ID   JUPI2_RAT               Reviewed;         190 AA.
AC   Q5BK20;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Jupiter microtubule associated homolog 2 {ECO:0000250|UniProtKB:Q9H910};
DE   AltName: Full=Hematological and neurological expressed 1-like protein {ECO:0000250|UniProtKB:Q9H910};
DE            Short=HN1-like protein {ECO:0000250|UniProtKB:Q9H910};
GN   Name=Jpt2 {ECO:0000250|UniProtKB:Q9H910};
GN   Synonyms=Hn1l {ECO:0000312|RGD:1305117};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=33758062; DOI=10.1126/scisignal.abd5647;
RA   Roggenkamp H.G., Khansahib I., Hernandez C.L.C., Zhang Y., Lodygin D.,
RA   Krueger A., Gu F., Moeckl F., Loehndorf A., Wolters V., Woike D.,
RA   Rosche A., Bauche A., Schetelig D., Werner R., Schlueter H., Failla A.V.,
RA   Meier C., Fliegert R., Walseth T.F., Fluegel A., Diercks B.P., Guse A.H.;
RT   "HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+
RT   microdomain formation.";
RL   Sci. Signal. 14:0-0(2021).
CC   -!- FUNCTION: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding
CC       protein required for NAADP-evoked intracellular calcium release.
CC       Confers NAADP-sensitivity to the two pore channels (TPCs) complex (By
CC       similarity). Enables NAADP to activate Ca(2+) release from the
CC       endoplasmic reticulum through ryanodine receptors (PubMed:33758062).
CC       {ECO:0000250|UniProtKB:Q9H910, ECO:0000269|PubMed:33758062}.
CC   -!- SUBUNIT: Monomer. Dimer. Interacts with TPCN1.
CC       {ECO:0000250|UniProtKB:Q9H910}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H910}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9H910}. Note=Colocalizes with type 1 ryanodine
CC       receptor (RYR1). {ECO:0000250|UniProtKB:Q9H910}.
CC   -!- SIMILARITY: Belongs to the JUPITER family. {ECO:0000305}.
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DR   EMBL; BC091238; AAH91238.1; -; mRNA.
DR   RefSeq; NP_001013200.1; NM_001013182.1.
DR   AlphaFoldDB; Q5BK20; -.
DR   STRING; 10116.ENSRNOP00000035954; -.
DR   iPTMnet; Q5BK20; -.
DR   PhosphoSitePlus; Q5BK20; -.
DR   jPOST; Q5BK20; -.
DR   PaxDb; Q5BK20; -.
DR   PRIDE; Q5BK20; -.
DR   Ensembl; ENSRNOT00000035513; ENSRNOP00000035954; ENSRNOG00000024661.
DR   GeneID; 360492; -.
DR   KEGG; rno:360492; -.
DR   UCSC; RGD:1305117; rat.
DR   CTD; 90861; -.
DR   RGD; 1305117; Jpt2.
DR   eggNOG; ENOG502S1G7; Eukaryota.
DR   GeneTree; ENSGT00390000007652; -.
DR   InParanoid; Q5BK20; -.
DR   OMA; MLKNHEP; -.
DR   OrthoDB; 1620782at2759; -.
DR   PhylomeDB; Q5BK20; -.
DR   TreeFam; TF327169; -.
DR   PRO; PR:Q5BK20; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000024661; Expressed in thymus and 18 other tissues.
DR   ExpressionAtlas; Q5BK20; baseline and differential.
DR   Genevisible; Q5BK20; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   InterPro; IPR033335; JUPITER.
DR   PANTHER; PTHR34930; PTHR34930; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Jupiter microtubule associated homolog 2"
FT                   /id="PRO_0000054923"
FT   REGION          1..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H910"
FT   MOD_RES         11
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PGH2"
FT   MOD_RES         30
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H910"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H910"
FT   MOD_RES         69
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H910"
FT   MOD_RES         97
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H910"
FT   MOD_RES         144
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H910"
SQ   SEQUENCE   190 AA;  20070 MW;  A7450D7291866B77 CRC64;
     MFRGADGQAS KSGFRSMKPP GGESNDIFGS PEEGVPSSKP HRMASNIFGP TEEPKNIPKR
     TNPPGGKGSG IFDESTPVQT RQRLNPPGGK TSDIFGSPVT ATAPLAHPNK PKDHVLLCEG
     EDCKSDLKAA TNSTPRGEQG EKGSSTEAEP AKIPEPIPTV DSHEPRLGPR PRSHNKVLNP
     PGGKSSISFY