JZT74_CHIGU
ID JZT74_CHIGU Reviewed; 134 AA.
AC B1P1J2;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=U34-theraphotoxin-Cg1a {ECO:0000305};
DE Short=U34-TRTX-Cg1a {ECO:0000305};
DE AltName: Full=Jingzhaotoxin-74 {ECO:0000303|PubMed:18581053};
DE Short=JZTX-74 {ECO:0000303|PubMed:18581053};
DE Flags: Precursor;
OS Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS jingzhao).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Chilobrachys.
OX NCBI_TaxID=278060;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT Chilobrachys jingzhao.";
RL Cell. Mol. Life Sci. 65:2431-2444(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:18581053}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC {ECO:0000250|UniProtKB:B1P1J0}.
CC -!- SIMILARITY: Belongs to the neurotoxin 32 family. {ECO:0000305}.
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DR EMBL; EU233923; ABY71742.1; -; mRNA.
DR AlphaFoldDB; B1P1J2; -.
DR SMR; B1P1J2; -.
DR TCDB; 8.B.10.1.2; the psalmotoxin-1 (pctx1) family.
DR ArachnoServer; AS000871; U34-theraphotoxin-Cg1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PEPTIDE 20..134
FT /note="U34-theraphotoxin-Cg1a"
FT /evidence="ECO:0000305|PubMed:18581053"
FT /id="PRO_0000398558"
FT REGION 97..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 24..35
FT /evidence="ECO:0000250|UniProtKB:B1P1J0"
FT DISULFID 29..53
FT /evidence="ECO:0000250|UniProtKB:B1P1J0"
FT DISULFID 63..84
FT /evidence="ECO:0000250|UniProtKB:B1P1J0"
SQ SEQUENCE 134 AA; 14922 MW; 5A6CF6443A20B2DF CRC64;
MKLAVVFLLT TVVFTLAQSQ CENCADLQCN STVHCCLVST VRLPRWKREI SRCGRLAIRR
WRCEEPNSNG IYNRNCPCVP GLECREFRRG RRICLPEQSS TSTSSTQGPI TSSTVTTQSE
ATTETETTTA AEGK