ID   JMJ2_SCHPO              Reviewed;         715 AA.
AC   Q9US53;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Jumonji/ARID domain-containing protein 2;
GN   Name=jmj2; ORFNames=SPAC1002.05c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
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DR   EMBL; CU329670; CAB65605.1; -; Genomic_DNA.
DR   RefSeq; NP_593492.1; NM_001018926.2.
DR   AlphaFoldDB; Q9US53; -.
DR   SMR; Q9US53; -.
DR   BioGRID; 279703; 55.
DR   STRING; 4896.SPAC1002.05c.1; -.
DR   PaxDb; Q9US53; -.
DR   EnsemblFungi; SPAC1002.05c.1; SPAC1002.05c.1:pep; SPAC1002.05c.
DR   GeneID; 2543275; -.
DR   KEGG; spo:SPAC1002.05c; -.
DR   PomBase; SPAC1002.05c; jmj2.
DR   VEuPathDB; FungiDB:SPAC1002.05c; -.
DR   eggNOG; KOG1246; Eukaryota.
DR   HOGENOM; CLU_000991_4_1_1; -.
DR   InParanoid; Q9US53; -.
DR   OMA; ANYQHEG; -.
DR   PhylomeDB; Q9US53; -.
DR   PRO; PR:Q9US53; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000785; C:chromatin; ISM:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0003677; F:DNA binding; ISM:PomBase.
DR   GO; GO:0032452; F:histone demethylase activity; IBA:GO_Central.
DR   GO; GO:0051864; F:histone H3-methyl-lysine-36 demethylase activity; ISO:PomBase.
DR   GO; GO:0032453; F:histone H3-methyl-lysine-4 demethylase activity; IDA:PomBase.
DR   GO; GO:0034647; F:histone H3-tri/di/monomethyl-lysine-4 demethylase activity; IDA:PomBase.
DR   GO; GO:0008270; F:zinc ion binding; ISM:PomBase.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:PomBase.
DR   Gene3D; 1.10.150.60; -; 1.
DR   InterPro; IPR001606; ARID_dom.
DR   InterPro; IPR036431; ARID_dom_sf.
DR   InterPro; IPR003347; JmjC_dom.
DR   InterPro; IPR003349; JmjN.
DR   InterPro; IPR004198; Znf_C5HC2.
DR   Pfam; PF02373; JmjC; 1.
DR   Pfam; PF02375; JmjN; 1.
DR   Pfam; PF02928; zf-C5HC2; 1.
DR   SMART; SM00501; BRIGHT; 1.
DR   SMART; SM00558; JmjC; 1.
DR   SMART; SM00545; JmjN; 1.
DR   SUPFAM; SSF46774; SSF46774; 1.
DR   PROSITE; PS51011; ARID; 1.
DR   PROSITE; PS51184; JMJC; 1.
DR   PROSITE; PS51183; JMJN; 1.
PE   4: Predicted;
KW   Iron; Metal-binding; Reference proteome.
FT   CHAIN           1..715
FT                   /note="Jumonji/ARID domain-containing protein 2"
FT                   /id="PRO_0000200598"
FT   DOMAIN          60..101
FT                   /note="JmjN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00537"
FT   DOMAIN          125..217
FT                   /note="ARID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT   DOMAIN          422..588
FT                   /note="JmjC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT   REGION          21..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         468
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT   BINDING         470
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT   BINDING         556
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
SQ   SEQUENCE   715 AA;  82880 MW;  84CA5DEDB3B8FC6F CRC64;
     MSKSTFHQTS PSFVQYTHAT DKLKPAPHGM NTRGNNLSSM SKNTGQRKQR SKSIHGLPVA
     PVFYPDKEEF QDSIGYINKI APIGEKYGII KIVPPAGWNP PMQLDMNKFS FRTRRQDLHM
     MDLRFREIVS YDERVYRFFC NLGMELPESF FISNTSIDLY SLMRCIDSHA SLSEKELKVH
     VWKRILRELS IPFTNASLKE ASDLYLRYIF PFEDFVRKYQ TSEDQCFETD LFPKFFTKDE
     HSNISIKDQK TSKQFNPETN ESVGILQNQE SKRNEQIKQQ YMPADNFGSN DNHSHNKKRR
     LSSLSTNNNH LCDNCHKPVN CEVEDTCKEA YCTKCIINPY EFGFETGNYY TLSNFEKYCD
     NFKKNYFSKF KDSEITEDIV EKEYWKLVKD NNTSLEVEYG ADLSTLDQGS AFPSLAKNPV
     NPYSKDTWNL NVIASTNGSL LSYIDNPVSG ITCPWLYVGM CFSTFCWHVE DNYTYSVNYQ
     HYGDTKLWYG IPGDQAERFE RAALDIAPDL VKKQKDLLYQ LATMINPDEL QKRGVDVYFI
     DQGPNEFVIT FPKSFHAGIN HGFNINEAVN FAPKDWLLNG FSLNGVLKYQ SLLKPPVLSH
     DMLVYNLATN PASEISVSEL RPWVHEAVKR ELGIRIMIRG RYDLKEILYR ELMEDAENWQ
     CQHCKAFSYF SQVACSCKSI TVCPLHIEYL CKCDLSNKTL RLKVDDNELQ KLLSY