K0232_HUMAN
ID K0232_HUMAN Reviewed; 1395 AA.
AC Q92628; A7E2D2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 5.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Uncharacterized protein KIAA0232;
GN Name=KIAA0232;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. VI. The
RT coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of
RT cDNA clones from cell line KG-1 and brain.";
RL DNA Res. 3:321-329(1996).
RN [2]
RP SEQUENCE REVISION TO 535.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-814; SER-1080 AND SER-1338,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13221.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D86985; BAA13221.3; ALT_INIT; mRNA.
DR EMBL; AC106045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC150286; AAI50287.1; -; mRNA.
DR CCDS; CCDS43209.1; -.
DR RefSeq; NP_001094060.1; NM_001100590.1.
DR RefSeq; NP_055558.2; NM_014743.2.
DR AlphaFoldDB; Q92628; -.
DR BioGRID; 115122; 73.
DR IntAct; Q92628; 31.
DR MINT; Q92628; -.
DR STRING; 9606.ENSP00000303928; -.
DR GlyConnect; 2088; 3 N-Linked glycans (1 site).
DR GlyGen; Q92628; 2 sites, 6 N-linked glycans (1 site), 1 O-linked glycan (1 site).
DR iPTMnet; Q92628; -.
DR PhosphoSitePlus; Q92628; -.
DR BioMuta; KIAA0232; -.
DR DMDM; 296439501; -.
DR EPD; Q92628; -.
DR jPOST; Q92628; -.
DR MassIVE; Q92628; -.
DR MaxQB; Q92628; -.
DR PaxDb; Q92628; -.
DR PeptideAtlas; Q92628; -.
DR PRIDE; Q92628; -.
DR ProteomicsDB; 75383; -.
DR Antibodypedia; 51996; 20 antibodies from 7 providers.
DR DNASU; 9778; -.
DR Ensembl; ENST00000307659.6; ENSP00000303928.5; ENSG00000170871.12.
DR Ensembl; ENST00000425103.5; ENSP00000413739.1; ENSG00000170871.12.
DR GeneID; 9778; -.
DR KEGG; hsa:9778; -.
DR MANE-Select; ENST00000307659.6; ENSP00000303928.5; NM_014743.3; NP_055558.2.
DR UCSC; uc003gjq.5; human.
DR CTD; 9778; -.
DR DisGeNET; 9778; -.
DR GeneCards; KIAA0232; -.
DR HGNC; HGNC:28992; KIAA0232.
DR HPA; ENSG00000170871; Low tissue specificity.
DR MIM; 619237; gene.
DR neXtProt; NX_Q92628; -.
DR OpenTargets; ENSG00000170871; -.
DR PharmGKB; PA162392816; -.
DR VEuPathDB; HostDB:ENSG00000170871; -.
DR eggNOG; ENOG502QQF7; Eukaryota.
DR GeneTree; ENSGT00390000018549; -.
DR HOGENOM; CLU_005177_0_0_1; -.
DR InParanoid; Q92628; -.
DR OMA; SNGFRRK; -.
DR OrthoDB; 60733at2759; -.
DR PhylomeDB; Q92628; -.
DR TreeFam; TF328400; -.
DR PathwayCommons; Q92628; -.
DR SignaLink; Q92628; -.
DR BioGRID-ORCS; 9778; 11 hits in 1081 CRISPR screens.
DR ChiTaRS; KIAA0232; human.
DR GenomeRNAi; 9778; -.
DR Pharos; Q92628; Tdark.
DR PRO; PR:Q92628; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q92628; protein.
DR Bgee; ENSG00000170871; Expressed in Brodmann (1909) area 23 and 210 other tissues.
DR ExpressionAtlas; Q92628; baseline and differential.
DR Genevisible; Q92628; HS.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR InterPro; IPR027871; DUF4603.
DR PANTHER; PTHR17611; PTHR17611; 1.
