JMJD8_HUMAN
ID JMJD8_HUMAN Reviewed; 264 AA.
AC Q96S16; B2RNS7; D3DU58; Q4PKE3; Q4VBY1; Q6GMW5; Q71RB8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=JmjC domain-containing protein 8 {ECO:0000305};
DE AltName: Full=Jumonji domain-containing protein 8;
DE Flags: Precursor;
GN Name=JMJD8 {ECO:0000312|HGNC:HGNC:14148};
GN Synonyms=C16orf20 {ECO:0000312|HGNC:HGNC:14148}; ORFNames=PP14397;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M.,
RA Wen S., Lin L., Yang S.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP INTERACTION WITH PKM, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=27199445; DOI=10.1161/atvbaha.116.307695;
RA Boeckel J.N., Derlet A., Glaser S.F., Luczak A., Lucas T., Heumueller A.W.,
RA Krueger M., Zehendner C.M., Kaluza D., Doddaballapur A., Ohtani K.,
RA Treguer K., Dimmeler S.;
RT "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by
RT Interacting With Pyruvate Kinase M2 in Endothelial Cells.";
RL Arterioscler. Thromb. Vasc. Biol. 36:1425-1433(2016).
RN [8]
RP FUNCTION.
RX PubMed=27671354; DOI=10.1038/srep34125;
RA Yeo K.S., Tan M.C., Wong W.Y., Loh S.W., Lam Y.L., Tan C.L., Lim Y.Y.,
RA Ea C.K.;
RT "JMJD8 is a positive regulator of TNF-induced NF-kappaB signaling.";
RL Sci. Rep. 6:34125-34125(2016).
RN [9]
RP GLYCOSYLATION, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=29133832; DOI=10.1038/s41598-017-15676-z;
RA Yeo K.S., Tan M.C., Lim Y.Y., Ea C.K.;
RT "JMJD8 is a novel endoplasmic reticulum protein with a JmjC domain.";
RL Sci. Rep. 7:15407-15407(2017).
CC -!- FUNCTION: Functions as a positive regulator of TNF-induced NF-kappa-B
CC signaling (PubMed:27671354). Regulates angiogenesis and cellular
CC metabolism through interaction with PKM (PubMed:27199445).
CC {ECO:0000269|PubMed:27199445, ECO:0000269|PubMed:27671354}.
CC -!- SUBUNIT: Oligomer (PubMed:29133832). Dimer (PubMed:29133832). Interacts
CC with PKM; regulates angiogenesis and metabolism (PubMed:27199445).
CC {ECO:0000269|PubMed:27199445, ECO:0000269|PubMed:29133832}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000269|PubMed:29133832}. Cytoplasm {ECO:0000269|PubMed:27199445}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96S16-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96S16-2; Sequence=VSP_034849;
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:29133832}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH73785.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI37101.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI37102.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAK61243.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW85754.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW85755.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF370420; AAQ15256.1; -; mRNA.
DR EMBL; DQ074695; AAY82251.1; -; mRNA.
DR EMBL; AE006464; AAK61243.1; ALT_INIT; Genomic_DNA.
DR EMBL; Z92544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85754.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471112; EAW85755.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC073785; AAH73785.1; ALT_INIT; mRNA.
DR EMBL; BC094850; AAH94850.1; -; mRNA.
DR EMBL; BC137100; AAI37101.1; ALT_INIT; mRNA.
DR EMBL; BC137101; AAI37102.1; ALT_INIT; mRNA.
DR CCDS; CCDS45369.1; -. [Q96S16-1]
DR RefSeq; NP_001005920.2; NM_001005920.2. [Q96S16-1]
DR RefSeq; NP_001310847.1; NM_001323918.1.
DR RefSeq; NP_001310848.1; NM_001323919.1.
DR RefSeq; NP_001310851.1; NM_001323922.1.
DR AlphaFoldDB; Q96S16; -.
DR SMR; Q96S16; -.
DR BioGRID; 130831; 52.
DR IntAct; Q96S16; 11.
DR STRING; 9606.ENSP00000399475; -.
DR GlyGen; Q96S16; 3 sites.
