JKIP3_MOUSE
ID JKIP3_MOUSE Reviewed; 844 AA.
AC Q5DTN8; Q0VDR4; Q0VDR5; Q9CU41;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Janus kinase and microtubule-interacting protein 3;
DE AltName: Full=Neuroendocrine long coiled-coil protein 2;
GN Name=Jakmip3; Synonyms=Kiaa4091, Necc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-437 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=17572408; DOI=10.1016/j.febslet.2007.06.002;
RA Cruz-Garcia D., Vazquez-Martinez R., Peinado J.R., Anouar Y., Tonon M.C.,
RA Vaudry H., Castano J.P., Malagon M.M.;
RT "Identification and characterization of two novel (neuro)endocrine long
RT coiled-coil proteins.";
RL FEBS Lett. 581:3149-3156(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:17572408}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5DTN8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5DTN8-2; Sequence=VSP_032000, VSP_032002, VSP_032003;
CC Name=3;
CC IsoId=Q5DTN8-3; Sequence=VSP_032001, VSP_032002, VSP_032003;
CC -!- MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the JAKMIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90506.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK220482; BAD90506.1; ALT_INIT; mRNA.
DR EMBL; BC119557; AAI19558.1; -; mRNA.
DR EMBL; BC119558; AAI19559.1; -; mRNA.
DR EMBL; AK018189; BAB31115.2; -; mRNA.
DR RefSeq; NP_082984.1; NM_028708.2. [Q5DTN8-1]
DR AlphaFoldDB; Q5DTN8; -.
DR SMR; Q5DTN8; -.
DR BioGRID; 216415; 2.
DR IntAct; Q5DTN8; 1.
DR STRING; 10090.ENSMUSP00000130207; -.
DR iPTMnet; Q5DTN8; -.
DR PhosphoSitePlus; Q5DTN8; -.
DR PaxDb; Q5DTN8; -.
DR PRIDE; Q5DTN8; -.
DR ProteomicsDB; 269363; -. [Q5DTN8-1]
DR ProteomicsDB; 269364; -. [Q5DTN8-2]
DR ProteomicsDB; 269365; -. [Q5DTN8-3]
DR Antibodypedia; 19297; 25 antibodies from 11 providers.
DR Ensembl; ENSMUST00000166163; ENSMUSP00000130207; ENSMUSG00000056856. [Q5DTN8-1]
DR GeneID; 74004; -.
DR KEGG; mmu:74004; -.
DR UCSC; uc029wpf.2; mouse. [Q5DTN8-1]
DR UCSC; uc033jcq.1; mouse. [Q5DTN8-3]
DR UCSC; uc033jcr.1; mouse. [Q5DTN8-2]
DR CTD; 282973; -.
DR MGI; MGI:1921254; Jakmip3.
DR VEuPathDB; HostDB:ENSMUSG00000056856; -.
DR eggNOG; ENOG502QRTR; Eukaryota.
DR GeneTree; ENSGT00940000153713; -.
DR InParanoid; Q5DTN8; -.
DR OMA; RQVKEHE; -.
DR OrthoDB; 727914at2759; -.
DR PhylomeDB; Q5DTN8; -.
DR BioGRID-ORCS; 74004; 1 hit in 20 CRISPR screens.
DR ChiTaRS; Jakmip3; mouse.
DR PRO; PR:Q5DTN8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q5DTN8; protein.
DR Bgee; ENSMUSG00000056856; Expressed in hypothalamus and 31 other tissues.
DR ExpressionAtlas; Q5DTN8; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR InterPro; IPR024836; JAKMIP.
DR InterPro; IPR031994; JAKMIP_C.
DR PANTHER; PTHR18935; PTHR18935; 1.
DR Pfam; PF16034; JAKMIP_CC3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Golgi apparatus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..844
FT /note="Janus kinase and microtubule-interacting protein 3"
FT /id="PRO_0000323012"
FT REGION 249..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..259
FT /evidence="ECO:0000255"
FT COILED 289..421
FT /evidence="ECO:0000255"
FT COILED 493..621
FT /evidence="ECO:0000255"
FT COILED 688..833
FT /evidence="ECO:0000255"
FT COMPBIAS 249..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 212..285
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032000"
FT VAR_SEQ 212..283
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032001"
FT VAR_SEQ 535
FT /note="T -> V (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032002"
FT VAR_SEQ 536..844
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032003"
FT CONFLICT 229
FT /note="L -> F (in Ref. 3; BAB31115)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 844 AA; 98715 MW; 39541A48498106C4 CRC64;
MSKKGAGSRA KGDKAETLAA LQAANEELRA KLTDIQIELQ QEKSKVSKVE REKSQELKQV
REHEQRKHAV LVTELKTKLH EEKMKELQAV REALLRQHEA ELLRVIKIKD NENQRLQALL
NTLRDGAPDK VKTVLLCEAK EEAKKGFEVE KVKMQQEISE LKGAKKQVEE ALTMVIQADK
IKAAEIRSVY HLHQEEITRI KKECEREIRR LMEEIRFKDR AVFVLERELG VQAGHAQRLQ
LQKEALDEQL SQAKEAERHP GSPRRELPYA SGAGDASDHS GSPEQQLDEK DARRFQLKIA
ELSAIIRKLE DRNALLSEER NELLKRLREA ESQYKPLLDK NKRLTRKNED LSHTLRRIES
KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREIDFL KLQIVEQQNL IDELSKTLET
AGYVKSVLER DKLLRYRKQR KKMAKLPKPV VVETFFGYDE EASLESDGSS ISYQTDRTDQ
TPCTPEDDLE EGMAKEETEL RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ
AEIQRAQTRV EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLKHEVQD
AKDQNELLEF RILELEERER KSPAINFHHT PFVDGKSPLQ VYCEAEGVTD ILVTELMKKL
DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQRIEETESA LQRKMVDLES EKELFSKQKG
YLDEELDYRK QALDQAHKHI LELEAMLYDA LQQEAGAKVA ELLSEEEREK LKVAVEQWKR
QVMSELRERD AQILRERMEL LQIAQQRIKE LEERIETQKR QIKELEEKFL FLFLFFSLAF
ILWS
