ID   JUN_COTJA               Reviewed;         313 AA.
AC   P12981;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Transcription factor Jun {ECO:0000305};
DE   AltName: Full=Proto-oncogene c-Jun;
DE   AltName: Full=Transcription factor AP-1 subunit Jun {ECO:0000305};
GN   Name=JUN;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2505235; DOI=10.1093/nar/17.15.6393;
RA   Brun G., la Vista N., Dangy J.-P., Castellazzi M.;
RT   "Nucleotide sequence of the quail c-jun protooncogene.";
RL   Nucleic Acids Res. 17:6393-6393(1989).
CC   -!- FUNCTION: Transcription factor that recognizes and binds to the
CC       enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated
CC       KRAS-mediated transcriptional activation of USP28. May bind to the
CC       USP28 promoter. {ECO:0000250|UniProtKB:P05412}.
CC   -!- SUBUNIT: Interacts with FOS to form a dimer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the bZIP family. Jun subfamily. {ECO:0000305}.
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DR   EMBL; X15547; CAA33553.1; -; mRNA.
DR   PIR; S05963; TVQJUN.
DR   AlphaFoldDB; P12981; -.
DR   BMRB; P12981; -.
DR   SMR; P12981; -.
DR   Proteomes; UP000694412; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0007265; P:Ras protein signal transduction; ISS:UniProtKB.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR015558; C_Jun/v-Jun.
DR   InterPro; IPR005643; JNK.
DR   InterPro; IPR002112; Leuzip_Jun.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   PANTHER; PTHR11462:SF8; PTHR11462:SF8; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   Pfam; PF03957; Jun; 1.
DR   PRINTS; PR00043; LEUZIPPRJUN.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF47454; SSF47454; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Proto-oncogene; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..313
FT                   /note="Transcription factor Jun"
FT                   /id="PRO_0000076434"
FT   DOMAIN          234..297
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          234..261
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          262..290
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ   SEQUENCE   313 AA;  34341 MW;  24A88C7FF6A0842E CRC64;
     MSAKMEPTFY EDALNASFAP PESAYGYNNA KVLKQSMTLN LSDPASSLKP HLRNKNADIL
     TSPDVGLLKL ASPELERLII QSSNGLITTT PTPTQFLCPK NVTDEQEGFA EGFVRALAEL
     HNQNTLPSVT SAAQPVSGGM APVSSMAGGG SFNTSLHSEP PVYANLSNFN PNALNSAPNY
     NANGMGYAPQ HHINPQMPVQ HPRLQALKEE PQTVPEMPGE TPPLSPIDME SQERIKAERK
     RMRNRIAASK CRKRKLERIA RLEEKVKTLK AQNSELASTA NMLREQVAQL KQKVMNHVNS
     GCQLMLTQQL QTF