ID   JZT4A_CHIGU             Reviewed;          63 AA.
AC   B1P1D5;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Kappa-theraphotoxin-Cg3a 1;
DE            Short=Kappa-TRTX-Cg3a;
DE   AltName: Full=Jingzhaotoxin-4;
DE            Short=JZTX-4;
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
CC   -!- FUNCTION: Gating modifier of Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3
CC       channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 44 (Jztx-4)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EU233866; ABY71685.1; -; mRNA.
DR   AlphaFoldDB; B1P1D5; -.
DR   BMRB; B1P1D5; -.
DR   SMR; B1P1D5; -.
DR   ArachnoServer; AS000814; kappa-theraphotoxin-Cg3a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   Pfam; PF07740; Toxin_12; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Knottin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..29
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000398394"
FT   PEPTIDE         30..63
FT                   /note="Kappa-theraphotoxin-Cg3a 1"
FT                   /id="PRO_0000398395"
FT   DISULFID        31..46
FT                   /evidence="ECO:0000250|UniProtKB:P62520"
FT   DISULFID        38..51
FT                   /evidence="ECO:0000250|UniProtKB:P62520"
FT   DISULFID        45..58
FT                   /evidence="ECO:0000250|UniProtKB:P62520"
SQ   SEQUENCE   63 AA;  6842 MW;  49FFA6840F9E4ED2 CRC64;
     MKNTSILFIL GLALLLVLAF EVQVGESDGE CGGFWWKCGS GKPACCPKYV CSPKWGLCNF
     PMP