome
FT                   trafficking and increases the number of autophagosomes
FT                   which are not trafficked. This results in an abnormal
FT                   accumulation of autophagic vacuoles in neurites."
FT                   /evidence="ECO:0000269|PubMed:30880001"
FT   MUTAGEN         765..1157
FT                   /note="Missing: In n730; increases the number of lgg-1-
FT                   containing protein aggregates in the neurites of AIY
FT                   interneurons."
FT                   /evidence="ECO:0000269|PubMed:30880001"
SQ   SEQUENCE   1190 AA;  134219 MW;  0AC346C0372882A2 CRC64;
     MACNLSPVNE MADSITSSTP SEIVYGGPGS PDEHRTMSDK VQTMASAIYR ELETMIKVHG
     EDGVKTLMPL VVNVLEALDL AYLERDEQTA ELEMLKEDNE QLQTQYEREK ALRKQTEQKY
     IEIEDTLIGQ NKELDKKIES LESIMRMLEL KAKNATDHAS RLEEREVEQK LEFDRLHERY
     NTLLRTHVDH MERTKYLMGS EKFELMQNMP LPNMQLRNKM GMAASVDASS IRGVSDLISA
     HMTQSTTMDV NLANHITNED WQDEFSSDIE PSPRDIPQSS ADALTSPITT KEPTPKREAA
     SPKQSEEEEA DETTSVDPKE NNDLLGADLT DDESDWNGLG LIPRRHRPNE MLDDDDTSDD
     GSLGMGREVE NLIKENSELL DMKNALNIVK NDLINQVDEL NSENMILRDE NLSRQMVSEK
     MQEQITKHEE EIKTLKQKLM EKENEQEEDD VPMAMRKRFT RSEMQRVLMD RNAYKEKLME
     LEESIKWTEM QRAKKMQQQQ QNVNQKKSGG IWEFFSSLLG DSVTPPASSR GNRASSSRGK
     MTRSVEYIDP DMISERRAAE RREQYKLVRE HVKKEDGRIE AYGWSLPNVE AEVSSVPIPV
     CCRPLLDNEP SLKIWCATGV VLRGGRDERG QWIVGDPIYF APASMKKTKT SNHRPELEDE
     IKRARNLDAR ESELDEWQSS SLVWVVSSNQ GKSLIAVLDA NNPNNIIETF PACDSHLLCI
     QAVSGVMEGE PEMNEEQSKK YLSGGGKIKD LPEGLDGTDL GACEWVELRK MEDSEDGVPT
     YCSNDMKPSP KRTRDFSISE VAPVDSSAPV KEDPLPPPAN RPGGRAALPP HIRDAMSKYD
     GVSGQMSGAL PTVWMGGQNQ YIYIHSAVTA WKQCLRRIKM PDAVLSIVHY KSRIFAALAN
     GTIAIFHRNK HGEWSDEGYH SLRVGSATSS VRSLCLVSTN IWATYKNCVV VLDAESLQIV
     KVFAAHPRKD SQVRNMQWVG AGVWLSIRLD STLRLYHAHT YEHLQDVDIE PYVTKMLGTS
     KLDFSYMRTT ALLVSNRRLW IGTGTGVIIS VPFSGQLEKK IETKDSKRPA GPGGLVRVYG
     ATSENATNDE KTNDDFIPYC NLAHAQLSFH GHKDSVKFFL GVPGASKNGE DESAEVTLRR
     MLIMSGGDGY IDFRIGEENE PELTGQSIRP RDMSHLIIWE VDAELPILSK
 
 
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