K0100_HUMAN
ID K0100_HUMAN Reviewed; 2235 AA.
AC Q14667; A6NCX3; Q3SYN5; Q49A07; Q5H9T4; Q6WG74; Q6ZP51; Q96HH8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Protein KIAA0100;
DE AltName: Full=Antigen MLAA-22;
DE AltName: Full=Breast cancer-overexpressed gene 1 protein;
DE Flags: Precursor;
GN Name=KIAA0100; Synonyms=BCOX1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND TISSUE SPECIFICITY.
RC TISSUE=Mammary cancer;
RX PubMed=16289875; DOI=10.1016/j.bbagen.2005.09.017;
RA Song J., Yang W., Shih I.-M., Zhang Z., Bai J.;
RT "Identification of BCOX1, a novel gene overexpressed in breast cancer.";
RL Biochim. Biophys. Acta 1760:62-69(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=7788527; DOI=10.1093/dnares/2.1.37;
RA Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S.,
RA Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. III. The
RT coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of
RT cDNA clones from human cell line KG-1.";
RL DNA Res. 2:37-43(1995).
RN [3]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R., Nomura N.;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1866-2235 (ISOFORM 1).
RC TISSUE=Brain, Glioblastoma, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-528 (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1557-2198 (ISOFORM 1).
RC TISSUE=Monocytic leukemia;
RX PubMed=15755502; DOI=10.1016/j.leukres.2004.09.013;
RA Chen G., Zhang W.G., Cao X.M., Li F.Y., Liu X.P., Yao L.B.;
RT "Serological identification of immunogenic antigens in acute monocytic
RT leukemia.";
RL Leuk. Res. 29:503-509(2005).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1846, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1846; SER-2090 AND SER-2094,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in membrane trafficking.
CC {ECO:0000250|UniProtKB:K7VLR4}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q14667-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14667-2; Sequence=VSP_020321;
CC Name=3;
CC IsoId=Q14667-3; Sequence=VSP_020317, VSP_020322;
CC Name=4;
CC IsoId=Q14667-4; Sequence=VSP_020318, VSP_020319, VSP_020320;
CC -!- TISSUE SPECIFICITY: Expressed in pancreas, placenta and up-regulated in
CC breast carcinoma epithelial cells, ductal in situ carcinoma (DCIS),
CC invasive breast carcinoma (IBC) and metastatic breast carcinoma cells
CC (MET). {ECO:0000269|PubMed:16289875}.
CC -!- SIMILARITY: Belongs to the SABRE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ93061.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAQ93061.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC Sequence=BAC85274.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY943906; AAY19515.1; -; mRNA.
DR EMBL; D43947; BAA07891.3; -; mRNA.
DR EMBL; CR933634; CAI45940.1; -; mRNA.
DR EMBL; AC005726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008591; AAH08591.2; -; mRNA.
DR EMBL; BC048096; AAH48096.1; -; mRNA.
DR EMBL; BC103726; AAI03727.1; -; mRNA.
DR EMBL; AK130007; BAC85274.1; ALT_SEQ; mRNA.
DR EMBL; AY288965; AAQ93061.1; ALT_SEQ; mRNA.
DR CCDS; CCDS32595.1; -. [Q14667-1]
DR RefSeq; NP_055495.2; NM_014680.3. [Q14667-1]
DR AlphaFoldDB; Q14667; -.
DR BioGRID; 115055; 41.
DR IntAct; Q14667; 6.
DR STRING; 9606.ENSP00000436773; -.
DR GlyGen; Q14667; 1 site.
DR iPTMnet; Q14667; -.
DR MetOSite; Q14667; -.
DR PhosphoSitePlus; Q14667; -.
DR BioMuta; KIAA0100; -.
DR DMDM; 114149325; -.
DR EPD; Q14667; -.
DR jPOST; Q14667; -.
DR MassIVE; Q14667; -.
DR MaxQB; Q14667; -.
DR PaxDb; Q14667; -.
DR PeptideAtlas; Q14667; -.
DR PRIDE; Q14667; -.
DR ProteomicsDB; 60096; -. [Q14667-1]
DR ProteomicsDB; 60097; -. [Q14667-2]
DR ProteomicsDB; 60098; -. [Q14667-3]
DR ProteomicsDB; 60099; -. [Q14667-4]
DR Antibodypedia; 51190; 58 antibodies from 20 providers.
DR DNASU; 9703; -.
DR Ensembl; ENST00000528896.7; ENSP00000436773.2; ENSG00000007202.15. [Q14667-1]
DR GeneID; 9703; -.
DR KEGG; hsa:9703; -.
DR MANE-Select; ENST00000528896.7; ENSP00000436773.2; NM_014680.5; NP_055495.2.
DR UCSC; uc002hbu.4; human. [Q14667-1]
DR CTD; 9703; -.
