ID   JSPR1_BOVIN             Reviewed;         337 AA.
AC   Q2YDF7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Junctional sarcoplasmic reticulum protein 1;
GN   Name=JSRP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in skeletal muscle excitation/contraction coupling
CC       (EC), probably acting as a regulator of the voltage-sensitive calcium
CC       channel CACNA1S (By similarity). EC is a physiological process whereby
CC       an electrical signal (depolarization of the plasma membrane) is
CC       converted into a chemical signal, a calcium gradient, by the opening of
CC       ryanodine receptor calcium release channels. May regulate CACNA1S
CC       membrane targeting and activity. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CACNA1S, CACNB1 and calsequestrin.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250}.
CC       Endoplasmic reticulum membrane {ECO:0000250}. Note=Colocalizes with
CC       ryanodine receptors at the sarcoplasmic reticulum triad membranes.
CC       {ECO:0000250}.
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DR   EMBL; BC110244; AAI10245.1; -; mRNA.
DR   RefSeq; NP_001039496.1; NM_001046031.2.
DR   AlphaFoldDB; Q2YDF7; -.
DR   STRING; 9913.ENSBTAP00000019913; -.
DR   PaxDb; Q2YDF7; -.
DR   PRIDE; Q2YDF7; -.
DR   GeneID; 509378; -.
DR   KEGG; bta:509378; -.
DR   CTD; 126306; -.
DR   eggNOG; ENOG502S4JK; Eukaryota.
DR   InParanoid; Q2YDF7; -.
DR   OrthoDB; 1387662at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003009; P:skeletal muscle contraction; ISS:UniProtKB.
DR   InterPro; IPR026178; JSRP1.
DR   PANTHER; PTHR22397; PTHR22397; 1.
DR   Pfam; PF15312; JSRP; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome;
KW   Sarcoplasmic reticulum.
FT   CHAIN           1..337
FT                   /note="Junctional sarcoplasmic reticulum protein 1"
FT                   /id="PRO_0000314024"
FT   REGION          1..84
FT                   /note="Mediates interaction with CACNA1S"
FT                   /evidence="ECO:0000250"
FT   REGION          23..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..215
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..328
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   337 AA;  36954 MW;  BD38669357C3ADA7 CRC64;
     MATRAMEELD GGLGSCQVDE DLSALADPCP SRPQEDSVRA TSRLADSSSR SHDSQERVTE
     GSPTGSVDTK PKKMEKEPVS KVTSGAGKEK LKAGATPRSP ARKKAQTASP TQPPPPPALS
     DELPWGDLTL NKCLVLASLV ALLGSAFQLC REAVARDVEA PAPVPESWAS SSSSPKGPAS
     TLPKPEAWAP SVRQPEPPSK LEERVQIPRS EEAAEKDEWE SEEAADGEHV PLAGRGPKEK
     LKKEKPRKER PGKEKPQKEE RPRKEKPRKE EKPRGAREPQ GALPRRWEAR EGGHRPWGRD
     SGAPEDRKRQ AWVSLRRPDE EDRPLGRQKR RAGKGRD