JJJ1_CANGA
ID JJJ1_CANGA Reviewed; 623 AA.
AC Q6FP17;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Negative regulator of PDR1-mediated fluconazole resistance JJJ1 {ECO:0000303|PubMed:29507891};
DE AltName: Full=J protein JJJ1 {ECO:0000303|PubMed:29507891};
GN Name=JJJ1 {ECO:0000303|PubMed:29507891}; OrderedLocusNames=CAGL0J07370g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=29507891; DOI=10.1128/msphere.00466-17;
RA Whaley S.G., Caudle K.E., Simonicova L., Zhang Q., Moye-Rowley W.S.,
RA Rogers P.D.;
RT "Jjj1 is a negative regulator of Pdr1-mediated fluconazole resistance in
RT Candida glabrata.";
RL MSphere 3:0-0(2018).
CC -!- FUNCTION: Acts as a negative regulator of fluconazole resistance,
CC primarily through down-regulation of the ABC transporter gene CDR1 via
CC inactivation of the PDR1 transcriptional pathway.
CC {ECO:0000269|PubMed:29507891}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Leads to fluconazole resistance and activates
CC genes of the PDR1 regulon including CDR1, YBT1, YOR1, RSB1, RTA1, PDH1,
CC and NCE103; as well as PDR1-independent adhesion-related genes such as
CC EPA1, EPA2, and EPA3. {ECO:0000269|PubMed:29507891}.
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DR EMBL; CR380956; CAG60978.1; -; Genomic_DNA.
DR RefSeq; XP_448027.1; XM_448027.1.
DR AlphaFoldDB; Q6FP17; -.
DR SMR; Q6FP17; -.
DR STRING; 5478.XP_448027.1; -.
DR EnsemblFungi; CAG60978; CAG60978; CAGL0J07370g.
DR GeneID; 2889590; -.
DR KEGG; cgr:CAGL0J07370g; -.
DR CGD; CAL0129917; JJJ1.
DR VEuPathDB; FungiDB:CAGL0J07370g; -.
DR eggNOG; KOG0717; Eukaryota.
DR HOGENOM; CLU_009539_2_1_1; -.
DR InParanoid; Q6FP17; -.
DR OMA; SEYSENC; -.
DR Proteomes; UP000002428; Chromosome J.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR GO; GO:0001671; F:ATPase activator activity; IEA:EnsemblFungi.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:EnsemblFungi.
DR GO; GO:2001024; P:negative regulation of response to drug; IMP:CGD.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:EnsemblFungi.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0006364; P:rRNA processing; IEA:EnsemblFungi.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR022755; Znf_C2H2_jaz.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF12171; zf-C2H2_jaz; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..623
FT /note="Negative regulator of PDR1-mediated fluconazole
FT resistance JJJ1"
FT /id="PRO_0000445276"
FT DOMAIN 4..70
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT ZN_FING 363..387
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 448..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 72885 MW; 0C5EE5B92B5C3C25 CRC64;
MKTCYYDLLE VRSDASDLDL KKAYRRKALQ YHPDKNPDNV EEATTIFAEI RAAYEVLSDP
QERAWYDSHK EQILSDTPLN PNDEDDDYVV DSTVTGVTTE ELMMFFNSSL YTSIDNSPAG
FYQIAGKVFA KIAKDEVSWG LRLGLDGYKN YKDMEFEEHI NSRGYILACD SSKANLSNLL
FPIFGYSSTS YEELKLFYTK WSSFNTLKSF TWKDEYMYSR NYDRRTKREI NKRNEKARAK
AKEEYIKTVK RYVNFIKKLD QRMKEGAKKA AEKRLADERL RKENEMKLRK ERLNNEQGAQ
FHLQSWQTID QENWKELEKQ YEKEFEKRNV DKDDELIGHE FTKNQFQTNN NSQHEDVDEI
IIYDCFICKK SFKSEKQLEN HIKTKLHKRN LDRVQKEMKK DSMALGLDEL SDYNDFDSAE
SETEKLYSGM DLNDIDAELK KIEEQLAQSS VTDSEDFTDD NNDTEDQNSL VDKLSNTNYD
IEIDDEINDD TNEEVQISGA DNSETQNAEQ DHDSNGDSEE EKEDELTRIL RELEESKTSR
SNFSDSDEEW SNKKKTKAKK KKNKANTPDK QPVTANKNDA KEVCGECRAE FESRNQLFSH
IQTEGHVSPL SKVKKGKRSK KNK
