JUN_SERCA
ID JUN_SERCA Reviewed; 314 AA.
AC P54864;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Transcription factor Jun {ECO:0000305};
DE AltName: Full=Proto-oncogene c-Jun;
DE AltName: Full=Transcription factor AP-1 subunit Jun {ECO:0000305};
GN Name=JUN;
OS Serinus canaria (Island canary) (Fringilla canaria).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Fringillidae;
OC Carduelinae; Serinus.
OX NCBI_TaxID=9135;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wasserschlager; TISSUE=Brain;
RX PubMed=7898314; DOI=10.1016/0169-328x(94)90013-2;
RA Nastiuk K.L., Mello C.V., George J.M., Clayton D.F.;
RT "Immediate-early gene responses in the avian song control system: cloning
RT and expression analysis of the canary c-jun cDNA.";
RL Brain Res. Mol. Brain Res. 27:299-309(1994).
CC -!- FUNCTION: Transcription factor that recognizes and binds to the
CC enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated
CC KRAS-mediated transcriptional activation of USP28. May bind to the
CC USP28 promoter. {ECO:0000250|UniProtKB:P05412}.
CC -!- SUBUNIT: Interacts with FOS to form a dimer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the bZIP family. Jun subfamily. {ECO:0000305}.
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DR EMBL; L35273; AAA49537.1; -; mRNA.
DR RefSeq; XP_009087016.1; XM_009088768.1.
DR AlphaFoldDB; P54864; -.
DR SMR; P54864; -.
DR GeneID; 103815057; -.
DR KEGG; scan:103815057; -.
DR CTD; 3725; -.
DR Proteomes; UP000694409; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0007265; P:Ras protein signal transduction; ISS:UniProtKB.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR015558; C_Jun/v-Jun.
DR InterPro; IPR005643; JNK.
DR InterPro; IPR002112; Leuzip_Jun.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR PANTHER; PTHR11462:SF8; PTHR11462:SF8; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF03957; Jun; 1.
DR PRINTS; PR00043; LEUZIPPRJUN.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; SSF47454; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Proto-oncogene; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..314
FT /note="Transcription factor Jun"
FT /id="PRO_0000076435"
FT DOMAIN 235..298
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 235..262
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 263..291
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 314 AA; 34518 MW; 87E936AC37AC2731 CRC64;
MSAKMEPTFY EDALSAGFAP PESGGYGYNN AKVLKQNMTL NLSDPSSNLK PHLRNKNADI
LTSPDVGLLK LASPELERLI IQSSNGLITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE
LHNQNTLPSV TSAAQPVTSG MAPVSSMAGS TSFNTSLHSE PPVYANLSNF NPNALSSAPN
YNANSMGYAP QHHINPQMPV QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER
KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN
SGCQLMLTQQ LQTF