DR DisGeNET; 9703; -.
DR GeneCards; KIAA0100; -.
DR HGNC; HGNC:28960; KIAA0100.
DR HPA; ENSG00000007202; Low tissue specificity.
DR MIM; 610664; gene.
DR neXtProt; NX_Q14667; -.
DR OpenTargets; ENSG00000007202; -.
DR PharmGKB; PA142671635; -.
DR VEuPathDB; HostDB:ENSG00000007202; -.
DR eggNOG; KOG1910; Eukaryota.
DR GeneTree; ENSGT00600000084481; -.
DR InParanoid; Q14667; -.
DR OMA; WHMTVTG; -.
DR OrthoDB; 26089at2759; -.
DR PhylomeDB; Q14667; -.
DR TreeFam; TF314307; -.
DR PathwayCommons; Q14667; -.
DR SignaLink; Q14667; -.
DR BioGRID-ORCS; 9703; 111 hits in 1087 CRISPR screens.
DR ChiTaRS; KIAA0100; human.
DR GenomeRNAi; 9703; -.
DR Pharos; Q14667; Tbio.
DR PRO; PR:Q14667; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q14667; protein.
DR Bgee; ENSG00000007202; Expressed in adrenal tissue and 192 other tissues.
DR ExpressionAtlas; Q14667; baseline and differential.
DR Genevisible; Q14667; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR045167; FMP27.
DR InterPro; IPR019443; FMP27_C.
DR InterPro; IPR019441; FMP27_GFWDK_dom.
DR InterPro; IPR019439; FMP27_N.
DR PANTHER; PTHR15678; PTHR15678; 1.
DR Pfam; PF10351; Apt1; 1.
DR Pfam; PF10344; Fmp27; 2.
DR Pfam; PF10347; Fmp27_GFWDK; 1.
DR SMART; SM01214; Fmp27_GFWDK; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Glycoprotein; Phosphoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..2235
FT /note="Protein KIAA0100"
FT /id="PRO_0000248587"
FT REGION 1495..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2074..2099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1813..1885
FT /evidence="ECO:0000255"
FT COMPBIAS 1511..1527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 563
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SYL3"
FT MOD_RES 1846
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 2090
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 2094
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 730
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..1846
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020317"
FT VAR_SEQ 1..143
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16289875"
FT /id="VSP_020318"
FT VAR_SEQ 339..365
FT /note="DGLLLSQSRQRIVCLNSLKASVQVTTI -> GSWVGVLVLSENGRTRYSLCS
FT CPIWSP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16289875"
FT /id="VSP_020319"
FT VAR_SEQ 366..2235
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16289875"
FT /id="VSP_020320"
FT VAR_SEQ 797..826
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_020321"
FT VAR_SEQ 1847..1848
FT /note="KN -> MI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020322"
FT VARIANT 986
FT /note="H -> Q (in dbSNP:rs16964472)"
FT /id="VAR_027352"
FT VARIANT 1516
FT /note="V -> G (in dbSNP:rs12602520)"
FT /id="VAR_027353"
FT VARIANT 2060
FT /note="R -> G (in dbSNP:rs16964462)"
FT /id="VAR_052706"
FT CONFLICT 77
FT /note="L -> P (in Ref. 4; CAI45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="G -> V (in Ref. 4; CAI45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 601
FT /note="T -> A (in Ref. 4; CAI45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 1264
FT /note="T -> A (in Ref. 4; CAI45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 1546
FT /note="F -> L (in Ref. 4; CAI45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 1573
FT /note="N -> H (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 1662