DR Pfam; PF15376; DUF4603; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome.
FT CHAIN 1..1395
FT /note="Uncharacterized protein KIAA0232"
FT /id="PRO_0000050738"
FT REGION 146..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1110..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 89..96
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT MOD_RES 814
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1080
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1194
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U59"
FT MOD_RES 1338
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CONFLICT 535
FT /note="N -> K (in Ref. 1; BAA13221 and 4; AAI50287)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1395 AA; 154789 MW; 3667D0D816A51F35 CRC64;
MYPICTVVVD GLPSESSSSS YPGPVSVSEM SLLHALGPVQ TWLGQELEKC GIDAMIYTRY
VLSLLLHDSY DYDLQEQEND IFLGWEKGAY KKWGKSKKKC SDLTLEEMKK QAAVQCLRSA
SDESSGIETL VEELCSRLKD LQSKQEEKIH KKLEGSPSPE AELSPPAKDQ VEMYYEAFPP
LSEKPVCLQE IMTVWNKSKV CSYSSSSSSS TAPPASTDTS SPKDCNSESE VTKERSSEVP
TTVHEKTQSK SKNEKENKFS NGTIEEKPAL YKKQIRHKPE GKIRPRSWSS GSSEAGSSSS
GNQGELKASM KYVKVRHKAR EIRNKKGRNG QSRLSLKHGE KAERNIHTGS SSSSSSGSVK
QLCKRGKRPL KEIGRKDPGS TEGKDLYMEN RKDTEYKEEP LWYTEPIAEY FVPLSRKSKL
ETTYRNRQDT SDLTSEAVEE LSESVHGLCI SNNNLHKTYL AAGTFIDGHF VEMPAVINED
IDLTGTSLCS LPEDNKYLDD IHLSELTHFY EVDIDQSMLD PGASETMQGE SRILNMIRQK
SKENTDFEAE CCIVLDGMEL QGERAIWTDS TSSVGAEGLF LQDLGNLAQF WECCSSSSGD
ADGESFGGDS PVRLSPILDS TVLNSHLLAG NQELFSDINE GSGINSCFSV FEVQCSNSVL
PFSFETLNLG NENTDSSANM LGKTQSRLLI WTKNSAFEEN EHCSNLSTRT CSPWSHSEET
RSDNETLNIQ FEESTQFNAE DINYVVPRVS SNYVDEELLD FLQDETCQQN SRTLGEIPTL
VFKKTSKLES VCGIQLEQKT ENKNFETTQV CNESPHGDGY SSGVIKDIWT KMADTNSVAT
VEIERTDAEL FSADVNNYCC CLDAEAELET LQEPDKAVRR SEYHLWEGQK ESLEKRAFAS
SELSNVDGGD YTTPSKPWDV AQDKENTFIL GGVYGELKTF NSDGEWAVVP PSHTKGSLLQ
CAASDVVTIA GTDVFMTPGN SFAPGHRQLW KPFVSFEQND QPKSGENGLN KGFSFIFHED
LLGACGNFQV EDPGLEYSFS SFDLSNPFSQ VLHVECSFEP EGIASFSPSF KPKSILCSDS
DSEVFHPRIC GVDRTQYRAI RISPRTHFRP ISASELSPGG GSESEFESEK DEANIPIPSQ
VDIFEDPQAD LKPLEEDAEK EGHYYGKSEL ESGKFLPRLK KSGMEKSAQT SLDSQEESTG
ILSVGKQNQC LECSMNESLE IDLESSEANC KIMAQCEEEI NNFCGCKAGC QFPAYEDNPV
SSGQLEEFPV LNTDIQGMNR SQEKQTWWEK ALYSPLFPAS ECEECYTNAK GESGLEEYPD
AKETPSNEER LLDFNRVSSV YEARCTGERD SGAKSDGFRG KMCSSASSTS EETGSEGGGE
WVGPSEEELF SRTHL
