JUPIT_DROME
ID JUPIT_DROME Reviewed; 208 AA.
AC Q9I7K0; Q8IGC9; Q8IGZ9; Q8IH61; Q8INK0; Q8INK1; Q8SXM9; Q8T0S5; Q9I7K1;
AC Q9VGL5; Q9VGL6;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Microtubule-associated protein Jupiter {ECO:0000303|PubMed:16518797};
GN Name=Jupiter {ECO:0000312|EMBL:AAG22143.2};
GN Synonyms=G147 {ECO:0000303|PubMed:11742088}; ORFNames=CG31363;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=16518797; DOI=10.1002/cm.20124;
RA Karpova N., Bobinnec Y., Fouix S., Huitorel P., Debec A.;
RT "Jupiter, a new Drosophila protein associated with microtubules.";
RL Cell Motil. Cytoskeleton 63:301-312(2006).
RN [2] {ECO:0000312|EMBL:AAG22143.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAG22143.2}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAN71153.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A; B; D AND H).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAN71153.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569}, and
RC Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305, ECO:0000312|EMBL:AAN71268.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS C AND H).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAN71268.2}; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kapadia B., Kronmiller B., Li P.W., Liao G.,
RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,
RA Celniker S.E.;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000305}
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; THR-41; THR-102; SER-111
RP AND SER-150, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [7] {ECO:0000305}
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-98; THR-102; SER-139 AND
RP SER-150, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo {ECO:0000269|PubMed:18327897};
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
RN [8] {ECO:0000305}
RP IDENTIFICATION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11742088; DOI=10.1073/pnas.261408198;
RA Morin X., Daneman R., Zavortink M., Chia W.;
RT "A protein trap strategy to detect GFP-tagged proteins expressed from their
RT endogenous loci in Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:15050-15055(2001).
CC -!- FUNCTION: Binds to all microtubule populations.
CC {ECO:0000269|PubMed:16518797}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11742088,
CC ECO:0000269|PubMed:16518797}. Cytoplasm {ECO:0000269|PubMed:11742088,
CC ECO:0000269|PubMed:16518797}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:11742088, ECO:0000269|PubMed:16518797}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000269|PubMed:11742088,
CC ECO:0000269|PubMed:16518797}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=E {ECO:0000269|PubMed:10731132};
CC IsoId=Q9I7K0-1; Sequence=Displayed;
CC Name=A {ECO:0000269|PubMed:10731132};
CC IsoId=Q9I7K0-2; Sequence=VSP_052969, VSP_052970, VSP_052971;
CC Name=B {ECO:0000269|PubMed:10731132};
CC IsoId=Q9I7K0-3; Sequence=VSP_052968;
CC Name=C {ECO:0000269|PubMed:10731132};
CC IsoId=Q9I7K0-4; Sequence=VSP_052970;
CC Name=D {ECO:0000269|PubMed:16518797};
CC IsoId=Q9I7K0-5; Sequence=VSP_052969, VSP_052970;
CC Name=H {ECO:0000269|PubMed:10731132};
CC IsoId=Q9I7K0-6; Sequence=VSP_052969;
CC -!- TISSUE SPECIFICITY: Ubiquitous expression throughout development.
CC Expressed during cell division in the syncytial embryo. Expressed in
CC developing photoreceptors of the eye imaginal disk of the third larval
CC stage. In adults, highly expressed in neurons of the brain,
CC concentrated in axons. In the adult ovaries, expression accumulates in
CC the germarium and the polar follicular cells as well as in the oocyte
CC along the microtubule network. {ECO:0000269|PubMed:11742088,
CC ECO:0000269|PubMed:16518797}.
CC -!- SIMILARITY: Belongs to the MAP Jupiter family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL90282.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAN71153.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAN71604.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF54661.3; -; Genomic_DNA.
DR EMBL; AE014297; AAF54662.3; -; Genomic_DNA.
DR EMBL; AE014297; AAG22142.2; -; Genomic_DNA.
DR EMBL; AE014297; AAG22143.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13515.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13516.1; -; Genomic_DNA.
DR EMBL; AY069089; AAL39234.1; -; mRNA.
DR EMBL; AY089544; AAL90282.1; ALT_FRAME; mRNA.
DR EMBL; BT001398; AAN71153.1; ALT_INIT; mRNA.
DR EMBL; BT001843; AAN71604.1; ALT_SEQ; mRNA.
DR EMBL; BT001513; AAN71268.2; -; mRNA.
DR EMBL; BT006004; AAO74687.1; -; mRNA.
DR RefSeq; NP_731595.1; NM_169404.4. [Q9I7K0-5]
DR RefSeq; NP_731596.1; NM_169405.4. [Q9I7K0-2]
DR RefSeq; NP_731597.1; NM_169406.4. [Q9I7K0-6]
DR RefSeq; NP_731598.1; NM_169407.4. [Q9I7K0-4]
DR RefSeq; NP_731599.1; NM_169408.4. [Q9I7K0-1]
DR RefSeq; NP_731600.1; NM_169409.4. [Q9I7K0-3]
DR AlphaFoldDB; Q9I7K0; -.
DR BioGRID; 66520; 37.
DR IntAct; Q9I7K0; 2.
DR STRING; 7227.FBpp0081930; -.
DR iPTMnet; Q9I7K0; -.
