JUN_CAEEL
ID JUN_CAEEL Reviewed; 319 AA.
AC G5ECU7; B2CXX6; B2CXX7; B2CXX9; B5U8L4; G5EC66; G5EF64; Q5FC74;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Transcription factor jun-1 {ECO:0000312|WormBase:T24H10.7a};
DE AltName: Full=Transcription factor AP-1 subunit jun-1 {ECO:0000305};
GN Name=jun-1 {ECO:0000312|WormBase:T24H10.7a};
GN ORFNames=T24H10.7 {ECO:0000312|WormBase:T24H10.7a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000312|EMBL:ACB41727.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F), FUNCTION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=19570917; DOI=10.1091/mbc.e08-08-0833;
RA Hiatt S.M., Duren H.M., Shyu Y.J., Ellis R.E., Hisamoto N., Matsumoto K.,
RA Kariya K., Kerppola T.K., Hu C.D.;
RT "Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the
RT spermatheca to control ovulation.";
RL Mol. Biol. Cell 20:3888-3895(2009).
RN [2] {ECO:0000312|EMBL:CAB76416.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND PROBABLE INTERACTION WITH FOS-1.
RX PubMed=17942488; DOI=10.1242/dev.002741;
RA Oommen K.S., Newman A.P.;
RT "Co-regulation by Notch and Fos is required for cell fate specification of
RT intermediate precursors during C. elegans uterine development.";
RL Development 134:3999-4009(2007).
RN [4] {ECO:0000305}
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=24178943; DOI=10.1002/dvg.22723;
RA Gissendanner C.R., Cardin D., Dubose C.J., El Sayed M., Harmson J.S.,
RA Praslicka B., Rowan B.G.;
RT "C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1
RT transcription factor during spermatheca development.";
RL Genesis 52:29-38(2014).
CC -!- FUNCTION: Transcription factor that recognizes and binds to the AP-1
CC non-canonical enhancer heptamer motif 5'-TTAGTCA-3' (PubMed:17942488).
CC Required for ovulation (PubMed:19570917). Controls plc-1 expression in
CC the spermatheca to regulate spermathecal valve dilation
CC (PubMed:19570917). {ECO:0000269|PubMed:17942488,
CC ECO:0000269|PubMed:19570917}.
CC -!- SUBUNIT: Heterodimer; with fos-1. {ECO:0000305|PubMed:17942488}.
CC -!- INTERACTION:
CC G5ECU7; G5ECG2: fos-1; NbExp=3; IntAct=EBI-2414388, EBI-6728159;
CC G5ECU7; G5EBE5: zip-5; NbExp=3; IntAct=EBI-2414388, EBI-2414392;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978,
CC ECO:0000269|PubMed:24178943}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=a {ECO:0000312|WormBase:T24H10.7a};
CC IsoId=G5ECU7-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:T24H10.7b};
CC IsoId=G5ECU7-2; Sequence=VSP_057619;
CC Name=c {ECO:0000312|WormBase:T24H10.7c};
CC IsoId=G5ECU7-3; Sequence=VSP_057618;
CC Name=d {ECO:0000312|WormBase:T24H10.7d};
CC IsoId=G5ECU7-4; Sequence=VSP_057615;
CC Name=e {ECO:0000312|WormBase:T24H10.7e};
CC IsoId=G5ECU7-5; Sequence=VSP_057616;
CC Name=f {ECO:0000303|PubMed:19570917};
CC IsoId=G5ECU7-6; Sequence=VSP_057617;
CC -!- TISSUE SPECIFICITY: Isoform a, isoform b, isoform c and isoform d are
CC expressed in the spermatheca (PubMed:19570917, PubMed:24178943).
CC {ECO:0000269|PubMed:19570917, ECO:0000269|PubMed:24178943}.
CC -!- DEVELOPMENTAL STAGE: Expressed in all cells of the developing
CC spermatheca and in the spermatheca-uterine junction core cells at
CC larval stage L4. {ECO:0000269|PubMed:24178943}.
CC -!- DISRUPTION PHENOTYPE: Sixty percent of animals display an egg laying
CC defective phenotype. Animals display numerous defects in the
CC reproductive system and have a reduced brood size.
CC {ECO:0000269|PubMed:19570917}.
CC -!- SIMILARITY: Belongs to the bZIP family. Jun subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION: [Isoform b]:
CC Sequence=CAI46586.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU553920; ACB41727.1; -; mRNA.
DR EMBL; EU553921; ACB41728.1; -; mRNA.
DR EMBL; EU553922; ACB41729.1; -; mRNA.
DR EMBL; EU553923; ACB41730.1; -; mRNA.
DR EMBL; EU553924; ACB41731.1; -; mRNA.
DR EMBL; EU553925; ACB41732.1; -; mRNA.
DR EMBL; Z54216; CAB76416.2; -; Genomic_DNA.
DR EMBL; Z54216; CAI46586.1; ALT_INIT; Genomic_DNA.
DR EMBL; Z54216; CAR64685.1; -; Genomic_DNA.
DR EMBL; Z54216; CAN86906.1; -; Genomic_DNA.
DR EMBL; Z54216; CAA90948.1; -; Genomic_DNA.
DR PIR; T25255; T25255.
DR RefSeq; NP_001022366.1; NM_001027195.3. [G5ECU7-1]
DR RefSeq; NP_001022367.1; NM_001027196.3.
DR RefSeq; NP_001022368.1; NM_001027197.3. [G5ECU7-6]
DR RefSeq; NP_001122643.1; NM_001129171.2.
DR RefSeq; NP_001129827.1; NM_001136355.2. [G5ECU7-5]
DR AlphaFoldDB; G5ECU7; -.