DR iPTMnet; Q96S16; -.
DR PhosphoSitePlus; Q96S16; -.
DR BioMuta; JMJD8; -.
DR DMDM; 74717267; -.
DR EPD; Q96S16; -.
DR MassIVE; Q96S16; -.
DR PaxDb; Q96S16; -.
DR PeptideAtlas; Q96S16; -.
DR PRIDE; Q96S16; -.
DR ProteomicsDB; 78054; -. [Q96S16-1]
DR ProteomicsDB; 78055; -. [Q96S16-2]
DR Antibodypedia; 22813; 102 antibodies from 22 providers.
DR DNASU; 339123; -.
DR Ensembl; ENST00000562824.5; ENSP00000454358.1; ENSG00000161999.13. [Q96S16-2]
DR Ensembl; ENST00000609261.6; ENSP00000477481.1; ENSG00000161999.13. [Q96S16-1]
DR GeneID; 339123; -.
DR KEGG; hsa:339123; -.
DR MANE-Select; ENST00000609261.6; ENSP00000477481.1; NM_001005920.4; NP_001005920.3.
DR UCSC; uc002ciw.2; human. [Q96S16-1]
DR CTD; 339123; -.
DR DisGeNET; 339123; -.
DR GeneCards; JMJD8; -.
DR HGNC; HGNC:14148; JMJD8.
DR HPA; ENSG00000161999; Low tissue specificity.
DR MalaCards; JMJD8; -.
DR neXtProt; NX_Q96S16; -.
DR OpenTargets; ENSG00000161999; -.
DR PharmGKB; PA162392531; -.
DR VEuPathDB; HostDB:ENSG00000161999; -.
DR eggNOG; KOG2131; Eukaryota.
DR GeneTree; ENSGT00390000015438; -.
DR InParanoid; Q96S16; -.
DR OMA; KCNIERH; -.
DR OrthoDB; 1029368at2759; -.
DR PhylomeDB; Q96S16; -.
DR TreeFam; TF313408; -.
DR PathwayCommons; Q96S16; -.
DR SignaLink; Q96S16; -.
DR BioGRID-ORCS; 339123; 21 hits in 1080 CRISPR screens.
DR ChiTaRS; JMJD8; human.
DR GenomeRNAi; 339123; -.
DR Pharos; Q96S16; Tbio.
DR PRO; PR:Q96S16; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96S16; protein.
DR Bgee; ENSG00000161999; Expressed in apex of heart and 159 other tissues.
DR ExpressionAtlas; Q96S16; baseline and differential.
DR Genevisible; Q96S16; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
DR GO; GO:1903672; P:positive regulation of sprouting angiogenesis; IMP:UniProtKB.
DR GO; GO:0006110; P:regulation of glycolytic process; IMP:UniProtKB.
DR GO; GO:1903302; P:regulation of pyruvate kinase activity; IMP:UniProtKB.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR003347; JmjC_dom.
DR Pfam; PF13621; Cupin_8; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Endoplasmic reticulum; Glycoprotein;
KW Reference proteome; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..264
FT /note="JmjC domain-containing protein 8"
FT /evidence="ECO:0000255"
FT /id="PRO_0000344531"
FT DOMAIN 131..264
FT /note="JmjC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 30..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_034849"
FT CONFLICT 158
FT /note="L -> P (in Ref. 2; AAY82251)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="H -> R (in Ref. 2; AAY82251)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 264 AA; 29509 MW; 764DAF7EE2977FBC CRC64;
MAPASRLLAL WALAAVALPG SGAEGDGGWR PGGPGAVAEE ERCTVERRAD LTYAEFVQQY
AFVRPVILQG LTDNSRFRAL CSRDRLLASF GDRVVRLSTA NTYSYHKVDL PFQEYVEQLL
HPQDPTSLGN DTLYFFGDNN FTEWASLFRH YSPPPFGLLG TAPAYSFGIA GAGSGVPFHW
HGPGYSEVIY GRKRWFLYPP EKTPEFHPNK TTLAWLRDTY PALPPSARPL ECTIRAGEVL
YFPDRWWHAT LNLDTSVFIS TFLG
