K0232_MOUSE
ID K0232_MOUSE Reviewed; 1396 AA.
AC Q80U59; Q3U6T9; Q3UTK1; Q3UYU6; Q504Z4; Q80XC4; Q8BJI7; Q8BZV3;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Uncharacterized protein KIAA0232;
GN Name=Kiaa0232; Synonyms=D5Ertd579e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-1276 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Brain cortex, Colon, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 347-1396 (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-1396 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1197, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q80U59-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80U59-2; Sequence=VSP_021649, VSP_021650;
CC Name=3;
CC IsoId=Q80U59-3; Sequence=VSP_021647, VSP_021648;
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DR EMBL; AK033480; BAC28310.2; -; mRNA.
DR EMBL; AK083736; BAC39009.1; -; mRNA.
DR EMBL; AK134363; BAE22115.1; -; mRNA.
DR EMBL; AK139370; BAE23979.1; -; mRNA.
DR EMBL; AK152987; BAE31635.1; -; mRNA.
DR EMBL; CAAA01061871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAAA01088923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC051182; AAH51182.1; -; mRNA.
DR EMBL; BC094673; AAH94673.1; -; mRNA.
DR EMBL; AK122224; BAC65506.1; -; mRNA.
DR CCDS; CCDS39073.2; -. [Q80U59-1]
DR RefSeq; NP_001074701.3; NM_001081232.3.
DR AlphaFoldDB; Q80U59; -.
DR STRING; 10090.ENSMUSP00000031091; -.
DR iPTMnet; Q80U59; -.
DR PhosphoSitePlus; Q80U59; -.
DR jPOST; Q80U59; -.
DR PaxDb; Q80U59; -.
DR PRIDE; Q80U59; -.
DR ProteomicsDB; 301704; -. [Q80U59-1]
DR ProteomicsDB; 301705; -. [Q80U59-2]
DR Antibodypedia; 51996; 20 antibodies from 7 providers.
DR Ensembl; ENSMUST00000140653; ENSMUSP00000144240; ENSMUSG00000029190. [Q80U59-3]
DR GeneID; 320661; -.
DR KEGG; mmu:320661; -.
DR UCSC; uc029vhd.2; mouse. [Q80U59-2]
DR CTD; 320661; -.
DR MGI; MGI:1261849; D5Ertd579e.
DR VEuPathDB; HostDB:ENSMUSG00000029190; -.
DR eggNOG; ENOG502QQF7; Eukaryota.
DR GeneTree; ENSGT00390000018549; -.
DR InParanoid; Q80U59; -.
DR OrthoDB; 60733at2759; -.
DR PhylomeDB; Q80U59; -.
DR BioGRID-ORCS; 320661; 1 hit in 66 CRISPR screens.
DR ChiTaRS; D5Ertd579e; mouse.
DR PRO; PR:Q80U59; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q80U59; protein.
DR Bgee; ENSMUSG00000029190; Expressed in caudate-putamen and 223 other tissues.
DR ExpressionAtlas; Q80U59; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR InterPro; IPR027871; DUF4603.
DR PANTHER; PTHR17611; PTHR17611; 1.
