JMJ4_SCHPO
ID JMJ4_SCHPO Reviewed; 473 AA.
AC O94606;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=JmjC domain-containing protein 4;
DE AltName: Full=Jumonji domain-containing protein 4;
DE AltName: Full=Meiotically up-regulated gene 149 protein;
GN Name=jmj4; Synonyms=mug149; ORFNames=SPCC622.19;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA21875.2; -; Genomic_DNA.
DR PIR; T41500; T41500.
DR RefSeq; NP_588191.1; NM_001023181.2.
DR AlphaFoldDB; O94606; -.
DR BioGRID; 275989; 39.
DR STRING; 4896.SPCC622.19.1; -.
DR iPTMnet; O94606; -.
DR MaxQB; O94606; -.
DR PaxDb; O94606; -.
DR EnsemblFungi; SPCC622.19.1; SPCC622.19.1:pep; SPCC622.19.
DR GeneID; 2539424; -.
DR KEGG; spo:SPCC622.19; -.
DR PomBase; SPCC622.19; jmj4.
DR VEuPathDB; FungiDB:SPCC622.19; -.
DR eggNOG; KOG2508; Eukaryota.
DR HOGENOM; CLU_017405_0_0_1; -.
DR InParanoid; O94606; -.
DR OMA; PASWWHE; -.
DR PhylomeDB; O94606; -.
DR PRO; PR:O94606; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000785; C:chromatin; ISM:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; IBA:GO_Central.
DR GO; GO:0032452; F:histone demethylase activity; ISM:PomBase.
DR GO; GO:0106155; F:peptidyl-lysine 3-dioxygenase activity; ISS:PomBase.
DR GO; GO:0006338; P:chromatin remodeling; ISM:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR003347; JmjC_dom.
DR Pfam; PF13621; Cupin_8; 1.
DR SMART; SM00558; JmjC; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 1: Evidence at protein level;
KW Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..473
FT /note="JmjC domain-containing protein 4"
FT /id="PRO_0000300500"
FT DOMAIN 140..433
FT /note="JmjC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT REGION 452..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 52741 MW; B3ADD83C5A68E7E5 CRC64;
MSELSTYKGY SPKHGDKVPV LQNLNDLTPK DFYDKFIATR TPVIIKSSLP ESDWKGYLWQ
QQDYLLSKIG DIVCKVEPID PVSGTFGQGM SRNEMSIKEF FQKLKNGERL YLTTQYDESN
EVLDGDDEVS LLVKSLCPHP TDGLLTDFSI TPALMGNLVP QQCNLWIGKS ENGTSSGLHH
DFHDNIYAVI SGYKRFVIIS PDHANQLKLS GKISKIHPNG LISYEGEDCP QRSDGLTELD
AAIAKTQFLE KKIGSLKELA VPQESIELLE AEYENEMDRV LQMQIGGPEE DWNDLEEGDA
ASLLDGSVGG DPESDILLNE GNDIEATSLQ DTKPELPDHF TKVSVNGLHK FMGFDDAKNV
DVDKDELSAL AGTVPLVVDL EPGDMLYLPA SWFHEVTSSS ASSGGSDVHI AFNYWFHPPD
NLEDFDHPYL DRNIWQAKRH LVGEAIDQLY ATNKKNEKRP AEDDSPSQKK TCQ
