ID   JTB_BRUMA               Reviewed;         146 AA.
AC   O77049;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Protein JTB;
DE   Flags: Precursor;
GN   Name=JTB;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10321732; DOI=10.1038/sj.onc.1202510;
RA   Hatakeyama S., Osawa M., Omine M., Ishikawa F.;
RT   "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping
RT   translocation.";
RL   Oncogene 18:2085-2090(1999).
CC   -!- FUNCTION: Required for normal cytokinesis during mitosis. Plays a role
CC       in the regulation of cell proliferation. May be a component of the
CC       chromosomal passenger complex (CPC), a complex that acts as a key
CC       regulator of mitosis. The CPC complex has essential functions at the
CC       centromere in ensuring correct chromosome alignment and segregation and
CC       is required for chromatin-induced microtubule stabilization and spindle
CC       assembly (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center,
CC       centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250}. Note=Detected at the centrosome and along spindle fibers
CC       during prophase and metaphase. Detected at the midbody during telophase
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the JTB family. {ECO:0000305}.
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DR   EMBL; AB016491; BAA33734.1; -; mRNA.
DR   AlphaFoldDB; O77049; -.
DR   SMR; O77049; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR   GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0000281; P:mitotic cytokinesis; ISS:UniProtKB.
DR   GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.
DR   InterPro; IPR008657; JTB.
DR   PANTHER; PTHR13041; PTHR13041; 1.
DR   Pfam; PF05439; JTB; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Membrane;
KW   Mitochondrion; Mitosis; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..146
FT                   /note="Protein JTB"
FT                   /id="PRO_0000021534"
FT   TOPO_DOM        31..105
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   146 AA;  16487 MW;  F891A9D74FBD217C CRC64;
     MLAGARRLGL PRGGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL VEEFVVTEEC
     APCSNFQIKS TPECGSTGYM EKITCSPSKR NEFRSCRSAL MERHLFWKFE GTVVAVALVF
     ACLVIIRQRQ LDRKALEKVR KQIESI