JZ432_CHIGU
ID JZ432_CHIGU Reviewed; 32 AA.
AC P0CH50;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 25-MAY-2022, entry version 22.
DE RecName: Full=Jingzhaotoxin F4-32.60 {ECO:0000303|PubMed:17476710};
DE AltName: Full=Peptide F4-32.60 {ECO:0000303|PubMed:17476710};
OS Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS jingzhao).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Chilobrachys.
OX NCBI_TaxID=278060;
RN [1]
RP PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT
RP ASP-31.
RC TISSUE=Venom;
RX PubMed=17476710; DOI=10.1002/pmic.200600785;
RA Liao Z., Cao J., Li S., Yan X., Hu W., He Q., Chen J., Tang J., Xie J.,
RA Liang S.;
RT "Proteomic and peptidomic analysis of the venom from Chinese tarantula
RT Chilobrachys jingzhao.";
RL Proteomics 7:1892-1907(2007).
CC -!- FUNCTION: Probable ion channel inhibitor.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- PTM: Amidated as well as non-amidated forms are found in the venom.
CC {ECO:0000269|PubMed:17476710}.
CC -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 30 (Jztx-14)
CC subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0CH50; -.
DR SMR; P0CH50; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR011696; Huwentoxin-1.
DR Pfam; PF07740; Toxin_12; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond;
KW Ion channel impairing toxin; Knottin; Secreted; Toxin.
FT PEPTIDE 1..31
FT /note="Jingzhaotoxin F4-32.60"
FT /id="PRO_0000398559"
FT MOD_RES 31
FT /note="Aspartic acid 1-amide"
FT /evidence="ECO:0000269|PubMed:17476710"
FT DISULFID 2..17
FT /evidence="ECO:0000250"
FT DISULFID 9..22
FT /evidence="ECO:0000250"
FT DISULFID 16..29
FT /evidence="ECO:0000250"
SQ SEQUENCE 32 AA; 3487 MW; F7E655812571367F CRC64;
GCQKFFWTCH PGQPPCCSGL ACTWPTEICI DG