K0040_HUMAN
ID K0040_HUMAN Reviewed; 99 AA.
AC Q15053; A8K9H6; J3QR46; Q2NKQ0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Uncharacterized protein KIAA0040;
GN Name=KIAA0040;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=7584026; DOI=10.1093/dnares/1.1.27;
RA Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S.,
RA Nagase T., Seki N., Ishikawa K., Tabata S.;
RT "Prediction of the coding sequences of unidentified human genes. I. The
RT coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of
RT randomly sampled cDNA clones from human immature myeloid cell line KG-1.";
RL DNA Res. 1:27-35(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Rhodes S.;
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA05022.2; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=BAF85380.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=CAB42560.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=CAB42561.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=EAW90987.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; D25539; BAA05022.2; ALT_SEQ; mRNA.
DR EMBL; AK292691; BAF85380.1; ALT_SEQ; mRNA.
DR EMBL; AL049799; CAB42560.1; ALT_SEQ; mRNA.
DR EMBL; AL049800; CAB42561.1; ALT_SEQ; mRNA.
DR EMBL; Z99715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL008626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW90987.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS86034.1; -.
DR RefSeq; NP_001156365.1; NM_001162893.1.
DR RefSeq; NP_001156366.1; NM_001162894.1.
DR RefSeq; NP_001156367.1; NM_001162895.1.
DR RefSeq; NP_001306159.1; NM_001319230.1.
DR RefSeq; NP_001306160.1; NM_001319231.1.
DR RefSeq; NP_055471.2; NM_014656.2.
DR RefSeq; XP_016858398.1; XM_017002909.1.
DR RefSeq; XP_016858399.1; XM_017002910.1.
DR RefSeq; XP_016858400.1; XM_017002911.1.
DR AlphaFoldDB; Q15053; -.
DR BioGRID; 115029; 5.
DR STRING; 9606.ENSP00000464040; -.
DR BioMuta; KIAA0040; -.
DR MassIVE; Q15053; -.
DR PaxDb; Q15053; -.
DR PeptideAtlas; Q15053; -.
DR PRIDE; Q15053; -.
DR Antibodypedia; 63336; 21 antibodies from 9 providers.
DR DNASU; 9674; -.
DR Ensembl; ENST00000423313.6; ENSP00000462172.1; ENSG00000235750.10.
DR Ensembl; ENST00000444639.5; ENSP00000463734.1; ENSG00000235750.10.
DR Ensembl; ENST00000545251.6; ENSP00000464040.1; ENSG00000235750.10.
DR GeneID; 9674; -.
DR KEGG; hsa:9674; -.
DR MANE-Select; ENST00000423313.6; ENSP00000462172.1; NM_014656.3; NP_055471.2.
DR UCSC; uc001gkn.4; human.
DR UCSC; uc057nmk.1; human.
DR CTD; 9674; -.
DR DisGeNET; 9674; -.
DR GeneCards; KIAA0040; -.
DR HGNC; HGNC:28950; KIAA0040.
DR HPA; ENSG00000235750; Tissue enhanced (placenta).
DR MIM; 616696; gene.
DR neXtProt; NX_Q15053; -.
DR OpenTargets; ENSG00000235750; -.
DR PharmGKB; PA128394552; -.
DR VEuPathDB; HostDB:ENSG00000235750; -.
DR eggNOG; ENOG502SAYZ; Eukaryota.
DR GeneTree; ENSGT00620000089392; -.
DR HOGENOM; CLU_1712658_0_0_1; -.
DR OMA; KGEEDLW; -.
DR OrthoDB; 1603880at2759; -.
DR PathwayCommons; Q15053; -.
DR SignaLink; Q15053; -.
DR BioGRID-ORCS; 9674; 5 hits in 213 CRISPR screens.
DR ChiTaRS; KIAA0040; human.
DR GenomeRNAi; 9674; -.
DR Pharos; Q15053; Tdark.
DR PRO; PR:Q15053; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q15053; protein.
DR Bgee; ENSG00000235750; Expressed in right lung and 163 other tissues.
DR ExpressionAtlas; Q15053; baseline and differential.
DR Genevisible; Q15053; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039964; KIAA0040-like.
DR PANTHER; PTHR40382; PTHR40382; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..99
FT /note="Uncharacterized protein KIAA0040"
FT /id="PRO_0000444986"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 54..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 65..67
FT /note="Missing (in Ref. 1; BAA05022 and 2; BAF85380)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 99 AA; 11435 MW; 1BB0786878ED0A28 CRC64;
MERISAFFSS IWDTILTKHQ EGIYNTICLG VLLGLPLLVI ITLLFICCHC CWSPPGKRGQ
QPEKNKKKKK KKKKKDEEDL WISAQPKLLQ MEKRPSLPV
