JKIP1_RAT
ID JKIP1_RAT Reviewed; 626 AA.
AC Q3SWS9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Janus kinase and microtubule-interacting protein 1;
DE AltName: Full=Multiple alpha helices and RNA-linker protein 1;
DE Short=Marlin-1;
GN Name=Jakmip1; Synonyms=Marlin1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP INTERACTION WITH GABBR1, TOPOLOGY, TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RX PubMed=14718537; DOI=10.1074/jbc.m311737200;
RA Couve A., Restituito S., Brandon J.M., Charles K.J., Bawagan H.,
RA Freeman K.B., Pangalos M.N., Calver A.R., Moss S.J.;
RT "Marlin-1, a novel RNA-binding protein associates with GABA receptors.";
RL J. Biol. Chem. 279:13934-13943(2004).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=17532644; DOI=10.1016/j.mcn.2007.04.008;
RA Vidal R.L., Ramirez O.A., Sandoval L., Koenig-Robert R., Haertel S.,
RA Couve A.;
RT "Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton
RT and regulate receptor transport.";
RL Mol. Cell. Neurosci. 35:501-512(2007).
RN [4]
RP SUBCELLULAR LOCATION, INTERACTION WITH GABABR1, AND TISSUE SPECIFICITY.
RX PubMed=17668444; DOI=10.1002/jcb.21456;
RA Vidal R.L., Ramirez A., Castro M., Concha I.I., Couve A.;
RT "Marlin-1 is expressed in testis and associates to the cytoskeleton and
RT GABA(B) receptors.";
RL J. Cell. Biochem. 103:886-895(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Associates with microtubules and may play a role in the
CC microtubule-dependent transport of the GABA-B receptor. May play a role
CC in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
CC {ECO:0000269|PubMed:17532644}.
CC -!- SUBUNIT: Homodimer (By similarity). Interacts with JAK1 and TYK2 (By
CC similarity). Forms a complex with GABBR1 and KIF5B/kinesin-1.
CC {ECO:0000250, ECO:0000269|PubMed:14718537,
CC ECO:0000269|PubMed:17668444}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Membrane; Peripheral
CC membrane protein. Note=Colocalizes with the microtubule network.
CC Localizes to the cell body and neurites of hippocampal neurons where it
CC accumulates in granules. Localizes to the tail and to a lower extent to
CC the head of sperm cells.
CC -!- TISSUE SPECIFICITY: Specifically expressed in brain and testis by
CC spermatogonia, spermatocytes, spermatozoa and Sertoli cells (at protein
CC level). {ECO:0000269|PubMed:14718537, ECO:0000269|PubMed:17668444}.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the JAKMIP family. {ECO:0000305}.
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DR EMBL; BC104677; AAI04678.1; -; mRNA.
DR EMBL; BC104718; AAI04719.1; -; mRNA.
DR RefSeq; NP_001029066.1; NM_001033894.1.
DR AlphaFoldDB; Q3SWS9; -.
DR SMR; Q3SWS9; -.
DR STRING; 10116.ENSRNOP00000006771; -.
DR iPTMnet; Q3SWS9; -.
DR PhosphoSitePlus; Q3SWS9; -.
DR jPOST; Q3SWS9; -.
DR PaxDb; Q3SWS9; -.
DR PRIDE; Q3SWS9; -.
DR GeneID; 305434; -.
DR KEGG; rno:305434; -.
DR CTD; 152789; -.
DR RGD; 1562401; Jakmip1.
DR VEuPathDB; HostDB:ENSRNOG00000004998; -.
DR eggNOG; ENOG502QS6X; Eukaryota.
DR HOGENOM; CLU_020294_2_0_1; -.
DR InParanoid; Q3SWS9; -.
DR OMA; IEEKHSF; -.
DR OrthoDB; 727914at2759; -.
DR PhylomeDB; Q3SWS9; -.
DR TreeFam; TF331900; -.
DR PRO; PR:Q3SWS9; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000004998; Expressed in frontal cortex and 15 other tissues.
DR Genevisible; Q3SWS9; RN.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0019898; C:extrinsic component of membrane; ISO:RGD.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:MGI.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISO:RGD.
DR GO; GO:0050811; F:GABA receptor binding; ISO:RGD.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0019894; F:kinesin binding; ISO:RGD.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; ISO:RGD.
DR GO; GO:0050890; P:cognition; ISO:RGD.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR024836; JAKMIP.
DR InterPro; IPR031994; JAKMIP_C.
DR PANTHER; PTHR18935; PTHR18935; 1.
DR Pfam; PF16034; JAKMIP_CC3; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Microtubule;
KW Phosphoprotein; Protein transport; Reference proteome; Transport.
FT CHAIN 1..626
FT /note="Janus kinase and microtubule-interacting protein 1"
FT /id="PRO_0000323010"
FT REGION 1..365
FT /note="Mediates association with microtubules"
FT /evidence="ECO:0000250"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..626
FT /note="Mediates interaction with TYK2 and GABBR1"
FT /evidence="ECO:0000250"
FT REGION 452..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..255
FT /evidence="ECO:0000255"
FT COILED 284..413
FT /evidence="ECO:0000255"
FT COILED 490..604
FT /evidence="ECO:0000255"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 382
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96N16"
FT MOD_RES 470
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96N16"
SQ SEQUENCE 626 AA; 73107 MW; 1EF2D3C42DFA552B CRC64;
MSKKGRSKGE KPETETDSVQ MANEELRAKL TNIQIEFQQE KSKVGKLRER LQEAKLEREQ
EQRRHTAYIS ELKAKLHEEK TKELQALREA LIRQHEQEAA RTAKIKEGEL QRLQATLNVL
RDGAADKVKT ALLADAREEA RRTFDGERQR LQQEILELKA ARKQAEEALS NCMQADKAKA
ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKERVIL ALEKELGVQA GQTQRLLLQK
EALDEQLVQV KEAERHHSSP KRELPPGIGD MAELMGGQDQ HMDERDVRRF QLKIAELNSV
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLHSI QRMEEKLKSL
TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL
RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDETTT
REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE
KLLVEKGQDA AWVEEKQVLM RTNQDLLEKI YRLEMEENQL KSEMQDAKDQ NELLEFRVLE
LEVRDSICCK LSNGADILFE PKLKFV
