ID   JZT69_CHIGU             Reviewed;         124 AA.
AC   B1P1I9;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=U33-theraphotoxin-Cg1a {ECO:0000305};
DE            Short=U33-TRTX-Cg1a {ECO:0000305};
DE   AltName: Full=Jingzhaotoxin-69 {ECO:0000303|PubMed:18581053};
DE            Short=JZTX-69 {ECO:0000303|PubMed:18581053};
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:18581053}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:B1P1J0}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 32 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU233920; ABY71739.1; -; mRNA.
DR   AlphaFoldDB; B1P1I9; -.
DR   SMR; B1P1I9; -.
DR   TCDB; 8.B.10.1.3; the psalmotoxin-1 (pctx1) family.
DR   ArachnoServer; AS000868; U33-theraphotoxin-Cg1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..124
FT                   /note="U33-theraphotoxin-Cg1a"
FT                   /evidence="ECO:0000305|PubMed:18581053"
FT                   /id="PRO_0000398552"
FT   REGION          93..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        26..37
FT                   /evidence="ECO:0000250|UniProtKB:B1P1J0"
FT   DISULFID        31..51
FT                   /evidence="ECO:0000250|UniProtKB:B1P1J0"
FT   DISULFID        36..75
FT                   /evidence="ECO:0000250|UniProtKB:B1P1J0"
FT   DISULFID        61..83
FT                   /evidence="ECO:0000250|UniProtKB:B1P1J0"
FT   DISULFID        77..94
FT                   /evidence="ECO:0000250|UniProtKB:B1P1J0"
SQ   SEQUENCE   124 AA;  13358 MW;  5569A62415A53D9B CRC64;
     MKFAVAIAFT LLVCVFAQEE EEPVTCGGKQ CKPNSCCVQN SHGKGKDSPR CHPLGKLNNP
     CEVEPNENGI YSQHCPCGEG LSCTKVGEPN KLRCQEESGK SDKSKESQGS DESEESEESK
     ESCG