ID   JZT48_CHIGU             Reviewed;          87 AA.
AC   B1P1A9;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=U3-theraphotoxin-Cg1c {ECO:0000305};
DE            Short=U3-TRTX-Cg1c {ECO:0000305};
DE   AltName: Full=Jingzhaotoxin-48 {ECO:0000305};
DE            Short=JZTX-48 {ECO:0000312|EMBL:ABY71659.1};
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
CC   -!- FUNCTION: Probable ion channel inhibitor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:B1P1A6}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 03 (juruin)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EU233840; ABY71659.1; -; mRNA.
DR   AlphaFoldDB; B1P1A9; -.
DR   SMR; B1P1A9; -.
DR   ArachnoServer; AS000789; U3-theraphotoxin-Cg1c.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..51
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000398506"
FT   PEPTIDE         52..87
FT                   /note="U3-theraphotoxin-Cg1c"
FT                   /evidence="ECO:0000250|UniProtKB:B1P1A6"
FT                   /id="PRO_0000398507"
FT   DISULFID        52..65
FT                   /evidence="ECO:0000250|UniProtKB:P85504"
FT   DISULFID        56..79
FT                   /evidence="ECO:0000250|UniProtKB:P85504"
FT   DISULFID        73..84
FT                   /evidence="ECO:0000250|UniProtKB:P85504"
SQ   SEQUENCE   87 AA;  9641 MW;  9B8675C43D11A071 CRC64;
     MRTFTLIAIL TCAVLVIFHV SAAEELEAQD VIQPEDIFTG VATLEEDRIF ECSFSCDIKK
     NGKPCTGAGE KKCSGGWRCK MNFCVKF