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JZ432_CHIGU
ID   JZ432_CHIGU             Reviewed;          32 AA.
AC   P0CH50;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Jingzhaotoxin F4-32.60 {ECO:0000303|PubMed:17476710};
DE   AltName: Full=Peptide F4-32.60 {ECO:0000303|PubMed:17476710};
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT
RP   ASP-31.
RC   TISSUE=Venom;
RX   PubMed=17476710; DOI=10.1002/pmic.200600785;
RA   Liao Z., Cao J., Li S., Yan X., Hu W., He Q., Chen J., Tang J., Xie J.,
RA   Liang S.;
RT   "Proteomic and peptidomic analysis of the venom from Chinese tarantula
RT   Chilobrachys jingzhao.";
RL   Proteomics 7:1892-1907(2007).
CC   -!- FUNCTION: Probable ion channel inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- PTM: Amidated as well as non-amidated forms are found in the venom.
CC       {ECO:0000269|PubMed:17476710}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 30 (Jztx-14)
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CH50; -.
DR   SMR; P0CH50; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   Pfam; PF07740; Toxin_12; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Secreted; Toxin.
FT   PEPTIDE         1..31
FT                   /note="Jingzhaotoxin F4-32.60"
FT                   /id="PRO_0000398559"
FT   MOD_RES         31
FT                   /note="Aspartic acid 1-amide"
FT                   /evidence="ECO:0000269|PubMed:17476710"
FT   DISULFID        2..17
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..22
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..29
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   32 AA;  3487 MW;  F7E655812571367F CRC64;
     GCQKFFWTCH PGQPPCCSGL ACTWPTEICI DG
 
 
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