DR Pfam; PF15376; DUF4603; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Nucleotide-binding; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1396
FT /note="Uncharacterized protein KIAA0232"
FT /id="PRO_0000261138"
FT REGION 146..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..334
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 88..95
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT MOD_RES 817
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92628"
FT MOD_RES 1083
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92628"
FT MOD_RES 1197
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1339
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92628"
FT VAR_SEQ 78..83
FT /note="ENDILS -> VGIDAC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021647"
FT VAR_SEQ 84..1396
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021648"
FT VAR_SEQ 174..204
FT /note="YEAFPPLSEKPVCLQEIMTVWNKSKPCSYSS -> VRLLSLKYVLLKPVSLL
FT PHGFHFCHLYDFLI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021649"
FT VAR_SEQ 205..1396
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021650"
FT CONFLICT 107
FT /note="M -> V (in Ref. 1; BAC39009)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="S -> C (in Ref. 1; BAC28310)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="I -> F (in Ref. 1; BAE22115)"
FT /evidence="ECO:0000305"
FT CONFLICT 1007
FT /note="R -> S (in Ref. 1; BAE23979 and 3; AAH94673)"
FT /evidence="ECO:0000305"
FT CONFLICT 1143
FT /note="H -> Q (in Ref. 1; BAE23979 and 3; AAH94673)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1396 AA; 154778 MW; FEF8C1172D85B0DB CRC64;
MRPVCTVVVD GLPSESTSSS YPGPVSVSDM SLLHALGPVQ TWLGQELEKC GIDAMIYSRY
ILSLLLHDSY DYDLQEQEND ILSWEKGAYK KWGRSKKKCS DLTLEEMKKQ AAVQCLRSAS
DESSGIETLV EELCCRLKDL QSEQEEKIHK KLEGSPSPEE ELSPTAKDQV EMYYEAFPPL
SEKPVCLQEI MTVWNKSKPC SYSSSSSSST VPPASTDTSS PKDCNSESEA VRERSSVASV
PMHEKAQSRS RHEKESKLSS STIEEKPAFY KRQIRHKPEG KTRPRSWSSG SSEAGSSSSG
NQGELKASMK YVKVRHKARE IRNRKGRNGQ NRHSLKHCGK AERGVHAGSG GSSSSSSNGS
IRQLCKRGKR PAKETGRSDS GNTAVKDLYV DSRNNKEYKE EPLWYTEPIA EYFVPLSRKS
KLETTYRNRE DTSTLTAEAV EDLSDSVRGL CISNSNIHRT YLAAGTFIDG HFVEMPAVIN
EDIDLAGTSL CSLPEDNKYL DDIHLSELTH FYEVDIDQSM LDPGASETMQ GESRILNMIR
QKSKENTDFE AECCIVLDGM ELQGERAIWT DSTSSVGAEG FFLQDLGNLA QFWECCSSSS
GDADGESFGG DSPVRLSPIL DSTMLSSHIL AGNQEPFSNI NEGSGINSCF SVFEVQCSNS
VLPFSFETLN LGSEHADSSA NMLGKTQSRL LIWTKNSAFE ENEHCSNLST RTCSPWSHSE
EARSDNETLN IQFEESTQFT AEDINYVVPR VSSDFVDEEL LDFLQDETCQ QNSRTLGEIP
TLVFKKRSKL ESVCGIQLEQ KAESKNFETT HACSESSPHG DGYSSGVIKD IWTKMVGRSS
VAAVETERTG EELFSTDVNN YCCCLDTEAK MEALQEPSRA VQRSEYHLWE GQKENMEKRA
FVSSELSKVD GGDYTTPSKP WDVAQDKENT FILGGVYGEL KTFNSDGEWA VVPPGHTKGS
LLQCAASDVV TIAGTDVFMT PGNSFAPGHR QLWKPFVSFE QSDMPKRGEN GVNKGFSFIF
HEDLLGACSN FQVEDPGLEY SLSSFDLSNP FSQVLHVECS FEPEGIASFS PSFKPKSILC
SDSDSEVFHP RICGVERTQY RAIRISPRTH FRPISASELS PGGGSESEFE SEKDEASVPI
PSHVDVFEDP QADLKPLEED AEKEGHYYGK LELESGKFLP RLKKSGMEKS AQTSLDSQEE
ATGILPKQNQ CLECNFNESL EINLESSAAN CKIMTQCEEE MSEFCSCKAG CQFPACEDNP
VSSGQLEEFP VLNTDVQEVT RNQEKQSWWE KALYSPLFPT SECEECYTNA KGENGIEECP
DAKETPSREE RLLDFNRVSS VYEARCTGER GSETKPNGLH RKMCSSASSD TGDTGSEAGG
EWVGPSREEL FSRTHL
