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JMJD4_DROME
ID   JMJD4_DROME             Reviewed;         425 AA.
AC   Q9VJ97;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=2-oxoglutarate and iron-dependent oxygenase JMJD4 homolog {ECO:0000250|UniProtKB:Q9H9V9};
DE            EC=1.14.11.-;
DE   AltName: Full=JmjC domain-containing protein 4 homolog;
DE   AltName: Full=Jumonji domain-containing protein 4 homolog;
DE   AltName: Full=Lysyl-hydroxylase JMJD4 homolog {ECO:0000250|UniProtKB:Q9H9V9};
GN   ORFNames=CG7200;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-
CC         [protein] + CO2 + succinate; Xref=Rhea:RHEA:57156, Rhea:RHEA-
CC         COMP:9752, Rhea:RHEA-COMP:15084, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:141495; Evidence={ECO:0000305};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000250|UniProtKB:Q9H9V9};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H9V9}.
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DR   EMBL; AE014134; AAF53656.1; -; Genomic_DNA.
DR   EMBL; AY051684; AAK93108.1; -; mRNA.
DR   RefSeq; NP_001286031.1; NM_001299102.1.
DR   RefSeq; NP_609870.1; NM_136026.4.
DR   AlphaFoldDB; Q9VJ97; -.
DR   SMR; Q9VJ97; -.
DR   BioGRID; 61085; 5.
DR   IntAct; Q9VJ97; 1.
DR   STRING; 7227.FBpp0080615; -.
DR   PaxDb; Q9VJ97; -.
DR   DNASU; 35089; -.
DR   EnsemblMetazoa; FBtr0081062; FBpp0080615; FBgn0032671.
DR   EnsemblMetazoa; FBtr0343823; FBpp0310373; FBgn0032671.
DR   GeneID; 35089; -.
DR   KEGG; dme:Dmel_CG7200; -.
DR   UCSC; CG7200-RA; d. melanogaster.
DR   CTD; 65094; -.
DR   FlyBase; FBgn0032671; CG7200.
DR   VEuPathDB; VectorBase:FBgn0032671; -.
DR   eggNOG; KOG2131; Eukaryota.
DR   HOGENOM; CLU_016785_2_2_1; -.
DR   InParanoid; Q9VJ97; -.
DR   OMA; MFSRRFT; -.
DR   OrthoDB; 609279at2759; -.
DR   PhylomeDB; Q9VJ97; -.
DR   BioGRID-ORCS; 35089; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; CG7200; fly.
DR   GenomeRNAi; 35089; -.
DR   PRO; PR:Q9VJ97; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0032671; Expressed in embryonic/larval hemocyte (Drosophila) and 23 other tissues.
DR   ExpressionAtlas; Q9VJ97; baseline and differential.
DR   Genevisible; Q9VJ97; DM.
DR   GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0106156; F:peptidyl-lysine 4-dioxygenase activity; IEA:RHEA.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0010629; P:negative regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0045905; P:positive regulation of translational termination; ISS:UniProtKB.
DR   GO; GO:0018126; P:protein hydroxylation; ISS:UniProtKB.
DR   InterPro; IPR003347; JmjC_dom.
DR   Pfam; PF02373; JmjC; 1.
DR   SMART; SM00558; JmjC; 1.
DR   PROSITE; PS51184; JMJC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..425
FT                   /note="2-oxoglutarate and iron-dependent oxygenase JMJD4
FT                   homolog"
FT                   /id="PRO_0000291963"
FT   DOMAIN          165..316
FT                   /note="JmjC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT   BINDING         212
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NYC1"
FT   BINDING         214
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NYC1"
FT   BINDING         284
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NYC1"
SQ   SEQUENCE   425 AA;  49169 MW;  AEE20D162CEFD758 CRC64;
     MASEERDGDV LLQLHPEEVV ETDPQLPEEI ERCSGLDYND FFWRYMHKNI PVIIANVSND
     WECQNWTVGQ SSPESRDLNS NPSASSINFD YLKTKISDGP VPVANCNSSY FNSHTKLELN
     FHDYLAKWRS SIESQSSAAW TSAEVNSNVA PASGDNLYLK DWHLAAQMPG YNFYKVPKYF
     ASDWLNEQLI QQGKDDYRFV YMGPKNSWTS YHADVFGSFS WSTNIVGLKK WLIMPPGEEL
     KLNDRLGNLP FSIDEKMLDE HNVRYYTINQ RANEAVFVPS GWFHQVWNLT DTISVNHNWF
     NGCNISMVWQ NLKNNLKAVC NEISDCQQMD NFEAHCQTML RASFGINYLD FIELLEFIAA
     RRLAEGTVAT KFLLFDSYTM NDYHVQYDLE CLWKITRTLT EDPTIQCSPL QLEDRCQGLL
     ARLEF
 
 
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