FT /note="Q -> E (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 1734
FT /note="L -> H (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 1764
FT /note="Missing (in Ref. 4; CAI45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 1830
FT /note="Q -> H (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 1838
FT /note="I -> T (in Ref. 4; CAI45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 1968
FT /note="V -> I (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 2018..2020
FT /note="THQ -> SHR (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 2034
FT /note="S -> N (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 2073
FT /note="P -> S (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 2094
FT /note="S -> L (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
FT CONFLICT 2185
FT /note="S -> P (in Ref. 8; AAQ93061)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2235 AA; 253700 MW; 15BCEB09FAEFD7E3 CRC64;
MPLFFSALLV LLLVALSALF LGRWLVVRLA TKWCQRKLQA ELKIGSFRFF WIQNVSLKFQ
QHQQTVEIDN LWISSKLLSH DLPHYVALCF GEVRIRTDLQ KVSDLSAPFS QSAGVDQKEL
SFSPSLLKIF CQLFSIHVDA INIMVLKVDT SESLWHIQIS RSRFLLDSDG KRLICEVSLC
KINSKVLKSG QLEDTCLVEL SLALDLCLKV GISSRHLTAI TVDVWTLHAE LHEGLFQSQL
LCQGPSLASK PVPCSEVTEN LVEPTLPGLF LLQQLPDQVK VKMENTSVVL SMNSQKRHLT
WTLKLLQFLY HRDEDQLPLR SFTANSDMAQ MSTELLLEDG LLLSQSRQRI VCLNSLKASV
QVTTIDLSAS LVLNTCIIHY RHQEFSHWLH LLALETQGSS SPVLKQRKKR TFPQILAPII
FSTSISNVNI SIQLGDTPPF ALGFNSISLD YQHLRPQSIH QRGVLTVDHL CWRVGSDSHI
QRAPHPPNMH VWGEALVLDS FTLQGSYNQP LGLSSTQSDT LFLDCTIRGL QVEASDTCAQ
CLSRILSLMG PQSGKSAVSR HSSFGESVSL LWKVDLKVED MNLFTLSALV GASEVRLDTL
TILGSAETST VGIQGLVLAL VKSVTEKMQP CCKAPDIPTP VLSLSMLSIT YHSSIRSLEV
QCGAGLTLLW SPPDHMYLYQ HVLATLQCRD LLRATVFPET VPSLALETSG TTSELEGRAP
EPLPPKRLLN LTLEVSTAKL TAFVAEDKFI TLAAESVSLS RHGGSLQAYC PELAAGFDGN
SIFNFKEVEV QLLPELEEMI LHRNPFPALQ TLRNRVWLLS FGSVSVEFPY QYDFSRTLDE
AVGVQKWLKG LHQGTRAWAS PSPVPLPPDL LLKVEHFSWV FLDDVFEVKL HDNYELMKDE
SKESAKRLQL LDAKVAALRK QHGELLPARK IEELYASLER KNIEIYIQRS RRLYGNTPMR
RALLTWSLAG LELVALADAS FHGPEHVVEQ VQELDPGSPF PPEGLDLVIQ WCRMLKCNVK
SFLVRIRDYP RYLFEIRDWR LMGRLVGTEQ SGQPCSRRRQ ILHLGLPWGN VAVERNMPPL
KFYHDFHSEI FQYTVVWGPC WDPAWTLIGQ CVDLLTKPSA DPSPPLPWWD KSRLLFHGDW
HMDIEQANLH QLATEDPYNT TENMHWEWSH LSFHWKPGQF VFKGDLDINV RTASKYDDCC
FLHLPDLCMT LDLQWLCHGN PHDHHSVTLR APEFLPEVPL GQLHDSYRAF RSENLNLSIK
MDLTRHSGTI SQPRILLYSS TLRWMQNFWA TWTSVTRPIC RGKLFNNLKP SKKKLGQHYK
QLSYTALFPQ LQVHYWASFA QQRGIQIECS QGHVFTRGTQ RLIPQAGTVM RRLISDWSVT
QMVSDLSQVT VHLMASPTEE NADHCLDPLV TKTHLLSLSS LTYQRHSNRT AEEELSARDG
DPTFHTHQLH LVDLRISWTT TNRDIAFGLY DGYKKAAVLK RNLSTEALKG LKIDPQMPAK
KPKRGVPTSA SAPPRVNTPS FSGQPDKGSS GGAYMLQKLI EETDRFVVFT EEESGMSDQL
CGIAACQTDD IYNRNCLIEL VNCQMVLRGA ETEGCVIVSA AKAQLLQCQH HPAWYGDTLK
QKTSWTCLLD GMQYFATTES SPTEQDGRQL WLEVKNIEEH RQRSLDSVQE LMESGQAVGG
MVTTTTDWNQ PAEAQQAQQV QRIISRCNCR MYYISYSHDI DPELATQIKP PEVLENQEKE
DLLKKQEGAV DTFTLIHHEL EISTNPAQYA MILDIVNNLL LHVEPKRKEH SEKKQRVRFQ
LEISSNPEEQ RSSILHLQEA VRQHVAQIRQ LEKQMYSIMK SLQDDSKNEN LLDLNQKLQL
QLNQEKANLQ LESEELNILI RCFKDFQLQR ANKMELRKQQ EDVSVVRRTE FYFAQARWRL
TEEDGQLGIA ELELQRFLYS KVNKSDDTAE HLLELGWFTM NNLLPNAVYK VVLRPQSSCQ
SGRQLALRLF SKVRPPVGGI SVKEHFEVNV VPLTIQLTHQ FFHRMMGFFF PGRSVEDDEV
GDEEDKSKLV TTGIPVVKPR QLIATDDAVP LGPGKGVAQG LTRSSGVRRS FRKSPEHPVD
DIDKMKERAA MNNSFIYIKI PQVPLCVSYK GEKNSVDWGD LNLVLPCLEY HNNTWTWLDF
AMAVKRDSRK ALVAQVIKEK LRLKSATGSE VRGKLETKSD LNMQQQEEEE KARLLIGLSV
GDKNPGKKSI FGRRK