DR SMR; G5ECU7; -.
DR IntAct; G5ECU7; 27.
DR STRING; 6239.T24H10.7a; -.
DR EPD; G5ECU7; -.
DR PaxDb; G5ECU7; -.
DR PeptideAtlas; G5ECU7; -.
DR EnsemblMetazoa; T24H10.7a.1; T24H10.7a.1; WBGene00012005. [G5ECU7-1]
DR EnsemblMetazoa; T24H10.7b.1; T24H10.7b.1; WBGene00012005.
DR EnsemblMetazoa; T24H10.7c.1; T24H10.7c.1; WBGene00012005. [G5ECU7-6]
DR EnsemblMetazoa; T24H10.7d.1; T24H10.7d.1; WBGene00012005. [G5ECU7-4]
DR EnsemblMetazoa; T24H10.7e.1; T24H10.7e.1; WBGene00012005. [G5ECU7-5]
DR GeneID; 174452; -.
DR KEGG; cel:CELE_T24H10.7; -.
DR UCSC; T24H10.7a; c. elegans.
DR CTD; 174452; -.
DR WormBase; T24H10.7a; CE37850; WBGene00012005; jun-1. [G5ECU7-1]
DR WormBase; T24H10.7b; CE37851; WBGene00012005; jun-1.
DR WormBase; T24H10.7c; CE16461; WBGene00012005; jun-1. [G5ECU7-6]
DR WormBase; T24H10.7d; CE41026; WBGene00012005; jun-1. [G5ECU7-4]
DR WormBase; T24H10.7e; CE43044; WBGene00012005; jun-1. [G5ECU7-5]
DR eggNOG; KOG0837; Eukaryota.
DR InParanoid; G5ECU7; -.
DR OMA; MVERHSV; -.
DR OrthoDB; 1401336at2759; -.
DR Reactome; R-CEL-2559580; Oxidative Stress Induced Senescence.
DR Reactome; R-CEL-2871796; FCERI mediated MAPK activation.
DR Reactome; R-CEL-450341; Activation of the AP-1 family of transcription factors.
DR SignaLink; G5ECU7; -.
DR PRO; PR:G5ECU7; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00012005; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; G5ECU7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:WormBase.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0033120; P:positive regulation of RNA splicing; IMP:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042594; P:response to starvation; IMP:UniProtKB.
DR GO; GO:0009636; P:response to toxic substance; IMP:UniProtKB.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR002112; Leuzip_Jun.
DR PRINTS; PR00043; LEUZIPPRJUN.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..319
FT /note="Transcription factor jun-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000432856"
FT DOMAIN 244..307
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..285
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 286..293
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 37..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..236
FT /note="MEEDQEEPPSSSTSSESPEVVLKAPKAPTRRRKNSKKDRRQDMEVDDGEKES
FT TAQYCKGFYDALRVMQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSL
FT LGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTT
FT AVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDS
FT RSASRCG -> MLNWGHHHNSYDEPSASSSSGSSSSSVAANLSVSYNSDSRNQGCMGGG
FT QYSGNIGGGGGGYGDYSHIDPINM (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_057615"
FT VAR_SEQ 1..236
FT /note="MEEDQEEPPSSSTSSESPEVVLKAPKAPTRRRKNSKKDRRQDMEVDDGEKES
FT TAQYCKGFYDALRVMQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSL
FT LGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTT
FT AVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDS
FT RSASRCG -> MLNYQPPQWMNSLMNSNIPSSLTLTPTPQFPIMFSSTSPFNFCTSDSS
FT SSPISADSTPKSSPFFGDANPKFPFFNFMNGDS (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_057616"
FT VAR_SEQ 1..236
FT /note="MEEDQEEPPSSSTSSESPEVVLKAPKAPTRRRKNSKKDRRQDMEVDDGEKES
FT TAQYCKGFYDALRVMQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSL
FT LGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTT
FT AVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDS
FT RSASRCG -> MVWSSETFGMTPEEQIEW (in isoform f)"
FT /id="VSP_057617"
FT VAR_SEQ 1..66
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_057618"
FT VAR_SEQ 2..38
FT /note="EEDQEEPPSSSTSSESPEVVLKAPKAPTRRRKNSKKD -> MNNSFDMNVTQ
FT HTNSSPY (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_057619"
FT CONFLICT 199
FT /note="D -> G (in Ref. 2; ACB41728/CAI46586)"
FT /evidence="ECO:0000305"
FT CONFLICT G5ECU7-5:32
FT /note="I -> T (in Ref. 1; ACB41731)"
FT /evidence="ECO:0000305"
FT CONFLICT G5ECU7-5:40
FT /note="F -> Y (in Ref. 1; ACB41731)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 319 AA; 34798 MW; 401F469DF7290760 CRC64;
MEEDQEEPPS SSTSSESPEV VLKAPKAPTR RRKNSKKDRR QDMEVDDGEK ESTAQYCKGF
YDALRVMQTT NKYEFTGGAV SSPVLPVLQT AAFSPITPAS ASDMHTIVMS LLGNTPITSG
PSIAPLSSPT LLPLVTSGDL DDLSMKILAS SAIPGPPIIS SSNSPDSSTT AVTTSQITAF
QPLLNNFVSS TTASTSRPDK LNLTPPQQSA EIYAFNGVNS DDSDGGLDSR SASRCGMALD
DQEKKKLERK RARNRQAATK CRQKKMDRIK ELEEQVLHEK HRGQRLDAEL LELNRALEHF
RRTVEHHSGN GCPNNSIRV
