K0100_MOUSE
ID K0100_MOUSE Reviewed; 2234 AA.
AC Q5SYL3; Q3UE65; Q66JY1; Q6DIC4; Q80U77; Q8C1W6; Q8CE06; Q8CGE3; Q9CSS8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein KIAA0100;
DE Flags: Precursor;
GN Name=Kiaa0100;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Embryo, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 752-2234.
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in membrane trafficking.
CC {ECO:0000250|UniProtKB:K7VLR4}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SABRE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH80706.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAB28000.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK012059; BAB28000.1; ALT_INIT; mRNA.
DR EMBL; AK029280; BAC26370.1; -; mRNA.
DR EMBL; AK090138; BAC41111.1; -; mRNA.
DR EMBL; AK149719; BAE29046.1; -; mRNA.
DR EMBL; AL591070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040464; AAH40464.1; -; mRNA.
DR EMBL; BC075633; AAH75633.1; -; mRNA.
DR EMBL; BC080706; AAH80706.1; ALT_SEQ; mRNA.
DR EMBL; AK122206; BAC65488.1; -; mRNA.
DR CCDS; CCDS25097.1; -.
DR RefSeq; NP_001002004.2; NM_001002004.2.
DR AlphaFoldDB; Q5SYL3; -.
DR SMR; Q5SYL3; -.
DR BioGRID; 215404; 1.
DR STRING; 10090.ENSMUSP00000010421; -.
DR iPTMnet; Q5SYL3; -.
DR PhosphoSitePlus; Q5SYL3; -.
DR EPD; Q5SYL3; -.
DR MaxQB; Q5SYL3; -.
DR PaxDb; Q5SYL3; -.
DR PeptideAtlas; Q5SYL3; -.
DR PRIDE; Q5SYL3; -.
DR ProteomicsDB; 269150; -.
DR Antibodypedia; 51190; 58 antibodies from 20 providers.
DR Ensembl; ENSMUST00000010421; ENSMUSP00000010421; ENSMUSG00000010277.
DR GeneID; 72503; -.
DR KEGG; mmu:72503; -.
DR UCSC; uc007kir.2; mouse.
DR MGI; MGI:1919753; 2610507B11Rik.
DR VEuPathDB; HostDB:ENSMUSG00000010277; -.
DR eggNOG; KOG1910; Eukaryota.
DR GeneTree; ENSGT00600000084481; -.
DR HOGENOM; CLU_000926_1_0_1; -.
DR InParanoid; Q5SYL3; -.
DR OMA; WHMTVTG; -.
DR OrthoDB; 26089at2759; -.
DR PhylomeDB; Q5SYL3; -.
DR TreeFam; TF314307; -.
DR BioGRID-ORCS; 72503; 10 hits in 75 CRISPR screens.
DR ChiTaRS; 2610507B11Rik; mouse.
DR PRO; PR:Q5SYL3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SYL3; protein.
DR Bgee; ENSMUSG00000010277; Expressed in vestibular membrane of cochlear duct and 281 other tissues.
DR ExpressionAtlas; Q5SYL3; baseline and differential.
DR Genevisible; Q5SYL3; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR045167; FMP27.
DR InterPro; IPR019443; FMP27_C.
DR InterPro; IPR019441; FMP27_GFWDK_dom.
DR InterPro; IPR019439; FMP27_N.
DR PANTHER; PTHR15678; PTHR15678; 1.
DR Pfam; PF10351; Apt1; 1.
DR Pfam; PF10344; Fmp27; 2.
DR Pfam; PF10347; Fmp27_GFWDK; 1.
