JZ13C_CHIGU
ID JZ13C_CHIGU Reviewed; 66 AA.
AC B1P1C8;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=U10-theraphotoxin-Cg1a 3;
DE Short=U10-TRTX-Cg1a;
DE AltName: Full=Jingzhaotoxin-13.3 {ECO:0000312|EMBL:ABY71678.1};
DE Short=JZTX-13.3 {ECO:0000312|EMBL:ABY71678.1};
DE AltName: Full=Peptide F5-18.88 {ECO:0000303|PubMed:17476710};
DE Flags: Precursor;
OS Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS jingzhao).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Chilobrachys.
OX NCBI_TaxID=278060;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT Chilobrachys jingzhao.";
RL Cell. Mol. Life Sci. 65:2431-2444(2008).
RN [2]
RP PROTEIN SEQUENCE OF 30-41, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Venom;
RX PubMed=17476710; DOI=10.1002/pmic.200600785;
RA Liao Z., Cao J., Li S., Yan X., Hu W., He Q., Chen J., Tang J., Xie J.,
RA Liang S.;
RT "Proteomic and peptidomic analysis of the venom from Chinese tarantula
RT Chilobrachys jingzhao.";
RL Proteomics 7:1892-1907(2007).
CC -!- FUNCTION: Probable ion channel inhibitor.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 29 (Jztx-13)
CC subfamily. {ECO:0000305}.
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DR EMBL; EU233859; ABY71678.1; -; mRNA.
DR AlphaFoldDB; B1P1C8; -.
DR SMR; B1P1C8; -.
DR ArachnoServer; AS000807; U10-theraphotoxin-Cg1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR011696; Huwentoxin-1.
DR InterPro; IPR013140; Huwentoxin_CS1.
DR Pfam; PF07740; Toxin_12; 1.
DR PROSITE; PS60021; HWTX_1; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..29
FT /evidence="ECO:0000250"
FT /id="PRO_0000398423"
FT PEPTIDE 30..66
FT /note="U10-theraphotoxin-Cg1a 3"
FT /id="PRO_0000398424"
FT DISULFID 31..46
FT /evidence="ECO:0000250"
FT DISULFID 38..51
FT /evidence="ECO:0000250"
FT DISULFID 45..58
FT /evidence="ECO:0000250"
SQ SEQUENCE 66 AA; 7377 MW; F48022B89A9E566A CRC64;
MKTSVLFVIF GLALLFCLSF ADELEDTGRQ CGEFMWKCGA GKPTCCSGYD CSPTWKWCVL
KSPGRR