DR PaxDb; Q9I7K0; -.
DR PRIDE; Q9I7K0; -.
DR DNASU; 41392; -.
DR EnsemblMetazoa; FBtr0082452; FBpp0081928; FBgn0051363. [Q9I7K0-5]
DR EnsemblMetazoa; FBtr0082453; FBpp0081929; FBgn0051363. [Q9I7K0-6]
DR EnsemblMetazoa; FBtr0082454; FBpp0081930; FBgn0051363. [Q9I7K0-1]
DR EnsemblMetazoa; FBtr0082455; FBpp0081931; FBgn0051363. [Q9I7K0-4]
DR EnsemblMetazoa; FBtr0082456; FBpp0081932; FBgn0051363. [Q9I7K0-2]
DR EnsemblMetazoa; FBtr0082457; FBpp0081933; FBgn0051363. [Q9I7K0-3]
DR GeneID; 41392; -.
DR KEGG; dme:Dmel_CG31363; -.
DR UCSC; CG31363-RA; d. melanogaster.
DR UCSC; CG31363-RB; d. melanogaster.
DR UCSC; CG31363-RC; d. melanogaster.
DR UCSC; CG31363-RD; d. melanogaster.
DR UCSC; CG31363-RE; d. melanogaster. [Q9I7K0-1]
DR UCSC; CG31363-RH; d. melanogaster.
DR CTD; 41392; -.
DR FlyBase; FBgn0051363; Jupiter.
DR VEuPathDB; VectorBase:FBgn0051363; -.
DR eggNOG; ENOG502S7TC; Eukaryota.
DR HOGENOM; CLU_076719_0_0_1; -.
DR InParanoid; Q9I7K0; -.
DR OMA; GANDFHQ; -.
DR PhylomeDB; Q9I7K0; -.
DR SignaLink; Q9I7K0; -.
DR BioGRID-ORCS; 41392; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Jupiter; fly.
DR GenomeRNAi; 41392; -.
DR PRO; PR:Q9I7K0; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0051363; Expressed in eye disc (Drosophila) and 40 other tissues.
DR ExpressionAtlas; Q9I7K0; baseline and differential.
DR Genevisible; Q9I7K0; DM.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IDA:UniProtKB.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
DR InterPro; IPR033335; JUPITER.
DR PANTHER; PTHR34930; PTHR34930; 2.
DR Pfam; PF17054; JUPITER; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..208
FT /note="Microtubule-associated protein Jupiter"
FT /id="PRO_0000355128"
FT REGION 24..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 41
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 98
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 102
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:17372656,
FT ECO:0000269|PubMed:18327897"
FT MOD_RES 111
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 139
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 150
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656,
FT ECO:0000269|PubMed:18327897"
FT VAR_SEQ 2..162
FT /note="AAYAAFKHVELYNVGKAKKRVLRPPGGGSSDIFGSEMPQTPRNVKNRMASNI
FT FAAEKDNGVKNNVRQGAHRFYFIGDAPRRGQKTVDSHSRLFGEPTRPITPGKNHMKSSI
FT PFGQNTEAVAAQKLLTTNGHYNGKSGSVSSASSSVSSSTENLKMNSGSRS -> STRPD
FT TKETSPRVSLCPPEPARTETPIPPADDALSIDNSCRDSEVGDVPADNSTVTKSDQVNEG
FT CQTRRDSGNNPEQPYSLNKMAGVSNVKEPLGLCPNEIKEEQQACSKLDSRNPITGLGLN
FT GDGVGGLKPKKLKIR (in isoform B)"
FT /evidence="ECO:0000303|PubMed:10731132,
FT ECO:0000303|PubMed:12537569"
FT /id="VSP_052968"
FT VAR_SEQ 2..21
FT /note="AAYAAFKHVELYNVGKAKKR -> ISNFDCTDNQASSK (in isoform
FT A, isoform D and isoform H)"
FT /evidence="ECO:0000303|PubMed:10731132,
FT ECO:0000303|PubMed:12537569, ECO:0000303|PubMed:16518797,
FT ECO:0000303|Ref.5"
FT /id="VSP_052969"
FT VAR_SEQ 66..76
FT /note="Missing (in isoform A, isoform C and isoform D)"
FT /evidence="ECO:0000303|PubMed:10731132,
FT ECO:0000303|PubMed:12537569, ECO:0000303|PubMed:16518797,
FT ECO:0000303|Ref.5"
FT /id="VSP_052970"
FT VAR_SEQ 162..163
FT /note="SE -> SVFRNMSK (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10731132,
FT ECO:0000303|PubMed:12537569"
FT /id="VSP_052971"
FT CONFLICT 78
FT /note="D -> T (in Ref. 4; AAN71604)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 208 AA; 22319 MW; 438A7E64A81B77AF CRC64;
MAAYAAFKHV ELYNVGKAKK RVLRPPGGGS SDIFGSEMPQ TPRNVKNRMA SNIFAAEKDN
GVKNNVRQGA HRFYFIGDAP RRGQKTVDSH SRLFGEPTRP ITPGKNHMKS SIPFGQNTEA
VAAQKLLTTN GHYNGKSGSV SSASSSVSSS TENLKMNSGS RSEGNPVTGE GYKVVANEYS
QRQESSNGGT PVINKNRIPP GGYSSGLW