DR SMART; SM01214; Fmp27_GFWDK; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..2234
FT /note="Protein KIAA0100"
FT /id="PRO_0000248588"
FT REGION 1496..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1814..1885
FT /evidence="ECO:0000255"
FT MOD_RES 563
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1846
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14667"
FT MOD_RES 2090
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14667"
FT CONFLICT 68
FT /note="I -> F (in Ref. 3; AAH75633)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="K -> E (in Ref. 1; BAC41111)"
FT /evidence="ECO:0000305"
FT CONFLICT 1416
FT /note="L -> F (in Ref. 1; BAC26370)"
FT /evidence="ECO:0000305"
FT CONFLICT 1536
FT /note="L -> F (in Ref. 3; AAH75633)"
FT /evidence="ECO:0000305"
FT CONFLICT 1832
FT /note="E -> G (in Ref. 1; BAC41111)"
FT /evidence="ECO:0000305"
FT CONFLICT 2129
FT /note="Y -> H (in Ref. 3; AAH75633)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2234 AA; 254469 MW; 35614F3B4DD28A7B CRC64;
MPLFLSALLV LLLVALSALF LGRWLVVRLA TRWCQRKLQA ELKIGSFRFF WIQNVSLKFQ
QHQQTVEIDN LWISSKLLSH DLPNYVALCF GEVRIRTDLQ KVSSLSAPFS QNTEVEQKEL
SLSPSLLKIF CQLFSIHVDA INIMVLKVAT SESLWHIQIS RSRFLLDSDG KSLICKVNLS
KINSKVLKSG QLEDTCLVEL SLALDLRLQV SVSSWHLTAV TVDVWTLHAE LHEGLFHSQL
LCHAPGRISK SVSCSDLTEN FAEPTLPGLY LLQRLPDQVK VKMENTSVVL SMNSQKRHLT
WTLKLLHFLY HRDEDQLPLR SFTANYDMAQ MSTELLLEDG LLLSQSRQRI VCLNSLKANV
QVTTIDLSAS LVLNTCIIHY RHQEFSHWLL MLALETQGAS SPDLKQRKKR TFPQILAPII
FSTSVSNVSI SIQLGDTPPF ALGFNSISLD YQHLRPQSIH QRAVLTVDHL CWRVGSDSHI
QRAPHPPNMH VWGEALVLDS FTLQGSYNQP LGLSSTQSNT LFLDCTIRGL QVEISDICAQ
CLSRVLSLVI PQSERSAVSR KSSLGESVTL LWKVDLKVED MNLFTLSALV GASELRLDTL
TVLGSAETST VGIQGLVLAL VKSVTEKMQP CCKAPDIPTP VLGLSMLSLT YHSSIRSLEV
QCGAGLTLLW SPPDHMYLYQ HVRATLQCRD LLRATVFPEI IESHSLNTPQ STWEPEDHLP
ESSLPRRLLT LTLEVSTAKL TAFVAEDKFI TLAAESVSLN RHGGSLQAYC PELAAGFDGN
SIFNLKEVEV QLLPELEEMI LHRNPFPALQ TLRNRVWLLS LGSVSVEFPY QYDFSRTLDE
AVGVQKWLKG LHRGTHAWAS PSPAPLPPDL LLKVQHFSWV FLDDIFEVKL HDNYELMKDE
SKESAKRLQL LDAKVAALRK QHGELLPARK IEELYASLER KNIEIYIQRS RRLYGNTPMR
RALLTWSLAG LELVALADAS FHGPEHVIEQ VRELDPGSPF PAEGMDLVTQ WCRMLKCNVK
TFLVRIRDYP RYLFEIRDWR LMGRLAGTEQ SGQPCSRRRQ ILHLGLPWGN VAVERNMPPL
KFYHDFHSEI FQYTVVWGPC WDPAWTLIGQ CVDLLTKPSA DPSPPLPWWD KSRLLFHGDW
HMDIEQANLH QLATEDPYNT TENMHWEWSH LSFHWKPGQF VFRGDLDVNV RTASKYDDCC
FLHLPDLCMT LDLQWLCHGN PHDHHSVTLR APEFLPEVPL GQLHDSYRAF RSENLNLSIK
MDLTRHSGTI SQPRILVYSS TLRWMQNFWA TWTSITRPIC RGKLFNNLKP SKKKLGQHYK
QLSYTALFPQ LQVHYWASFA QQRGIQIECS QGHVFTRGTQ RLIPQAGTVM RRLISEWSVT
QMVSDLSQVT VHLMASPTEE NADHCLDPLI TKTHLLSLSS LTYQRHSNRT TEEELSARDG
DPAFHTHQLY LVDLRISWTT TNRDIAFGLY DGYKKAAVLK RNLSTEALKG LKIDPQMSAK
KPKRGIPPSA QVPPHVSTPS FSGRPDKGSS GGAYMLQKLI EETDRFVVFT EEESGMSDQL
CGIAACQTDD IYNRNCLIEL VNCQMVLRGA ETEGCVIVSA AKAQLLQCQH HPAWYGDTLK
QKTSWTCLLD GMQYFATTES SPTEQDGRQL WLEVKNIEEH RERSLDSVQE LMESGQAVGG
MVTTTTDWNQ PAEAQQAQQV QRIISRCNCR MYYISYSHDI DPELATQIKP PEVHENQEKE
DLLKKQEGAV DTFTLIHHEL EISTNPAQYA MILDIVNNLL LHVEPKRKEH SEKKQRVRFQ
LEISSNPEEQ RSSILHLQEA VRQHVAQIRH LEKQMYSIMK SLQDDSKNEN LLDLNQKLQL
QLNQEKANLQ LESEELNILI RCFKDFQLQR ANKMELRKQQ EDVSVVRRTE FYFAQARWRL
TEEDGQLGIA ELELQRFLYS KVNKSDDTAE HLLELGWFTM NNLLPNAIYK VVLRPQSSCQ
SGRQLALRLF SKVRPPVGGI SVKEHFEVNV VPLTIQLSHR FFHRMMGFFF PGRNVEDDEV
GDEEDKSKLV TTGIPVVKPR QLIATDDAVP LGSGKGVAQG LTRSSGVRRS FRKLPEHPVD
DIDKMKERAA MNNSFIYIKI PQVPLCVSYK GEKNSVDWGD LNLVLPCLEY HNNTWTWLDF
AMAVKRDSRK ALVAQVIKEK LRLKPATGSE VRGKLETKCD LNMQQQEEEK ARLLIGLSVG
DKNPGKKSIF GRRK
