K0754_HUMAN
ID K0754_HUMAN Reviewed; 3515 AA.
AC O94854; E9PMC2; Q6ZSB2;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 5.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Microtubule-actin cross-linking factor 1, isoforms 6/7 {ECO:0000305};
DE AltName: Full=Uncharacterized protein KIAA0754;
GN Name=MACF1 {ECO:0000312|HGNC:HGNC:13664}; Synonyms=KIAA0754;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 72-1104.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-3515 (ISOFORM 7).
RC TISSUE=Brain;
RX PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XI. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:277-286(1998).
RN [4]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|PROSITE-
CC ProRule:PRU00792}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=6;
CC IsoId=O94854-3; Sequence=Displayed;
CC Name=7;
CC IsoId=O94854-4; Sequence=VSP_061506, VSP_061507;
CC Name=1; Synonyms=Macf1b;
CC IsoId=Q9UPN3-1; Sequence=External;
CC Name=2; Synonyms=Macf1a;
CC IsoId=Q9UPN3-2; Sequence=External;
CC Name=3;
CC IsoId=Q9UPN3-3; Sequence=External;
CC Name=5;
CC IsoId=Q9UPN3-4; Sequence=External;
CC Name=4;
CC IsoId=Q9UPN3-5; Sequence=External;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC87042.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC87042.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC87042.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AL137853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK127581; BAC87042.1; ALT_SEQ; mRNA.
DR EMBL; AB018297; BAA34474.2; -; mRNA.
DR RefSeq; NP_055853.1; NM_015038.1.
DR AlphaFoldDB; O94854; -.
DR BioGRID; 568672; 40.
DR IntAct; O94854; 8.
DR MINT; O94854; -.
DR iPTMnet; O94854; -.
DR PhosphoSitePlus; O94854; -.
DR BioMuta; HGNC:29111; -.
DR EPD; O94854; -.
DR jPOST; O94854; -.
DR MassIVE; O94854; -.
DR MaxQB; O94854; -.
DR PaxDb; O94854; -.
DR PeptideAtlas; O94854; -.
DR PRIDE; O94854; -.
DR ProteomicsDB; 22069; -.
DR GeneID; 643314; -.
DR GeneCards; KIAA0754; -.
DR HGNC; HGNC:13664; MACF1.
DR neXtProt; NX_O94854; -.
DR PharmGKB; PA128394598; -.
DR InParanoid; O94854; -.
DR OrthoDB; 118542at2759; -.
DR PhylomeDB; O94854; -.
DR PathwayCommons; O94854; -.
DR SignaLink; O94854; -.
DR BioGRID-ORCS; 643314; 10 hits in 252 CRISPR screens.
DR GenomeRNAi; 643314; -.
DR Pharos; O94854; Tdark.
DR PRO; PR:O94854; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; O94854; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 8.
DR Gene3D; 3.30.920.20; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; PTHR23169; 3.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00435; Spectrin; 12.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00150; SPEC; 16.
DR SUPFAM; SSF143575; SSF143575; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cytoplasm; Cytoskeleton; Metal-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..3515
FT /note="Microtubule-actin cross-linking factor 1, isoforms
FT 6/7"
FT /id="PRO_0000295722"
FT REPEAT 1012..1024
FT /note="1"
FT REPEAT 1026..1037
FT /note="2"
FT REPEAT 1038..1051
FT /note="3"
FT REPEAT 1052..1064
FT /note="4"
FT REPEAT 1065..1077
