ID   JZT71_CHIGU             Reviewed;         124 AA.
AC   B1P1J0;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=U33-theraphotoxin-Cg1b {ECO:0000305};
DE            Short=U33-TRTX-Cg1b {ECO:0000305};
DE   AltName: Full=Jingzhaotoxin-71 {ECO:0000303|PubMed:18581053};
DE            Short=JZTX-71 {ECO:0000303|PubMed:18581053};
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:18581053}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000312|PDB:2N8K}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 32 family. {ECO:0000305}.
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DR   EMBL; EU233921; ABY71740.1; -; mRNA.
DR   PDB; 2N8K; NMR; -; A=24-98.
DR   PDBsum; 2N8K; -.
DR   AlphaFoldDB; B1P1J0; -.
DR   BMRB; B1P1J0; -.
DR   SMR; B1P1J0; -.
DR   ArachnoServer; AS000869; U33-theraphotoxin-Cg1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         18..124
FT                   /note="U33-theraphotoxin-Cg1b"
FT                   /evidence="ECO:0000305|PubMed:18581053"
FT                   /id="PRO_0000398554"
FT   REGION          93..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        26..37
FT                   /evidence="ECO:0007744|PDB:2N8K"
FT   DISULFID        31..51
FT                   /evidence="ECO:0007744|PDB:2N8K"
FT   DISULFID        36..75
FT                   /evidence="ECO:0007744|PDB:2N8K"
FT   DISULFID        61..83
FT                   /evidence="ECO:0007744|PDB:2N8K"
FT   DISULFID        77..94
FT                   /evidence="ECO:0007744|PDB:2N8K"
FT   STRAND          24..26
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          29..31
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          33..38
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          43..46
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          50..53
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          67..69
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          71..74
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          79..85
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          87..90
FT                   /evidence="ECO:0007829|PDB:2N8K"
FT   STRAND          92..96
FT                   /evidence="ECO:0007829|PDB:2N8K"
SQ   SEQUENCE   124 AA;  13270 MW;  5572A62415A53EFB CRC64;
     MKFAVAIAFT LLVCVFAQEE EEPVTCGGKQ CKPNSCCVQN SHGKGKDSPR CHPLGKLNNP
     CEVEPNENGI YSQHCPCGEG LSCTKVGEPN KLRCQEESGK SDKSKESQGS DESEESEGSK
     ESSG