ID   JZ47A_CHIGU             Reviewed;          87 AA.
AC   B1P1A7;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=U3-theraphotoxin-Cg1b {ECO:0000305};
DE            Short=U3-TRTX-Cg1b {ECO:0000305};
DE   AltName: Full=Jingzhaotoxin-47 {ECO:0000305};
DE            Short=JZTX-47 {ECO:0000312|EMBL:ABY71657.1};
DE   AltName: Full=Peptide F6-10.40 {ECO:0000303|PubMed:17476710};
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
RN   [2]
RP   PROTEIN SEQUENCE OF 49-87, IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=17476710; DOI=10.1002/pmic.200600785;
RA   Liao Z., Cao J., Li S., Yan X., Hu W., He Q., Chen J., Tang J., Xie J.,
RA   Liang S.;
RT   "Proteomic and peptidomic analysis of the venom from Chinese tarantula
RT   Chilobrachys jingzhao.";
RL   Proteomics 7:1892-1907(2007).
CC   -!- FUNCTION: Probable ion channel inhibitor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17476710}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:17476710}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 03 (juruin)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EU233838; ABY71657.1; -; mRNA.
DR   AlphaFoldDB; B1P1A7; -.
DR   SMR; B1P1A7; -.
DR   ArachnoServer; AS000787; U3-theraphotoxin-Cg1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..48
FT                   /evidence="ECO:0000269|PubMed:17476710"
FT                   /id="PRO_0000398502"
FT   PEPTIDE         49..87
FT                   /note="U3-theraphotoxin-Cg1b"
FT                   /evidence="ECO:0000269|PubMed:17476710"
FT                   /id="PRO_0000398503"
FT   DISULFID        52..65
FT                   /evidence="ECO:0000250|UniProtKB:P85504"
FT   DISULFID        56..79
FT                   /evidence="ECO:0000250|UniProtKB:P85504"
FT   DISULFID        73..84
FT                   /evidence="ECO:0000250|UniProtKB:P85504"
SQ   SEQUENCE   87 AA;  9668 MW;  9B8675C43D07CCA1 CRC64;
     MRTFTLIAIL TCAVLVIFHV SAAEELEAQD VIQPEDIFTG VATLEEDRIF ECSFSCDIKK
     NGKPCKGAGE KKCSGGWRCK MNFCVKF