FT /note="5"
FT REPEAT 1078..1090
FT /note="6"
FT REPEAT 1091..1103
FT /note="7"
FT REPEAT 1104..1116
FT /note="8"
FT REPEAT 1117..1129
FT /note="9"
FT REPEAT 1130..1142
FT /note="10"
FT REPEAT 1143..1155
FT /note="11"
FT REPEAT 1156..1168
FT /note="12"
FT REPEAT 1169..1178
FT /note="13"
FT DOMAIN 3168..3203
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 3204..3239
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 3244..3316
FT /note="GAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00792"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..245
FT /note="13 X 13 AA approximate tandem repeat of P-T-S-P-A-A-
FT A-V-P-T-P-E-E"
FT REGION 965..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1710..1730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3078..3108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3332..3515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1150
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3351..3430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3462..3515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 3181
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3183
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3185
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3187
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3192
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3217
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3219
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3221
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3223
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 3228
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VAR_SEQ 1405..1427
FT /note="MFQKEQVDPLQMKLQQVNGLGQG -> VIVHFDSGKGLKSKVRFAGLTWW
FT (in isoform 7)"
FT /id="VSP_061506"
FT VAR_SEQ 1428..3515
FT /note="Missing (in isoform 7)"
FT /id="VSP_061507"
FT VARIANT 960
FT /note="I -> V (in dbSNP:rs1746842)"
FT /id="VAR_033338"
FT VARIANT 1105
FT /note="T -> A (in dbSNP:rs783822)"
FT /id="VAR_033339"
FT VARIANT 1194
FT /note="E -> K (in dbSNP:rs587523)"
FT /id="VAR_033340"
FT CONFLICT 231
FT /note="E -> K (in Ref. 2; BAC87042)"
FT /evidence="ECO:0000305"
FT CONFLICT 523
FT /note="L -> P (in Ref. 2; BAC87042)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3515 AA; 388666 MW; AAA86853C0C8741F CRC64;
MGKPLSRPDC LRRNPSCLGK GEEEDGYIED CYVPQRSIYD TMRINEQIDQ GSKLNQTSKS
TMEKMEGSTI SSNGTLGAAS NVFESRAPEG KKLDERIIFD ALKLSSDVQK SAPVPPRRRP
NAERKDNVNR RSWKSFMPPN FPEFAERIEA SLSEVSEAGA SNPSLQEKKE SSSALTESSG
HLDHREPQSE SVTLEHVSKS IGIPEVQDFK NLSGDCQDFR FQQHSANPPH EFQPVESEAV
ATSGNTDVMQ ESRFSSATWP RATKSLAKGG FSEKQHPLGD TACTVEMPPL SPCLSEELLD
PELHVLITPS LREKTESELK FEEDERWIMM EAEGEWEEEK LSDREKTFLM ADEKNSLADI
FEEREQANTA VVEDGSDCLA AVLRTFGHLS LGQICCPDDP QPAKDQLATV PKDIPLDCDC
VLTGEDILGE VANRTAQGLE GLVSDSACTV GTIDAEQLSD TDSVQMFLEL EKECLCEEGV
TPLVELQNQI SSEGLAASQD AENLLVISHF SGAALEKEQH LGLLHVRAKD YDTRLDCGYF
NTLDSSQVPN AVELIAHVDI MRDTSTVSKE ECEKVPFSPR TAEFKSRQPA DLDSLEKLDP
GGLLNSDHRV SHEEKLSGFI ASELAKDNGS LSQGDCSQTE GNGEECIERV TFSFAFNHEL
TDVTSGPEVE VLYESNLLTD EIHLESGNVT VNQENNSLTS MGNVVTCELS VEKVCDEDGE
