JMJD8_MOUSE
ID JMJD8_MOUSE Reviewed; 271 AA.
AC Q3TA59; Q3U1Q1; Q91XD9; Q9D0L5;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=JmjC domain-containing protein 8 {ECO:0000305};
DE AltName: Full=Jumonji domain-containing protein 8;
DE Flags: Precursor;
GN Name=Jmjd8 {ECO:0000312|MGI:MGI:1919356};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-271.
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INDUCTION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=27199445; DOI=10.1161/atvbaha.116.307695;
RA Boeckel J.N., Derlet A., Glaser S.F., Luczak A., Lucas T., Heumueller A.W.,
RA Krueger M., Zehendner C.M., Kaluza D., Doddaballapur A., Ohtani K.,
RA Treguer K., Dimmeler S.;
RT "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by
RT Interacting With Pyruvate Kinase M2 in Endothelial Cells.";
RL Arterioscler. Thromb. Vasc. Biol. 36:1425-1433(2016).
CC -!- FUNCTION: Functions as a positive regulator of TNF-induced NF-kappaB
CC signaling (By similarity). Regulates angiogenesis and cellular
CC metabolism through interaction with PKM (PubMed:27199445).
CC {ECO:0000250|UniProtKB:Q96S16, ECO:0000269|PubMed:27199445}.
CC -!- SUBUNIT: Oligomer. Dimer. Interacts with PKM; regulates angiogenesis
CC and metabolism. {ECO:0000250|UniProtKB:Q96S16}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000250|UniProtKB:Q96S16}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q96S16}.
CC -!- INDUCTION: Up-regulated upon endothelial differentiation.
CC {ECO:0000269|PubMed:27199445}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q96S16}.
CC -!- DISRUPTION PHENOTYPE: Homozygote knockout Jmjd8 show no obvious
CC phenotype. However, the number of capillaries in muscle tissue is
CC significantly reduced. {ECO:0000269|PubMed:27199445}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH10800.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE42811.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK011308; BAB27534.1; -; mRNA.
DR EMBL; AK148079; BAE28331.1; -; mRNA.
DR EMBL; AK155810; BAE33443.1; -; mRNA.
DR EMBL; AK172073; BAE42811.1; ALT_FRAME; mRNA.
DR EMBL; AC159277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC010800; AAH10800.1; ALT_INIT; mRNA.
DR RefSeq; NP_082377.2; NM_028101.4.
DR AlphaFoldDB; Q3TA59; -.
DR SMR; Q3TA59; -.
DR STRING; 10090.ENSMUSP00000122744; -.
DR GlyGen; Q3TA59; 3 sites.
DR PhosphoSitePlus; Q3TA59; -.
DR EPD; Q3TA59; -.
DR PaxDb; Q3TA59; -.
DR PRIDE; Q3TA59; -.
DR ProteomicsDB; 301699; -.
DR Antibodypedia; 22813; 102 antibodies from 22 providers.
DR DNASU; 72106; -.
DR Ensembl; ENSMUST00000026832; ENSMUSP00000026832; ENSMUSG00000025736.
DR GeneID; 72106; -.
DR KEGG; mmu:72106; -.
DR UCSC; uc008bce.2; mouse.
DR CTD; 339123; -.
DR MGI; MGI:1919356; Jmjd8.
DR VEuPathDB; HostDB:ENSMUSG00000025736; -.
DR eggNOG; KOG2131; Eukaryota.
DR GeneTree; ENSGT00390000015438; -.
DR InParanoid; Q3TA59; -.
DR OMA; KCNIERH; -.
DR OrthoDB; 1029368at2759; -.
DR PhylomeDB; Q3TA59; -.
DR TreeFam; TF313408; -.
DR BioGRID-ORCS; 72106; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Jmjd8; mouse.
DR PRO; PR:Q3TA59; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q3TA59; protein.
DR Bgee; ENSMUSG00000025736; Expressed in embryonic brain and 238 other tissues.
DR ExpressionAtlas; Q3TA59; baseline and differential.
DR Genevisible; Q3TA59; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
DR GO; GO:1903672; P:positive regulation of sprouting angiogenesis; ISS:UniProtKB.
DR GO; GO:0006110; P:regulation of glycolytic process; ISS:UniProtKB.
DR GO; GO:1903302; P:regulation of pyruvate kinase activity; ISS:UniProtKB.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR003347; JmjC_dom.
DR Pfam; PF13621; Cupin_8; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Endoplasmic reticulum; Glycoprotein; Reference proteome; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..271
FT /note="JmjC domain-containing protein 8"
FT /evidence="ECO:0000255"
FT /id="PRO_0000344532"
FT DOMAIN 138..271
FT /note="JmjC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 216
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 69
FT /note="F -> L (in Ref. 1; BAB27534)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 30666 MW; ECCF2223658DF49E CRC64;
MFMAAAGRRG LLLLFVLWMM VTVILPASGE GGWKQNGLGI AAAVMEEERC TVERRAHITY
SEFMQHYAFL KPVILQGLTD NSKFRALCSR ENLLASFGDN IVRLSTANTY SYQKVDLPFQ
EYVEQLLQPQ DPASLGNDTL YFFGDNNFTE WASLFQHYSP PPFRLLGTTP AYSFGIAGAG
SGVPFHWHGP GFSEVIYGRK RWFLYPPEKT PEFHPNKTTL AWLLEIYPSL ALSARPLECT
IQAGEVLYFP DRWWHATLNL DTSVFISTFL G
