ID   JUN_AVIS1               Reviewed;         287 AA.
AC   P05411;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Viral jun-transforming protein;
DE            Short=v-Jun;
GN   Name=JUN;
OS   Avian sarcoma virus (strain 17).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus;
OC   unclassified Alpharetrovirus.
OX   NCBI_TaxID=11877;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3033666; DOI=10.1073/pnas.84.9.2848;
RA   Maki Y., Bos T.J., Davis C., Starbuck M., Vogt P.K.;
RT   "Avian sarcoma virus 17 carries the jun oncogene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:2848-2852(1987).
CC   -!- FUNCTION: This oncogene is the viral derivative of the AP-1
CC       transcription factor.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- MISCELLANEOUS: This protein is synthesized as a Gag-vJun chimeric
CC       protein. The sequence shown here corresponds to the Jun homolog
CC       fragment of the chimera.
CC   -!- SIMILARITY: Belongs to the bZIP family. Jun subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA42416.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M16266; AAA42416.1; ALT_INIT; Genomic_RNA.
DR   PIR; A29870; TVFVJN.
DR   PDB; 2H7H; X-ray; 2.30 A; A/B=210-271.
DR   PDBsum; 2H7H; -.
DR   BMRB; P05411; -.
DR   SMR; P05411; -.
DR   ELM; P05411; -.
DR   EvolutionaryTrace; P05411; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR015558; C_Jun/v-Jun.
DR   InterPro; IPR005643; JNK.
DR   InterPro; IPR002112; Leuzip_Jun.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   PANTHER; PTHR11462:SF8; PTHR11462:SF8; 2.
DR   Pfam; PF00170; bZIP_1; 1.
DR   Pfam; PF03957; Jun; 1.
DR   PRINTS; PR00043; LEUZIPPRJUN.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF47454; SSF47454; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Host nucleus; Oncogene; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..287
FT                   /note="Viral jun-transforming protein"
FT                   /id="PRO_0000076436"
FT   DOMAIN          208..271
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          208..235
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          236..264
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   HELIX           211..264
FT                   /evidence="ECO:0007829|PDB:2H7H"
SQ   SEQUENCE   287 AA;  31554 MW;  B24E12AF208BD6A3 CRC64;
     MSAKMEPTFY EDALNASFAP PESGGYGYNN ADILTSPDVG LLKLASPELE RLIIQSSNGL
     ITTTPTPTQF LCPKNVTDEQ EGFAEGFVRA LAELHNQNTL PSVTSAAQPV SGGMAPVSSM
     AGGGSFNTSL HSEPPVYANL SNFNPNALNS APNYNANRMG YAPQHHINPQ MPVQHPRLQA
     LKEEPQTVPE MPGETPPLFP IDMESQERIK AERKRMRNRI AASKSRKRKL ERIARLEEKV
     KTLKAQNSEL ASTANMLREQ VAQLKQKVMN HVNSGCQLML TQQLQTF