JUPI2_MOUSE
ID JUPI2_MOUSE Reviewed; 190 AA.
AC Q6PGH2;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Jupiter microtubule associated homolog 2 {ECO:0000250|UniProtKB:Q9H910};
DE AltName: Full=Hematological and neurological expressed 1-like protein {ECO:0000250|UniProtKB:Q9H910};
DE Short=HN1-like protein {ECO:0000250|UniProtKB:Q9H910};
GN Name=Jpt2 {ECO:0000250|UniProtKB:Q9H910};
GN Synonyms=D17Ertd441e, Hn1l {ECO:0000312|MGI:MGI:1196260};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Embryonic germ cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND LYS-11, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding
CC protein required for NAADP-evoked intracellular calcium release.
CC Confers NAADP-sensitivity to the two pore channels (TPCs) complex.
CC Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum
CC through ryanodine receptors. {ECO:0000250|UniProtKB:Q9H910}.
CC -!- SUBUNIT: Monomer. Dimer. Interacts with TPCN1.
CC {ECO:0000250|UniProtKB:Q9H910}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H910}. Nucleus
CC {ECO:0000250|UniProtKB:Q9H910}. Note=Colocalizes with type 1 ryanodine
CC receptor (RYR1). {ECO:0000250|UniProtKB:Q9H910}.
CC -!- SIMILARITY: Belongs to the JUPITER family. {ECO:0000305}.
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DR EMBL; BC057024; AAH57024.1; -; mRNA.
DR EMBL; BC080740; AAH80740.1; -; mRNA.
DR CCDS; CCDS28504.1; -.
DR RefSeq; NP_945175.1; NM_198937.2.
DR AlphaFoldDB; Q6PGH2; -.
DR BioGRID; 206322; 1.
DR STRING; 10090.ENSMUSP00000024981; -.
DR iPTMnet; Q6PGH2; -.
DR PhosphoSitePlus; Q6PGH2; -.
DR SwissPalm; Q6PGH2; -.
DR EPD; Q6PGH2; -.
DR jPOST; Q6PGH2; -.
DR MaxQB; Q6PGH2; -.
DR PaxDb; Q6PGH2; -.
DR PRIDE; Q6PGH2; -.
DR ProteomicsDB; 269037; -.
DR Antibodypedia; 23196; 81 antibodies from 15 providers.
DR DNASU; 52009; -.
DR Ensembl; ENSMUST00000024981; ENSMUSP00000024981; ENSMUSG00000024165.
DR Ensembl; ENSMUST00000233067; ENSMUSP00000156651; ENSMUSG00000024165.
DR GeneID; 52009; -.
DR KEGG; mmu:52009; -.
DR UCSC; uc008azi.1; mouse.
DR CTD; 90861; -.
DR MGI; MGI:1196260; Jpt2.
DR VEuPathDB; HostDB:ENSMUSG00000024165; -.
DR eggNOG; ENOG502S1G7; Eukaryota.
DR GeneTree; ENSGT00390000007652; -.
DR HOGENOM; CLU_111612_0_0_1; -.
DR InParanoid; Q6PGH2; -.
DR OMA; MLKNHEP; -.
DR OrthoDB; 1620782at2759; -.
DR PhylomeDB; Q6PGH2; -.
DR TreeFam; TF327169; -.
DR BioGRID-ORCS; 52009; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Jpt2; mouse.
DR PRO; PR:Q6PGH2; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6PGH2; protein.
DR Bgee; ENSMUSG00000024165; Expressed in manus and 209 other tissues.
DR ExpressionAtlas; Q6PGH2; baseline and differential.
DR Genevisible; Q6PGH2; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:Ensembl.
DR GO; GO:0050848; P:regulation of calcium-mediated signaling; IEA:Ensembl.
DR InterPro; IPR033335; JUPITER.
DR PANTHER; PTHR34930; PTHR34930; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..190
FT /note="Jupiter microtubule associated homolog 2"
FT /id="PRO_0000054922"
FT REGION 1..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 11
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H910"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H910"
FT MOD_RES 69
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H910"
FT MOD_RES 144
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H910"
SQ SEQUENCE 190 AA; 20020 MW; 5EE3B54AFDBFA26E CRC64;
MFQGADSQAG KSGSRSMKPP GGESSDLFGS PEEGISSSKP NRMASNIFGP TEEPKNIPKR
TNPPGGKGSG IFDESTPVQT RQRLNPPGGK TSDIFGSPVT ATAPLAHPNK PKDHVLLCEG
EDSKSDLKAA TDSTPRGEQS DKGSSKEVEH AKIPEPTPTV DSHEPRLGPR PRSHNKVLNP
PGGKSSLSFY
