ID   JTB_RAT                 Reviewed;         146 AA.
AC   O88823;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Protein JTB;
DE   Flags: Precursor;
GN   Name=Jtb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10321732; DOI=10.1038/sj.onc.1202510;
RA   Hatakeyama S., Osawa M., Omine M., Ishikawa F.;
RT   "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping
RT   translocation.";
RL   Oncogene 18:2085-2090(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for normal cytokinesis during mitosis. Plays a role
CC       in the regulation of cell proliferation. May be a component of the
CC       chromosomal passenger complex (CPC), a complex that acts as a key
CC       regulator of mitosis. The CPC complex has essential functions at the
CC       centromere in ensuring correct chromosome alignment and segregation and
CC       is required for chromatin-induced microtubule stabilization and spindle
CC       assembly. Increases AURKB activity. Inhibits apoptosis induced by
CC       TGFB1. Overexpression induces swelling of mitochondria and reduces
CC       mitochondrial membrane potential (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a
CC       component of the CPC at least composed of BIRC5/survivin,
CC       CDCA8/borealin, INCENP and AURKB/Aurora-B (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center,
CC       centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250}. Note=Detected at the centrosome and along spindle fibers
CC       during prophase and metaphase. Detected at the midbody during telophase
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the JTB family. {ECO:0000305}.
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DR   EMBL; AB016489; BAA33732.1; -; mRNA.
DR   EMBL; BC062090; AAH62090.1; -; mRNA.
DR   RefSeq; NP_062086.1; NM_019213.2.
DR   AlphaFoldDB; O88823; -.
DR   SMR; O88823; -.
DR   STRING; 10116.ENSRNOP00000060227; -.
DR   PaxDb; O88823; -.
DR   Ensembl; ENSRNOT00000064752; ENSRNOP00000060227; ENSRNOG00000016379.
DR   GeneID; 29439; -.
DR   KEGG; rno:29439; -.
DR   CTD; 10899; -.
DR   RGD; 2942; Jtb.
DR   eggNOG; KOG4084; Eukaryota.
DR   GeneTree; ENSGT00390000016136; -.
DR   HOGENOM; CLU_130083_1_0_1; -.
DR   InParanoid; O88823; -.
DR   OMA; GRRLCWL; -.
DR   OrthoDB; 1375062at2759; -.
DR   PhylomeDB; O88823; -.
DR   TreeFam; TF316934; -.
DR   PRO; PR:O88823; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000016379; Expressed in quadriceps femoris and 20 other tissues.
DR   Genevisible; O88823; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR   GO; GO:0008637; P:apoptotic mitochondrial changes; ISO:RGD.
DR   GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0000281; P:mitotic cytokinesis; ISS:UniProtKB.
DR   GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISO:RGD.
DR   InterPro; IPR008657; JTB.
DR   PANTHER; PTHR13041; PTHR13041; 1.
DR   Pfam; PF05439; JTB; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Membrane;
KW   Mitochondrion; Mitosis; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..146
FT                   /note="Protein JTB"
FT                   /id="PRO_0000021537"
FT   TOPO_DOM        31..105
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   146 AA;  16385 MW;  52334B38F6326848 CRC64;
     MLVGAGRRGL PRGGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL VEEFVVTEEC
     TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL LEQHLFWKFE GIVVGVALVF
     ACLVIIRQRQ LDRKALEKVR KQIESI