AKELDYQATL LEDQAPAHFH RNFPEQVFQD LQRKSPESEI LSLHLLVEEL RLNPDGVETV
NDTKPELNVA SSEGGEMERR DSDSFLNIFP EKQVTKAGNT EPVLEEWIPV LQRPSRTAAV
PTVKDALDAA LPSPEEGTSI AAVPAPEGTA VVAALVPFPH EDILVASIVS LEEEDVTAAA
VSAPERATVP AVTVSVPEGT AAVAAVSSPE ETAPAVAAAI TQEGMSAVAG FSPEWAALAI
TVPITEEDGT PEGPVTPATT VHAPEEPDTA AVRVSTPEEP ASPAAAVPTP EEPTSPAAAV
PTPEEPTSPA AAVPPPEEPT SPAAAVPTPE EPTSPAAAVP TPEEPTSPAA AVPTPEEPTS
PAAAVPTPEE PTSPAAAVPT PEEPTSPAAA VPTPEEPASP AAAVPTPEEP ASPAAAVPTP
EEPAFPAPAV PTPEESASAA VAVPTPEESA SPAAAVPTPA ESASFAAVVA TLEEPTSPAA
SVPTPAAMVA TLEEFTSPAA SVPTSEEPAS LAAAVSNPEE PTSPAAAVPT LEEPTSSAAA
VLTPEELSSP AASVPTPEEP ASPAAAVSNL EEPASPAAAV PTPEVAAIPA ASVPTPEVPA
IPAAAVPPME EVSPIGVPFL GVSAHTDSVP ISEEGTPVLE EASSTGMWIK EDLDSLVFGI
KEVTSTVLHG KVPLAATAGL NSDEMFQKEQ VDPLQMKLQQ VNGLGQGLIQ SAGKDCDVQG
LEHDMEEINA RWNTLNKKVA QRIAQLQEAL LHCGKFQDAL EPLLSWLADT EELIANQKPP
SAEYKVVKAQ IQEQKLLQRL LDDRKATVDM LQAEGGRIAQ SAELADREKI TGQLESLESR
WTELLSKAAA RQKQLEDILV LAKQFHETAE PISDFLSVTE KKLANSEPVG TQTAKIQQQI
IRHKALNEEI VNRKKNVDQA IKNGQALLKQ TTGEEVLLIQ EKLDGIKTRY ADITVTSSKA
LRTLEQARQL ATKFQSTYEE LTGWLREVEE ELATSGGQSP TGEQIPQFQQ RQKELKKEVM
EHRLVLDTVN EVSRALLELV PWRAREGLDK LVSDANEQYK LVSDTIGQRV DEIDAAIQRS
QQYEQAADAE LAWVAETKRK LMALGPIRLE QDQTTAQLQV QKAFSIDIIR HKDSMDELFS
HRSEIFGTCG EEQKTVLQEK TESLIQQYEA ISLLNSERYA RLERAQVLVN QFWETYEELS
PWIEETRALI AQLPSPAIDH EQLRQQQEEM RQLRESIAEH KPHIDKLLKI GPQLKELNPE
EGEMVEEKYQ KAENMYAQIK EEVRQRALAL DEAVSQSTQI TEFHDKIEPM LETLENLSSR
LRMPPLIPAE VDKIRECISD NKSATVELEK LQPSFEALKR RGEELIGRSQ GADKDLAAKE
IQDKLDQMVF FWEDIKARAE EREIKFLDVL ELAEKFWYDM AALLTTIKDT QDIVHDLESP
GIDPSIIKQQ VEAAETIKEE TDGLHEELEF IRILGADLIF ACGETEKPEV RKSIDEMNNA
WENLNKTWKE RLEKLEDAMQ AAVQYQDTLQ AMFDWLDNTV IKLCTMPPVG TDLNTVKDQL
NEMKEFKVEV YQQQIEMEKL NHQGELMLKK ATDETDRDII REPLTELKHL WENLGEKIAH
RQHKLEGALL ALGQFQHALE ELMSWLTHTE ELLDAQRPIS GDPKVIEVEL AKHHVLKNDV
LAHQATVETV NKAGNELLES SAGDDASSLR SRLEAMNQCW ESVLQKTEER EQQLQSTLQQ
AQGFHSEIED FLLELTRMES QLSASKPTGG LPETAREQLD THMELYSQLK AKEETYNQLL
DKGRLMLLSR DDSGSGSKTE QSVALLEQKW HVVSSKMEER KSKLEEALNL ATEFQNSLQE
FINWLTLAEQ SLNIASPPSL ILNTVLSQIE EHKVFANEVN AHRDQIIELD QTGNQLKFLS
QKQDVVLIKN LLVSVQSRWE KVVQRSIERG RSLDDARKRA KQFHEAWKKL IDWLEDAESH
LDSELEISND PDKIKLQLSK HKEFQKTLGG KQPVYDTTIR TGRALKEKTL LPEDSQKLDN
FLGEVRDKWD TVCGKSVERQ HKLEEALLFS GQFMDALQAL VDWLYKVEPQ LAEDQPVHGD
LDLVMNLMDA HKVFQKELGK RTGTVQVLKR SGRELIENSR DDTTWVKGQL QELSTRWDTV
CKLSVSKQSR LEQALKQAEV FRDTVHMLLE WLSEAEQTLR FRGALPDDTE ALQSLIDTHK
EFMKKVEEKR VDVNSAVAMG EVILAVCHPD CITTIKHWIT IIRARFEEVL TWAKQHQQRL
ETALSELVAN AELLEELLAW IQWAETTLIQ RDQEPIPQNI DRVKALIAEH QTFMEEMTRK
QPDVDRVTKT YKRKNIEPTH APFIEKSRSG GRKSLSQPTP PPMPILSQSE AKNPRINQLS
ARWQQVWLLA LERQRKLNDA LDRLEELKEF ANFDFDVWRK KYMRWMNHKK SRVMDFFRRI
DKDQDGKITR QEFIDGILAS KFPTTKLEMT AVADIFDRDG DGYIDYYEFV AALHPNKDAY
RPTTDADKIE DEVTRQVAQC KCAKRFQVEQ IGENKYRFGD SQQLRLVRIL RSTVMVRVGG
GWMALDEFLV KNDPCRARGR TNIELREKFI LPEGASQGMT PFRSRGRRSK PSSRAASPTR
SSSSASQSNH SCTSMPSSPA TPASGTKVIP SSGSKLKRPT PTFHSSRTSL AGDTSNSSSP
ASTGAKTNRA DPKKSASRPG SRAGSRAGSR ASSRRGSDAS DFDLLETQSA CSDTSESSAA
GGQGNSRRGL NKPSKIPTMS KKTTTASPRT PGPKR
